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Comparison results revealed that there was significantly reduced functional connectivity in the left posterior cingulate cortex, vbilateral anterior cingulate cortex, bilateral medial prefrontal cortex, left parahippocampal cortex in MHE patients, while functional connectivity increased in the right precuneus.

但与正常对照组相比,MHE患者大部分脑缺省模式网络脑区功能连接降低,包括:左侧后扣带回、双侧前扣带回、双侧额中回、左侧海马旁回;而右侧楔前叶的功能连接较正常对照组升高。

Neuronalα4β2 nicotinic acetylcholine receptors are the most widespread subtypes in central nervous system.α4β2 nAChRs mainly exist in procerebrum, parietal lobe cortex, temporal lobe cortex, hippocampus, basal ganglion and cerebellum.

神经元烟碱受体α4β2亚型是中枢神经系统分布最为广泛的烟碱受体亚型,占脑内与烟碱有高亲和力的nAChRs的90%,主要分布在前脑、顶叶和颞叶皮质、海马、基底神经节和小脑。

There are only 17 Propithecus coronatus living in captivity worldwide.

只有17个冕冠海马全世界圈养生活。

OBJECTIVE: To observe Bcl-2 and Bax expressions in hippocampus after ischemia on cerebral ischemic mouse model for the investigation of this animal model on proteinic molecular expression level, which would provide a laboratorial gist for future application of this animal model in cerebral ischemia researches.

目的:在小鼠全脑缺血模型上观察缺血后海马区Bcl-2和Bax的表达,在蛋白分子表达水平对该模型进行研究,为这种模型在今后脑缺血研究中的应用提供实验依据。

Aim: To explore the effect of pueraria crude extract and standard of pure puerafin on hippocampus cells from fetal mice.

目的:观察葛根粗提物和葛根素标准品对胎鼠海马神经元活力的影响。

PKCγ participates the process of hyperalgesia,pain transduction,changes of LTP in the hippocampus,spatial learning memory,and movement coordination of Purkinje cells.

PKCγ参与疼痛过敏和转导、海马区长时易化的改变、空间记忆学习和浦肯野细胞运动协调等。

The model of brain concussion of rat can be established successfully using iron pendulum hitting device; 2. The spatial learning and memory deficits of the rats are detected by MWM in early period post-BC(from 1 to 3 days after BC); 3. Pycnosis degeneration or necrosis neurons of the cerebral cortex, dorsal hippocampus, dentate fornix and brainstem reticular formation are identified in BC rats; 4. There are significantly changes in the number and activity of cholinergic neurons in the basal forebrain and brainstem reticular formation after BC; 5. The change of cerebral neurons and cholinergic neurons correlate with cognitive deficits in BC rats .

1、单摆式闭合性机械打击装置能成功建立脑震荡大鼠模型;2、脑震荡大鼠在MWM实验中出现早期空间认知行为障碍;3、脑震荡大鼠大脑皮质、背侧海马、齿状回和脑干网状结构出现程度不等的部分神经元固缩变性和不完全性坏死;4、脑震荡大鼠基底前脑、脑干网状结构ChAT活性表达有明显变化;5、脑震荡大鼠认知障碍与相关脑区神经元、胆碱能神经元的变化有关联。

There were no statistically differences between the 8th~ 14thday, the 15th - 21th day post-BC and the control group. During the rt~24tkday post-BC , pycnosis degeneration or necrosis neurons of the locus cerebral cortex, dorsal hippocampus, dentate fornix were significantly increased, then decreased gradually, but recovered to normal by the 24thday after BC, and especially in parietal cortex and piriform cortex the necrosis neurons were significantly increased than temporal cortex , and there were no statistically difference berween the left and the right side. Pycnosis degeneration or necrosis neurons in the brainstem reticular formation were markedly increased in the 4thday after BC, and there were no statistically difference among the other groups and the control group.

与对照组相比,BC后在大脑皮质、背侧海马和齿状回部位,固缩变性和不完全坏死细胞数先显著增加(P<0.05),然后逐渐减少,至24d基本恢复正常;顶叶、梨状皮质比颞叶皮质变性坏死细胞多,差异有高度显著性(P<0.01);大脑左侧比右侧变性坏死细胞稍少但差异无显著性;在BC后4d,脑桥核、斜方体核平面的脑干网状结构中固缩变性和不完全坏死细胞数明显增多(P<0.05),其它组间无显著性差异。

RESULTS: The layer of CA1 pyramidal cells in both AO groups became thinner with pyknotic nuclei than control.

结果:与对照组相比,各氯化铝组均可见海马CA1区细胞层变薄伴明显核固缩。

Results In comparison with the controls, the nuclei of many neurons were pyknotic or disappeared, the Nissl substance also showed various degrees of abnormality, and the dendrites were stretched in the high-fluoride and low-iodine groups, and in the high-fluoride plus low-iodine group, espacially in the early developmental stage.

结果 与对照组相比,高氟组和低碘组大鼠大脑皮质及海马内有较多神经元核固缩、核溶解及细胞轮廓不清晰。

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