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These changes of pathology are consistence with that of epileptiform rat induced by Munc18 antibody.

上述病理学的变化与Munc18抗体致痫大鼠海马区所观察到的病理改变相同。

The surgical methods included standard anterior temporal lobectomy, selective amygdalohippocampectomy and epileptogenic focus resection. And the pathologic examination was done postoperatively.

手术方式包括标准颞前叶切除术、选择性海马杏仁核切除术及致痫灶切除术等,对切除的脑组织进行病理学检查。

Objective To examine the value of Edaravone in the treatment of vascular dementia through ethologic and pathologic changes induced by chronic cerebral ischemiaMethods Wistar rats were randomly divided into sham operated group,model group,edaravone group and duxil groupThe chronic cerebral hypoperfusion models were made by permanent bilateral occlusion of both common carotid arteriesThe memory ability and ultramicrostructure of brain tissue were observedResults The escape latencies in model group were more significantly prolonged than that in the other groups (P<005)But there was no significant difference between edaravone and duxil groupAnd pathologic changes observed by electron microscope in nerve cell of edaravone group and duxil group and model group were fairly light than that in sham operated groupEdaravone group had increased mitochondrium and frontal membranous synaptic vesicle and more productive metabolic activityConclusions Edaravone can lessen injures of hippocampal neurons loss to improve the spatial learning and memory abilitiesAnd it is proved further that edaravone can treat VD

目的 观察依达拉奉对慢性缺血致血管性痴呆大鼠行为学及形态学的影响,探讨依达拉奉在治疗VD中的应用价值。方法实验分假手术组、模型组及都可喜对照组及依达拉奉治疗组,应用双侧颈总动脉结扎方法制备慢性脑缺血大鼠痴呆模型,观察各组大鼠的记忆功能及脑组织超微结构改变。结果缺血组水迷宫表现同对照组、都可喜组及依达拉奉组相比有显著差异(P<005),依达拉奉组与都可喜组相比未见显著差异。同时电镜观察结果也发现依达拉奉组及都可喜组与模型组及假手术组相比神经细胞病理改变较轻,且依达拉奉组线粒体及前膜突触小泡增多,代谢活动较都可喜组旺盛。结论依达拉奉可能通过减轻海马神经元的损伤来改善慢性脑缺血大鼠空间学习记忆障碍,证明依达拉奉对慢性缺血致VD大鼠具有治疗作用。

Excitatory and inhibitory pathways in the hippocampus continue to develop after birth.

海马的兴奋性和抑制性通路在出生后继续发育。

BP can damage rats' spatial learning and memory, and which could be related to decreased contents of excitatory amino acids in hippocampus.

BP能使大鼠空间学习记忆能力降低,这可能与海马兴奋性氨基酸含量的降低有关。

The hippocampus plays a critical role during the consolidation of trace eyeblink conditioned responses. However, the role of its related structure such as dentate gyms remains unclear.

海马在追踪性眨眼条件反应的巩固过程中发挥重要作用,但解剖学上与其紧密联系的齿状回在此过程中的作用尚不清楚。

The present study was aimed at monitoring the activity of single granule cell in the DG during the consolidation of trace eyeblink CRs, and elucidating the possible role of DG during this hippocampus-dependent task.

实验拟观察齿状回颗粒细胞在追踪性眨眼条件反应巩固过程中的放电活动,阐明齿状回在此海马依赖任务中所发挥的作用。

Objective To study the influence of formaldehyde sulphoxylate on the expression of glial fibrillar acidic protein in mice hippocampus.

目的研究次硫酸氢钠甲醛对小鼠海马神经胶质酸性蛋白表达的影响。

Objective To study the influences of Acrylamide on the expression of Glial Fibrillar Acidic Protein in murine Hippocampus.

目的 研究丙烯酰胺对小鼠海马神经胶质酸性蛋白表达的影响。

Objective To study the influence of formaldehyde sulphoxylate on the expression of glial fibrillar acidic protein in mice hippocampus.

目的 研究次硫酸氢钠甲醛对小鼠海马神经胶质酸性蛋白表达的影响。

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