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Third, we found that DNMT inhibition causes bdnf DNA demethylation and that demethylation is sufficient to lead to increased bdnf mRNA levels in hippocampus in vivo.

第三,我们发现DNMT抑制剂会造成bdnf DNA的去甲基化。这种去甲基化足以引起体内bdnf 信使RNA水平在海马体内的提高。

Centrophenoxine combined with point thread embedding protects the nerve cells in the dentale gyrus area of the hippocampus better and improves the learning and memory of the VD model rats more effectively.

在2006年3~8月采用药物和埋线结合的方法,用盐酸甲氯芬酯联合穴位埋线治疗VD大鼠,观察该方法对VD大鼠海马神经细胞及学习记忆的影响,以期为中西医结合治疗VD提供实验依据。

centrophenoxine combined with point thread embedding protects the nerve cells in the dentale gyrus area of the hippocampus better and improves the learning and memory of the vd model rats more effectively.

盐酸甲氯芬酯联合穴位埋线能保护vd大鼠海马神经细胞,明显提高其学习记忆能力。

Among various regions of the hippocampal cortex and gyrus dentata,microvessel density in sector CA2 was the highest...

海马皮质各区和齿状回的微血管密度,以CA_2区最高,CA_3和CA_1区居中,CA_4区次之,齿状回最低。

In the hippocampal formation there were many terminals containing AchE and they distribute mainly in the deep part of stratum oriens and both sides of granular layer in the area dentata.

AchE组化染色显示海马和齿状回内有大量AchE阳性终末,主要位于多形细胞层的深部和齿状回颗粒细胞层两侧。

Consequence:Afer duplicating the model,many patho-representations occur in theaging rats including the worse general states,increasing active oxygen freeradical,lipid peroxidation and apoptosis,reducing antioxygen capability andionic transport capability in the cell envelope,overexpression of P16,impairing hippocamp nerve cell architecture and depositive lipofuscin inultramicro-morphology.

结果:D-半乳糖致亚急性衰老大鼠出现一般状态较差、活性氧自由基和脂质过氧化产物增加、抗氧化能力明显下降、细胞膜离子转运能力降低、P16过度表达、细胞凋亡增加、海马神经元细胞超微结构损伤以及神经元细胞内脂褐素沉积的病理表现。

Lead ; Aluminum ; Synaptic plasticity ; Long-term potentiation ; Depotentiation ; Hippocampus ; Rats

铅; 铝;突触可塑性;长时程增强;去长时程增强;海马;大鼠

The patients were not mediated with neuroleptics,too. The results show the decrease of NAA in dorsolateral prefrontal cortex and hippocampus which mean neurons deficit and dysfunction at the time of onset.

研究结果表明精神分裂症在发病时前额叶背外侧回和海马就已经存在NAA的降低,即精神分裂症在发病时就已经存在神经元的缺失和/或神经元功能、活力的低下。

Results A dense accumulation of fos and jun positive neurons exhibited in the FC, temporal cortex, CA1, DG, PVN, the supraoptic nucleus and the dorsomedial nucleus.

结果 两种方式应激结束后3h,脑皮层的额叶和颞叶、海马的CA1和DG及下丘脑的PVN、视上核、背内侧核均有较强的c-fos和 c-jun表达。

Objective To explore into the probable mechanism of Alzheimer's diseaseby the acupuncture treatment combined with DGSYS of TCM.Methods Three kinds of model rats with dysmnesia which were made by injected into drug of scopolamine or NaNo 2 in the abdomen separately and injured at the hippocampal CA 1 in brian by drug of quinolinic acid treated by single acupuncture or acupuncture combined with DGSYS of TCM or DGSYS of TCM were observed separately,to compare different influence on dysfunctions of acuquisition and consoli-dation of memory induced by drugs and injure with nimodipineor the normal rats.

通过腹腔注射药物东莨菪碱或亚硝酸钠,或者用奎宁酸损毁大脑海马CA 1 区诱发大鼠发生记忆力障碍,造成不同类型的大鼠&痴呆&模型,对照性观察针刺、针刺加DGSYS、DGSYS及NM对记忆障碍功能的影响和与记忆相关实验指标参数的变化。

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