浆细胞瘤

Through all this test analyse Pathogenicity and Immunological status of ALV-J Inner Mongolia strain, the result showed the infected chickens began to have pathological change of Myelcytomatosis at 3-week: the main pathological changes of acidophile myelocyte were found in bone marrow and between cardiac muscle fibers,and there were many granules in the hyalotome.This kind of oncocyte proliferated in every tissue at different amount, but the cells that proliferated in bone marrow, cardiac muscle fiber, oarium were much more than other tissue, and they often developed neoplasma. At same condition,there were no abnormalty advent in control group, In immunological aspect: the increase of lymphokine and ANAE positive cells showed cell-mediated immunity was strengthend during antineoplastic infection; the emergence of ALV-J antibody of ELISA suggest there was humoral immunity exist at the same time.

结果显示：脾脏PCR检测结果表明1、2两实验组均有阳性病例出现，而对照组全部为阴性，说明实验鸡体内已有ALV-J内蒙株感染；接种病毒后3周龄开始出现骨髓细胞瘤病的病理变化：肝脏、脾脏有程度不同的肿大，镜下观察，骨髓内最早出现了与骨髓细胞相似、形态基本一致的大型圆形或椭圆形、胞核较大多为椭圆形、胞浆内含有大量嗜酸性圆形颗粒的髓细胞样瘤细胞增生，随后通过血流瘤细胞可转移到肝脏、心肌、卵巢或睾丸等组织并形成肿瘤性病灶，而对照组没有出现明显病变；免疫状态方面：以脾脏淋巴因子和ANAE阳性细胞增多说明细胞免疫在抗肿瘤感染过程中增强，ELISA检验实验鸡抗体出现阳性的结果表明同时也存在着体液免疫。

And yet, the pathogenesis of the syndrome is not fully understood. Its possible pathogenesis is relative to plasmocytoma, autoimmunization, human herpesvirus 8 infection and so on.

目前病因和发病机理还不完全清楚，可能与浆细胞瘤、自身免疫、人类疱疹病毒8感染等因素有关。

On the basis of observation on the denucleation process of mammalian erythroid cells in vito and in vitro, the present study was designed to investigate the regulatory effect and its mechanism of mammalian erythroblast cytoplasmic factor on malignant phenotype and gene expression of hybrid cells formed by cellular engineering fechnique of cell hybridization between the mouse plasmocytomas SP (2/0) cell line and rat erythroblasts.

本研究选用正常大鼠中幼、晚幼成红细胞与小鼠浆细胞瘤（SP2/0）细胞进行异种细胞杂交，研究哺乳动物红细胞胞质因子对肿瘤细胞恶性调控的效应及其机制。

The individual tumor cells had striking morphologic overlap with plasma cells with an eccentrically placed nucleus and abundant amphophilic to eosinophilic cytoplasm.

这些浆细胞样的瘤细胞在形态上都与正常浆细胞十分相似：核偏位，胞浆丰富、嗜双色性或嗜酸性。

Objective: To abserve the therapeutic effect of the anaplastic plasmacytoma patient receiving non-myeloablative hematopoietic stem cell transplantation.

目的：观察非清髓异基因外周血造血干细胞移植治疗间变性浆细胞瘤的疗效。

This result indicates that WT1 gene plays an important role in differentiation and development of fetal kidney and may be the factor that promotes metanephric blastemal cell to differentiate into epithelial cell.

结果显示小胎龄肾组织中WT1蛋白在胚基细胞和幼稚肾小球细胞核表达而大胎龄组肾组织中WT1在肾小管细胞胞浆表达，阳性率分别为57.1％(8/14)和46.2%(6/13)，提示WT1基因在胚胎肾分化发育的过程中起着重要作用，WT1蛋白可能是促进后肾胚基细胞向上皮细胞分化的调控因子，其表达在时间上和空间上都受到严格的调控，WT1的表达异常可能导致胚基细胞分化停滞。17例肾母细胞瘤WT1蛋白表达阳性率为41.2%(7/17)，阳性部位在胚基型和上皮型肿瘤细胞核，表达部位和阳性率与早期胚胎肾相似，其中间质型肾母细胞瘤均为阴性，胚基型和上皮型肾母细胞瘤阳性率70%(7/10)，两组间阳性率有显著差异。

None of the GISTs, desmoid tumors, inflammatory myofibroblastic tumors, schwannomas, dedifferentiated liposarcomas, or malignant peripheral nerve sheath tumors showed cytoplasmic reactivity for smoothelin.

所有GISTs、韧带样纤维瘤、炎性肌纤维母细胞瘤、神经鞘瘤、去分化脂肪肉瘤和恶性外周神经鞘膜瘤病例的瘤细胞浆均不表达smoothelin。

Sphenoid sinus pituitary adenoma is rare and can be misdiagnosed as sphenoiditis or plasmocytoma. The diagnosis is dependent on histopathologic analysis and immunohistochemical staining.

原发于蝶窦的垂体腺瘤比较少见，主要根据光镜及免疫组化确诊，应注意与慢性蝶窦炎和浆细胞瘤鉴别。

Studies on the regulation of malignant phenotype expression in a mouse plasmocytoma cell line (SP2/0) by means of cellular engineering techniques of cell hybridization between the fusion of the mouse myeloma cells with rat intermediate or late erythroblasts.

三、利用细胞杂交的细胞工程手段，首次系统地研究了大鼠中幼、晚幼成红细胞与小鼠浆细胞瘤（SP2/0）细胞融合后恶性表型的表达状态，分析自然去核前红细胞胞质对骨髓瘤细胞恶性增殖的调控作用，以及晚幼期固缩核重新被激活的可能性。

Many tumor specific antigens such as mouse PlA, human MAGE, BAGE and GAGE families had been isolated during recent decade. PlA is a tumor specific antigen expressed by mouse mastocytoma P815. It is one kind of cancer-testis antigens and expresses in various mouse tumor such as mastocytoma P815, plasmoma J558 and fibrosarcoma Meth A but hardly in normal tissue except testis and placenta.

近十年来已经成功分离出多种鼠或人的肿瘤特异性抗原，如小鼠P1A基因和人的MAGE、BAGE、GAGE家族等。P1A为小鼠肥大细胞瘤P815所表达的肿瘤特异性抗原，它是一种CT抗原，在多种小鼠肿瘤如肥大细胞瘤P815、浆细胞瘤J558和纤维肉瘤Meth A等中表达，而在除睾丸、胎盘之外的正常组织中不表达。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐