海马

Objective By using Alzheimer's model rats induced by AlCl3,the effects and mechanism of Ginkgo flavone were investigated.Methods Ginkgo flavone were given to rats by oral for seven weeks.Then,the ability of study of mice were determined by step-down test and the number of neurons in the Bregma hippocampus containing β-APP proteins were counted.

目的 研究银杏黄酮对三氯化铝所致痴呆模型鼠学习记忆能力和海马内β-APP阳性神经元的影响，以期探讨银杏黄酮抗老年性痴呆的作用机制方法用三氯化铝致老年性痴呆模型大鼠实验对象，以其学习记忆能力、背海马和齿状回内β-APP阳性神经元的量为指标，全面考察银杏黄酮抗老年性痴呆的作用。

objective by using alzheimer's model rats induced by alcl3,the effects and mechanism of ginkgo flavone were investigated.methods ginkgo flavone were given to rats by oral for seven weeks.then,the ability of study of mice were determined by step-down test and the number of neurons in the bregma hippocampus containing β-app proteins were counted.results to the model rats,ginkgo flavone 100,200,400mg?

目的 研究银杏黄酮对三氯化铝所致痴呆模型大鼠学习记忆能力和海马内β-app阳性神经元的影响，以期探讨银杏黄酮抗老年性痴呆的作用机制。方法用三氯化铝致老年性痴呆模型大鼠为实验对象，以其学习记忆能力、背海马和齿状回内β-app阳性神经元的数量为指标，全面考察银杏黄酮抗老年性痴呆的作用。

After placement in a stereotaxic apparatus, A microdialysis probe was implanted in the left hippocampal CA1 region (2 mm to the left and 3.6 mm posterior to the bregma and 2 mm below the cortical surface).

切开头皮，用微型颅钻分别在左右海马CA1区(前囟3.6mm和中线左、右旁开3mm)打开一直径约2mm的圆孔，将微透析探针刺入左侧海马CA1区2mm，用乳酸钠林格氏液以2.5μl/min的速度持续灌注，稳定60min待脑电图波形稳定后收集脑组织透析液，间隔时间为10min，直至再灌注后2h。

Methods: We extract hippocampus chondriosome from the vascular dementia rat and measure the activity of mitochondrial COX by the UV-spectrophotometer, then detect its gene order through RT-PCR.

从VD大鼠中提取海马线粒体利用紫外分光光度计技术检测各组大鼠海马COX活性，通过RT-PCR等技术对其基因序列进行检测。

Glycine receptor competitive antagonist partially reversed the effects of propofol. When slices were preincubated with GABA〓 receptor and glycine receptor competitive antagonists collaterally or preincubated with GABA〓 receptor incompetitive antagonist and glycine receptor competitive antagonist collaterally, 100μM propofol still decreased the amplitude of EPSCs.

2在膜钳制电压为-70mV条件下，100M丙泊酚明显降低合用GABA〓受体和甘氨酸受体竞争性拮抗剂预孵的大鼠海马脑片CA1区电刺激诱发的EPSC幅值，下降程度小于单纯甘氨酸受体竞争性拮抗剂预孵组，大于单纯GABA〓受体竞争性拮抗剂预孵组；而且，100M丙泊酚更是明显降低合用GABA〓受体非竞争性拮抗剂和甘氨酸受体竞争性拮抗剂预孵的大鼠海马脑片CA1区电刺激诱发的EPSC幅值，下降程度甚至大于单纯甘氨酸受体竞争性拮抗剂预孵组。

Results The results showed that:(1) Only fluoxetine could decrease the 5-HT immunoreaction in cornu ammonis and thalamas in rat brain in the acute group;(2) Four antidepressant drugs could decrease 5-HT immunoreaction in six regions of rats brain in the chronic group.

结果 ①一次给药后，仅氟西汀降低大鼠海马和丘脑5-HT免疫反应性；②长期给药组中，4种抗抑郁药均能降低大鼠额叶、海马、丘脑、脑干和小脑的5-HT免疫反应性。

A small portion of BrdU and NeuN double labeled cells could be detected in the cortex at the early stage of development, and in the striatum and CA of the hippocampus in all groups. The majority of BrdU labeled cells were neuroglia, and the number of neuroglia cells decreased dramatically with brain maturation. Neurogenesis is the major cytogenesis in the dentate gyrus.

皮层在发育早期以及纹状体和海马CA区在发育各期检测到极少数为新生神经元细胞，多数分化为胶质细胞；海马齿状回以神经元细胞再生为主；胶质细胞的再生随脑组织发育的成熟而逐渐减少。

Methods: We divide the rats into 5 groups in random, with Morris method, detect the change of some active oxygen radicals such as super-oxide demitasse, Nitric Oxide Synthase, malondialdehyde etc. Also, we detect the change of cholinesterase, Monoamine Oxidize; using HE,PAS staining, immuno-histochemical technique, detect hippocampus CA1 cerebral pathology slices optical density value of NOS, CHE and lipofuscin of neural cell; detecting apoptosis rate and the expression of P53 , which are neuronal apoptosis related genes.

大鼠随机分为5组，采用"Morris水迷宫"法观察脑缺血性模型大鼠学习记忆功能，检测超氧化物歧化酶、一氧化氮合酶、丙二醛等自由基代谢异常的改变，检测胆碱酯酶、单胺氧化酶等老化相关酶的变化、脑组织神经细胞免疫组织化学技术、检查海马CA1区脑组织的病理切片，检测NOS、CHE光密度值；流式细胞技术：检测细胞凋亡率，及促细胞凋亡基因、P_(53)蛋白表达；病理切片采用HE染色、PAS染色及免疫组化法检查，检测对大鼠海马神经元细胞一般病理变化及脑细胞内脂褐含量。

Hippocampus CA1 area is the location studying .In hippocampus CA1 area cone cell tier, CA2 shapes with CA3 area also have large amount of NPY to be able to there exist in nerve basic in the tier, but the person remembers that the obstacle relation sees news report not yet with studying difficult to bring nature falling sickness concurrency under control.

海马CA1区是学习记忆的关键部位；在海马CA1区的锥体细胞层，CA2与CA3区的多形层中也有大量的NPY能神经元存在，但其与难治性癫痫并发的学习记忆障碍的关系尚未见报导。

Objective To observe the expression of nicotinic acetylcholine receptor in the brain's fimbria/fornix transected rats, the effect of ectogenic estrogen on it, and its relation with Alzhelmer's disease.

目的 以双侧穹隆海马伞切断制作阿尔茨海默病大鼠模型，观察脑内海马CA1区和皮层区烟碱型乙酰胆碱受体表达的变化，探讨与 AD相关的发病机制，并观察雌激素的干预作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。