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The seizure sensitive rats were made by subcutaneous injection of a convulsant dose (10mg/kg) of KA. Normal saline , PL017 or β-FNA were infused constantly into ventral hippocampus of awakened and freely moving animals for 7 days by mini-osmotic pumps. 7 days later, all rats were given subcutaneously with subconvulsant dose of KA.

皮下注射惊厥剂量(10mg/kg)的KA制备颞叶癫癎模型的癫癎发作敏感大鼠,采用微渗透泵技术分别将生理盐水、PL017和β-FNA连续7天恒速注入清醒自由活动的上述动物的腹侧海马内。7天后皮下注射阈下剂量(5mg/kg)KA检测癫癎发作敏感性形成情况。

Changes in false operation group, rehabilitation group and the intracerebral synaptic structure parameter of the model group.

为此本实验采用右侧大脑中动脉缺血大鼠模型应用滚笼网状训练、平衡训练以及Morris水密宫训练后,观察假手术组、经康复训练的康复组和未经训练的模型组大鼠在Y-迷宫分辨学习能力和一次性被动回避反应记忆保持能力的行为模式以及海马CA3区突触结构参数测定、在体LTP记录和NMDA受体通道电流记录等方法研究康复训练对梗死大鼠学习记忆的影响及其机制。研究内容包括: 1。

But whether the compound composed of them has suppressive effect on absence - like seizures of genetic tremor rats hasnt been reported. Furthermore, the animal models of investigating antiepileptic drugs were mostly induced by chemoconvulant or electrical stimulation. Since genetic factor is more primary in clinical epileptic patients, we used tremor rats fetched in from Japan as experimental animal models. We implanted electrodes in cortical and hippocampus of tremor rats and then recorded the electroencephalograms to observe effects of the traditional Chinese medicinal compound composed of Scolopendra, Bombyx Batryticatus, Uncaria and Arisacma Consanguineum on absence - like seizures in tremor rats.

而且以往多以化学致痫剂或电刺激等方法造模进行抗癫痫药物的研究,但在临床的癫痫患者中遗传因素占有相当大的比例,所以本实验应用了从日本引进的具有遗传性癫痫小发作的震颤大鼠作为实验动物模型,通过在震颤大鼠脑皮质和海马慢性安插电极后进行脑电图的记录,观察以蜈蚣、僵蚕、钩藤、制南星四味药为主的复方中药制剂对震颤大鼠癫痫小发作的抑制作用。

Results A dense accumulation of fos and jun positive neurons exhibited in the FC, temporal cortex, CA1, DG, PVN, the supraoptic nucleus and the dorsomedial nucleus.

结果 两种方式应激结束后3h,脑皮层的额叶和颞叶、海马的CA1和DG及下丘脑的PVN、视上核、背内侧核均有较强的c-fos和 c-jun表达。

The distributions of Hup A into rat brain tissues following intranasal dosing were compared with those after intravenous and intragastric dosing by tissue homogeneization.

结果大鼠鼻腔给药血浆AUC0→6h为静注的0.94倍,但脑脊液AUC0→6h为静注和灌胃的1.3和2.3倍;大鼠鼻腔给药后大脑、海马、小脑、左右嗅球的AUC0→6h分别为静注的1.5,1.3,1.0,1.2和1.0倍,为灌胃的2.7,2.2,1.9,3.1和2.6倍。

It may means that Iridoids composition of Valeriana jatamansi Jones doesn\'t regulate the TPH1 transcription expression.3.4 Effection of Iridoids composition of Valeriana jatamansi Jones on SP and VIP of IBS rats induced by chronic stressMethods:Animals were randomly divided into7 groups:normal group,model group, OSD group,FXT group and Iridoids composition of Valeriana jatamansi Jones groups in quantiy of 24.92mg/kg,12.46mg/kg,6.23mg/kg.

造模后,中枢5-HT呈现降低趋势,这可能是导致动物出现活动能力下降和兴趣缺失的原因之一,蜘蛛香环烯醚萜可以增加下丘脑、海马和杏仁核中5-HT含量,推断蜘蛛香环烯醚萜可通过干预中枢的5-HT通路来改善IBS精神症状。3.2蜘蛛香环烯醚萜对胃肠激素的影响目的:探讨蜘蛛香环烯醚萜对慢性应激所致IBS大鼠SP和VIP的影响方法:动物随机分为对照组、模型组、昂丹司琼组、氟西汀组、蜘蛛香环烯醚萜24.92mg/kg、12.46mg/kg、6.23mg/kg组。

Previous studies show different interneuron changes in different models of epilepsy, which are focused on the onset of epilepsy, but not the onset of the spontaneous recurrent seizures.

在不同癫痫模型和患者海马观察含PV、CR、CB中间神经元数量变化的报道已有较多,但既往的研究着重于颞叶癫痫的始发过程上,而对颞叶癫痫发生后向自发性复发性发作演变过程中这三种中间神经元变化的研究较少。

Brain temperature in the unregulated group dropped to 34.0 +/- 0.4 degrees C at 1 h. The hypothermic group had improed motor function assessed using beam balance and inclined plane tests s.

未调温度组的脑温1小时后降低到34.0 +/- 0.4°,用游梁平衡和倾泻平面测试(beam balance and inclined plane tests)评估,低温组的运动功能比正常温度组有改善, 5周时 CA1海马神经元存活数目增加与低温的程度相关。

Methods At different timepoints after microwave exposure of 65mW/cm^2 for 20mm, learning and memory ability was evaluated with shuttle box test and Morris' water maze test, long-term potentiation was detected in hippocampal slices in rats.

采用功率密度为65mW/平方公分的微波全身一次辐照大鼠20min,在辐照后不同时相点观察大鼠学习记忆行为的改变(穿梭箱试验和Morris水迷宫试验)和海马离体脑片LTP的诱导变化。

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