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Results:The three groups of P77PMC rats which experienced 30 and less than 30 times of audiogenic seizure and the Wistar control group did not display MF sprouting in dentate gyrus, however, the group of P77PMC rats which experienced 50 times of AGS was found hippocampal MF sprouting into the inner molecular layer of dentate gyrus.

结果:在全身性强直阵挛性惊厥发作次数少于30次的P77PMC大鼠以及对照的Wistar大鼠海马内均未见到MF发芽表现;而在经历50次Ⅳ~Ⅴ级听源性惊厥发作的一组P77PMC大鼠海马内观察到了MF发芽的现象,在海马齿状回内分子层内见到Timm染色呈棕黑色颗粒异常分布的MF末梢。

The localization of the S-labelled AVP4-8 binding sites in the rat hippocampus was studied by using autoradiographic approach via observing the selective damages of hi_p-pocampal neurons by neurotoxins,and the developmental regulation of the hippocampalAVP4-8 receptor by pretreatment with exogenous AVP4-8 was observed.

本文利用放射自显影方法结合神经毒对海马神经元的选择性损毁观察AVP4_。结合点在大鼠海马内的分布和定位;利用外源性AVP,_a对新生大鼠的处理,观察海马AVP4_。

It was found by means of protein fluorescence detection that the number of MAP-2 masculine neurone in the hippocamp of AD rat in model group and zinc reinforce post-AD group decreased distinctly. There was not distinct difference in the MAP-2 expression and the number of MAP-2 masculine neurone between normal group and zinc reinforce pro-AD group.

模型组和AD后补锌组大鼠海马区MAP-2蛋白表达与正常组大鼠相比显著下降,MAP-2蛋白荧光检测发现模型组和AD后补锌组大鼠海马区MAP-2阳性神经元数量明显减少,AD前补锌组大鼠海马区MAP-2蛋白表达和MAP-2阳性神经元数量与正常组相比差异无显著性。

PKC and GDNF were all decreased in hippocampi of model rats, there may be some relations between them.

穹隆海马伞切断AD大鼠海马PKC和GDNF均降低,这表明在AD海马有PKC和GDNF变化发生,说明在AD这两者之间存在一定的联系。

Objective: To investigate the difference of PEBP mRNA expression between the fimbria-fornix transected and normal side hippocampi.

目的:探讨切割穹窿海马伞侧大鼠海马与正常侧海马中PEBP mRNA 的表达差异。

In this study,we choosed the landmarks with invariableness and easy identification which can be accepted by most scholastics.We can provided the normal volume of hippocampus and its subregion by MRI measurement and basement of pathogenesis of depression disorder by investigating hippocampal volume and shape characteristics of the depression.

由于海马的分部和边界勾画比较混乱,本文根据解剖学标志选择原则,确认易区别、较为恒定并能为大多数人所接受的勾画标志点;通过测量,提出正常海马及其亚区体积的参考值;并研究抑郁症的海马形态体积及其病理学变化,为探讨抑郁症发病机制提供依据。

Based on the results, it has found that six distinct layers can be identified from lateral to medial in the olfactory bulbs, and the adults have more cells than the subadults. Ventricles of the adults take up larger vacuity, have richer choroids plexus, and primordial pallium and primordial hippocampus of them are more developed than the subadults, in which the primordial piriform is well-developed. Ventral to the primordial hippocampus, there is a septal area which can not be divided into medial and lateral parts in both adults and subadults, nor there is lateral limiting sulcus to separate the primordial piriform and the corpus striatum, but only in the subadults, a medial limiting sulcus can be clearly identified to separate the primordial hippocampus and the septal area. Besides, the corpus striatum of Onychodactylus fischeri is paleostriatum. The cell group that located at two sides of the third ventricle is amygdale, and shape and size of neurons within the telencephalon are poorly differentiation.

结果表明:爪鲵嗅球内细胞从外到内大致可分为6层结构,亚成体的细胞数量少于成体;成体爪鲵的侧脑室所占空间较大,脉络丛更为丰富,原始大脑皮层和原始海马都比亚成体发达,后者大脑内原始梨状区较为发达;隔区位于原始海马的下方,成体和亚成体都没有外侧隔核和内侧隔核之分,也没有外侧界沟作为原始梨状区和纹状体的分界,而在亚成体的侧脑室壁有内侧界沟区分原始海马和隔区,成体则没有;此外,爪鲵的纹状体属于古纹状体,杏仁核是位于第三脑室两侧的两个细胞团,端脑内细胞形态和大小分化较为单一。

The experiment research indicates: contrasting with thecontrol groups, Bushen Huoxue Huatan Prescription has the following functions: 1. improving the praxiology function of model rats, 2. improving the activity in cholineacetyl-transferase in hippocampus tissue, 3. increasing the expression of NOS in hippocampus region of cortex, 4. promoting the expression of the synapse P3, in hippocampus region of cortex, 5. reducing obviously the apoptosis number of brain nerve cell .

实验研究表明:与对照组比较,补肾活血化痰方具有:1、改善动物行为学功能;2、提高海马组织胆碱乙酰转移酶活性;3、增加皮质及海马区一氧化氮合酶的表达;4、促进皮质海马区突触素蛋白P_(38的表达;5、显著降低脑神经细胞的凋亡数目。

Methods OA was injected into hippocampal CA1 region of rats. We observed rat praxiology changes by Morris water maze and the senile plaques and neurobrillary tangles of hippocampus by Bielschowsky stain and the expression of β-amyloid protein and neuronal nitric oxide synthase of the rats hippocampus by immunohistochemistry.

在大鼠海马CA1区多次微量注射OA,水迷宫实验观测大鼠行为学改变;Bielschowsky染色观察海马CA1区神经原纤维缠结和老年斑等特征性病理变化;免疫组化方法观察海马CA1区Aβ1-40和nNOS的表达。

Transported by axoplasmic flow into somata, NGF plays an important role in the development, preservation and survival of cholinergic neuron in BF.

药物损伤BF的胆碱能神经元,或切断穹窿海马伞使隔-海马的纤维投射破坏可导致海马θ节律消失和记忆能力减退。

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