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Results:InsR、IRS-1 and IRS-2 are widely distributed in the brain of normal adult rat ,especially in the cerebral cortex 、hippocampus and numerous hypothalamic nuclei including the arcuate nucleus、ventromedial nucleus and paraventricular nucleus which are crucial for the control of food intake.

结果:InsR、IRS-1、IRS-2在正常成年大鼠脑中广泛分布,在与学习记忆和能量代谢相关的脑区如大脑皮质、海马、丘脑和下丘脑的部分核团均有表达。

Which may be useful in the study of insulin signaling transduction pathway in the brain.methods:use immunohistochemical techniques to investigate the neuronal distribution of insr、irs-1 and irs-2 proteins in rat brain with polyclonal insr、irs-1 and irs-2 antiserum.results:insr、irs-1 and irs-2 are widely distributed in the brain of normal adult rat ,especially in the cerebral cortex 、hippocampus and numerous hypothalamic nuclei including the arcuate nucleus、ventromedial nucleus and paraventricular nucleus which are crucial for the control of food intake.conclusion:insr、irs-1 and irs-2 are widely distributed in the brain of normal adult rat, suggesting that they may play an important role in the normal function of central nervous system.

应用免疫组织化学染色的方法观察正常成年大鼠脑中insr、irs-1、irs-2的分布。结果:insr、irs-1、irs-2在正常成年大鼠脑中广泛分布,在与学习记忆和能量代谢相关的脑区如大脑皮质、海马、丘脑和下丘脑的部分核团均有表达。结论:insr及irs-1、irs-2在正常成年大鼠脑中广泛表达,但表达部位不完全一致,提示它们在大鼠中枢神经系统的正常功能活动中可能发挥不同的作用。

Intensely and densely stained PKC_γimmunoreactive neurons were mainly observed in the cerebral cortex, hippocampus,amygdaloid complex,cerebellar cortex,ventral and dorsal cochlear nuclei,caudal spinal trigeminal nucleus and spinal dorsal horns.

研究发现PKCγ阳性神经元广泛分布于大鼠神经系统,密集、浓染的PKCγ阳性神经元主要见于大脑皮质、海马、杏仁复合体、小脑皮质、耳蜗腹侧核和耳蜗背侧核。

The presence of phosphorylated ERK1/2 in nucleus, cytoplasm, neurites suggests a role for ERK1/2 in phosphorylation and regulation of both cytoplasmic and nucleus targets. Numerous neurons were immunostained for ERK1/2 in Purkinje's layer, lateral reticular nucleus, some nuclei of reticular formation, raphe nuclei, nuclei related with visceral sensation, some nuclei in hypothalamus and preoptic area, amygdala, hippocampal formation, part of isocortex.

磷酸化ERK1/2在浦氏细胞层(Purkinje'slayer),外侧网状核,网状结构部分核团,中缝核群,内脏感觉有关核团,下丘脑和视前区部分核团,杏仁核,海马结构和部分同型皮质中标记数目较大的神经元。

You can see obliteration of the temporal horn of the lateral ventricle because of swelling of the hippocampus.

由于海马区的肿胀,可以看到侧脑室的下角消失。

No effect of temperature was observed in 1 and 2 week-old rats.

温度对1周和2周龄乳鼠的海马脑片tau蛋白的表达无影响。

Results The number and optical density of Bax in hippocampus of PTZ group rats was higher than that of control group rats.

然后处死大鼠取脑,免疫组织化学的方法检测海马神经元Bax和Bcl-2蛋白的表达。

Results Morphological and organelle c CA2 and CA3 districts in the sub acute group rats.

结果 NCAM在不同海拔大鼠海马CA2区和CA3区神经细胞的胞膜上的量随海拔的升高而降低。

Methods: To establish the rat model of spleen-deficiency by the methods of purgation with bitter and cold nature dyugs, omproper diet and overstrain. Immunohistochemistr and in situ hybridization were used to tetect and C-fos and C-JUNmRNA expression in the hypothalamus ventral kernel, the hippocampi CA1 area and forehead cortex.

采用苦降泻下、饮食失节加劳倦过度法建立脾虚大鼠模型,免疫组化法、原位杂交法检测下丘脑腹侧核、海马CA1区、前额叶皮层C-fos水平与C-JUNmRNA表达变化及归脾汤的治疗作用。

Results Immunohistochemistry revealed plaques in pallium, cerebellum and hippocampus.

结果 免疫组化显示在大脑皮层、小脑及海马的神经细胞有Aβ沉淀形成。

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