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Results For single treatment groups,serum drug concentration of chlorpromazine and clozapine were related to age of patients (P<0 05),concentration of clozapine was related to dosage (P=0 01).For combination group,concentration of chlorpromazine was related to dosage (P<0 01),also related to scores of PANSS and general psychopathological symptoms (P=0 01),concentration of clozapine was related to scores of PANSS,negative and general psychopathological symptoms (P<0 05).Multiple linear regression analysis showed that forms and methods of treatment affected concentration of chlorpromazine,age of patients and methods of treatment affected concentration of clozapine.

结果 单用氯丙嗪和采用氯氮平组的血药浓度均与年龄相关(P<0 05),氯氮平血药浓度与剂量线性正相关(P=0 01);在双氯组中的氯丙嗪血药浓度与剂量线性正相关(P<0 01),与PANSS总分及一般精神病理分相关(P=0 01),而氯氮平血药浓度与PANSS总分、阴性量表分及一般精神病理分明显相关(P<0 05);多元回归分析显示,治疗形式和治疗方法影响氯丙嗪血药浓度,年龄和治疗方法影响氯氮平血药浓度

The hydrophobic monomers such as glycidyl octyl dimethylammonium chloride, glycidyl dodecyl dimethylammonium chloride, glycidyl tetradecyl dimethylammonium chloride was applied to the hydrophobic modification of two kinds of sodium cellulose sulfate in isopropyl alcohol under 65℃.The success of synthesis of a kind of novel amphoteric surfactant by FT-IR and NMR. 3. By the measuring surface tension of all kinds of amphoteric polymeric surfactants based on cellulose, the critic micelle concentration was obtained such as 0.4wt%、0.3wt%、0.25wt% and corresponding surface tension was about 30mN/m

通过动态接触角测量仪确定了各种纤维素表面活性剂的表面张力和临界胶束浓度,结果表明该类表面活性剂可与小分子表面活性剂的降低表面张力的能力相媲美,最低可达28.41 mN/m,随着疏水基中碳链的增长,降低表面张力的能力下降,而临界胶束浓度从0.4wt%相应降低0.25wt%;应用环境扫描电镜确定其不同浓度胶束形态,结果表明在较低浓度下形成棒状单分子胶束,随着浓度的升高,单分子胶束逐渐聚集成树枝状胶束,进一步提高浓度,则聚集成网状结构;此外,采用了高级流变仪对其溶液的流变性质进行了研究,结果表明其溶液属于剪切变稀流体,是高分子溶液特有的性质。

Results: 1. The value of all experimental indexes decreased significantly after heat stress, and reached the lowest at the time 2-8 hours after heat stress. This indicates that the immunity of the mice is damaged to the largest extent at 2-8 hours after heat stress. 2. L-arginine supplementation with appropriate dose could remit the acute atrophying of thymus and spleen tissue caused by heat stress. 3. After L-arginine supplementation with appropriate dose, the lymphocyte proliferation, the level of concentration of IL-2 and * expression of IL-2R raised in the group with room temperature; in the heat stress group the level of three indexs decrease significantly. Furthermore, the decrease of the group given 1 .Smglg.bw L-arginine is the smallest. This result indicates that the concentration of 1 .Smglg.bw L-arginine supplementation could remit the depressment of the immunity caused by heat stress. 4. The [Ca2~] in activated thymocytes of the group with L-arginine -2- supplementation is significantly higher than that of the group with water supplementation. This indicates that L-arginine supplementation could protect thymoeytes of mouse under heat stress. We also found that the fluorescence intensity of [Ca2~] in activated thymocytes of the group given 1 .Smglg.bw L-arginine is the highest.

结果:1、热应激后小鼠的各项免疫指标均有显著性下降,其中在2.8小时降到最低,提示在这个时间段小鼠的免疫功能受到最大损害;2、适量补充精氨酸有助于缓解热应激导致小鼠胸腺和脾脏的急性萎缩;3、常温组,补充适量精氨酸后小鼠淋巴细胞增殖活性、IL-2的浓度及IL-2R的表达均有显著性上升,而热应激后三指标均显著降低,其中在精氨酸给予浓度为1.5mg/g.bw时三指标的降低程度最少,提示该浓度可最大程度缓解热应激对小鼠免疫功能的抑制;4、补充精氨酸组的活化胸腺细胞[Ca~(2+)]较给水组有显著性上升,说明精氨酸对热应激小鼠胸腺细胞具有保护作用,并发现在精氨酸给予浓度为1.5mg/g.bw时活化胸腺细胞的胞浆钙离子荧光强度达到最大;5、热应激后小鼠血清NO的浓度均有不同程度的上升,补充精氨酸后血清NO上升更加明显,但并非随精氨酸给予浓度的增加而增加。

An attempt was made to remove color from simulated wastewaters containing Acid Scarlet GR and Reactive violet K-3R by cloud point extraction using a nonionic surfactant of Triton X-114. The influence of the concentrations, equilibrium temperature and equilibrium time on the extraction efficiency was tested. The experimental results show that the extraction efficiency to dye increases with increasing concentration of TX-114 and salt or decreasing initial dye concentration.

本文选用非离子表面活性剂TX-114作浊点萃取剂,研究了由酸性大红与活性紫构成的单元和二元混合染料模拟有色废水的萃取脱色过程,讨论了表面活性剂浓度、染料浓度、盐浓度、平衡温度、平衡时间等因素对萃取效率的影响结果表明,提高表面活性剂浓度、盐浓度有利于提高萃取效率,而染料浓度增加则使萃取效率略有下降。

The experimental results indicates that the optimum pH range was 1.60~2.20, and the optimum H2O2 concentration was 10.0 mmol/L. The degradation ratio increased with the increasing concentration of ammonium ferric oxalate in the range from 0.1 to 1.0 mmol/L, but no significant increase in degradation ratio was observed when the concentration was above 1.0 mmol/L. When the concentration of fuchsin basic increased, the degradation ratio dropped, while the concentration of degraded fuchsin basic rised. When the concentration of fuchsin basic was low, the degradation followed first-order kinetics, but when it was high, the degradation could be fitted by zero-order kinetics. The absorbtion of fuchsin basic at 543 nm disappeared quickly, while the absorbtion of intermediates formed during the course of fuchsin basic dagradation at 298 nm vanished slowly.

试验结果表明:碱性品红降解的最佳初始pH为1.60~2.20,最佳初始H2O2浓度为10.0mmol/L;草酸高铁铵的浓度在0.1~1.0mmol/L时,碱性品红的降解率随浓度的增大而增大;高于1.0mmol/L时,则降解率相差不大;碱性品红的初始浓度增大,降解率减小,而实际降解的浓度则增加;碱性品红的浓度在低和高时,降解动力学过程不一致;随降解的进行,碱性品红在可见光区的吸收峰迅速消失,而降解过程中形成的中间产物吸收峰却消失很慢。

That is mean, weak acids tend to have lower milk/plasma concentration ratios and higher concentrations in milk, such as anticoagulants, antimetabolites, antithyroid agents, atropine, bromides, cathartics, ergot, iodides, mercurials, metronidazole, narcotics, and radioactive agents.

乳汁中药物浓度大部分较母体循环中药物浓度低,例如哺乳期妇女服用红霉素、磺胺类、异烟肼、甲硝唑,乳汁中各药物浓度约为血清中该药物浓度的50%,而青霉素、头孢菌素在乳汁中的浓度仅不足血清中该药物浓度25%。

Sowe selected the colchicine optimum parameters were 0.6μg/ml and 6 hour culturedduration.The second, there were no significantly differences between the four groupsin 2 hour groups; and there were significantly differences between 0.2μg/ml groups and other three groups in 4 hour groups; and there were no significantlydifferences between the four groups in 6 hour groups; and there were significantlydifferences between 0.4μg/ml groups and other three groups in 8 hour groups onthe metaphases (P<0.05), in the experiment of the effect on the mouse 8-cellembryo stage single blastomere of colchicine with different concentrations andduration by x~2 statistical analysis.

根据实验的实际情况,适宜制备小鼠4-细胞期胚胎单卵裂球染色体标本的秋水仙素的处理浓度和时间是0.6μg/ml和6小时。2、在确定秋水仙素不同处理浓度和时间对小鼠8-细胞期胚胎单卵裂球中期分裂相数影响的实验中,经统计分析,阻断培养2小时组中四个浓度组差异均不显著;阻断培养4小时组中0.2μg/ml浓度组与其他三组差异显著;阻断培养6小时组中四个浓度组差异均不显著;阻断培养8小时组中0.4μg/ml浓度组与其他三组差异显著(P<0.05)。

So we selected thevinblastine optimum parameters were 0.1μg/ml and 8 hour cultured duration.The fourth, there were significantly differences percent between 10 hourgroups and other three groups in 0.1μg/ml groups; and there were no significantlydifferences between 8 hour groups and 10 hour groups, but they had significantlydifferences among other two groups in 0.3μg/ml groups; and there weresignificantly differences between 10 hour groups and other three hour groups in0.5μg/ml groups; and there were significantly differences between 10 hour groupsand other three groups in 0.7μg/ml groups on the metaphases (P<0.05), in theexperiment of the effect on the mouse 8- cell embryo stage single blastomere ofvinblastine with different concentrations and duration, by x~2 statistical analysis.

根据实验的实际情况,适宜制备小鼠4-细胞期胚胎单卵裂球染色体标本的长春花碱的处理浓度和时间是0.1μg/ml和8小时。4、在确定长春花碱不同处理浓度和时间对小鼠8-细胞期胚胎单卵裂球中期分裂相数影响的实验中,经统计分析,阻断培养0.1μg/ml浓度组中10小时组与其他三组差异显著;阻断培养0.3μg/ml浓度组中8小时组和10小时组间差异不显著,但与其他两组差异显著;阻断培养0.5μg/ml浓度组中10小时组与其他三组差异显著;阻断培养0.7μg/ml浓度组中10小时组与其他三组差异显著(P<0.05)。

So we selected the colchicine optimumparameters were 0.2μg/ml and 6 hour cultured duration.The third, there were significantly differences percent between 10 hourgroups and other three groups (4 hour groups, 6 hour groups and 8 hour groups) in0.1μg/ml groups; and there were significantly differences between 8 hour groupsand 10 hour groups, but they had no significantly differences among other twogroups in 0.3μg/ml groups; and there were significantly differences between 10hour groups and 6 hour groups, but 10 hour groups had no significantlydifferences among other two groups in 0.5μg/ml groups; and there weresignificantly differences between 8 hour groups and other three groups in0.7μg/ml groups on the metaphases (P<0.05), in the experiment of the effect onthe mouse 4- cell embryo stage single blastomere of vinblastine with differentconcentrations and duration, by x~2 statistical analysis.

根据实验的实际情况,适宜制备小鼠8-细胞期胚胎单卵裂球染色体标本的秋水仙素的处理浓度和时间是0.2μg/ml和6小时。3、在确定长春花碱不同处理浓度和时间对小鼠4-细胞期胚胎单卵裂球中期分裂相数影响的实验中,经统计分析,阻断培养0.1μg/ml浓度组中10小时组与其他三组差异显著(4小时组、6小时组和8小时组);阻断培养0.3μg/ml浓度组中8小时组和10小时组间差异不显著,但与其他两组差异显著;阻断培养0.5μg/ml浓度组中10小时组与6小时组差异不显著,而与其他两组差异显著;阻断培养0.7μg/ml浓度组中8小时组与其他三组差异显著(P<0.05)。

Results: Good linearity was observed in 6~1512μmol.L-1 range for phenylalanine, the intra-run and inter-run imprecisions w ere 3.68%and 4.01%, the recovery rate was 98.6%; good linearity was observed in 5.4 ~1380.0μmol.L-1 range for tyrosine, the intra-run and inter-run i mp recisions were 1.87%and 2.59%, the average recovery rate was 98.9%.

酪氨酸的线性范围为5.4~1380μmol.L-1,最低检测浓度为0.7。μmol* L-1,平均回收率98.9%,批内CV为1.87%,批间CV为2.59%。健康儿童血清苯丙氨酸浓度为(61.4±10.8)μmol.L-1,血清酪氨酸浓度为(131.8±28.0)μmol.L -1。健康成人血清苯丙氨酸浓度为(69.3±8.6)μmol.L-1,血清酪氨酸浓度为(83.6±9.4)μmol.L-1.4例苯丙酮尿症患儿的血清苯丙氨酸浓度为1296~1759μmol.L-1,血清酪氨酸为29.5~53.5μmol.L-1。

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