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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

The relationship between activity of catalyst and crystalline structure, and surface traits was associated via some characterizations.

根据反应活性与结构性能的研究结果,提出了在碳化钼催化剂上的POM反应机理。

The activity of enzyme production of bacteria from the soil samples that from oil refinery was higher, and the best carbon source for bacteria fermenting and producing lipase was sucrose, and the best nitrogen source was beef extract.

结论]炼油厂土样中细菌的产酶活性较高,细菌发酵产脂肪酶的最佳碳源为蔗糖,最佳氮源为牛肉膏。

Under the optimum conditions, the analytes could be separated within 17 min in a 75 cm length capillary at a separation voltage of 18 kV in a 10 mmol/L borate buffer (pH 8.2). A 300 μm diameter carbon disk electrode generated a good response at+ 0.95 V vs. saturated calomel electrode (SCE for all analytes. The relationship between peak currents and analyte concentrations was linear over about three orders of magnitude with detection limits (S/N=3) ranging from 78 μg/L to 110 μg/L for all analytes.

在优化的实验条件下,以直径300μm的碳圆盘电极为工作电极,检测电位为+0.95V,在10mmol/L硼酸盐(pH8.2)的运行缓冲溶液中,上述6种活性成分能在17min内实现很好的基线分离,被测物浓度与峰电流在3个数量级范围呈良好的线性关系,检出限(S/N=3)范围为78~110μg/L。

An assay for carbonic anhydrase enzyme, which is thought to play an important role in the process of bio-calcification revealed novel activity.

在对生物钙化过程中起重要作用的碳酸酐酶的分析中显示了此酶的新颖的活性。

Carboxyhemoglobin level in the artery blood, malondialdehyde content and superoxide dismutase activity in the lung, heart, liver and kidney were detected. The 24-hour survival rate of rats was studied.

测定各组心、肺、肝和肾组织匀浆中丙二醛含量、超氧化物歧化酶活性及血液内碳氧血红蛋白的变化,观察动物 2 4小时存活率。

The carboxyhemoglobin levels of in-flowing pulmonary blood and out-going pulmonary blood were determined at 2,4 and 6 hours after treatments. Malondialdehyde contents and superoxide dismutase activities in the lung,liver and blood were also determined. Pathological changes in lung and liver were examined with light microscope,and immunohistochemical technique was used for analysis of heme oxygenase-1 (HO-1) protein expression and distribution in lung and liver.

各组分别在制模后2、4和6 h测定出入肺血中碳氧血红蛋白水平;肺、肝组织及血液中丙二醛含量及超氧化物歧化酶活性;光镜下观察肺、肝组织形态学改变;免疫组化分析血红素加氧酶-1(HO-1)在肺、肝组织中的蛋白表达和分布。

How to improve its catalytic activity is one of the difficult points and the hot topics in recent years.

如何提高其催化活性是碳化钨应用研究所面临的主要难点与热点之一。

The suitable synthesis conditions of those new products have been studied. The structures of them are affirmed by IR spectroscopy, 1~H NMR,(13)~C NMR and Elemental Analysis;the configurations of them are also analyzed by theoretical calculation of quantum chemistry. Influences of the length of hydrophobic group, the degree of substitution on the solubility, surface activity, emulsifying property, foam property, hygroscopicity and humidity-retaining ability, compatibleness of those new products have been studied in detail.

探讨了各反应产物的适宜合成条件,并利用红外吸收光谱、1~H、(13~C核磁共振、元素分析等仪器分析手段和量子化学从头算STO-3G对所得产物的结构进行了表征;同时较详细地研究了疏水基碳链长度、反应取代度对合成产物的溶解性、表面活性、乳化性、泡沫性、吸湿保湿性和配伍性等物化性质和应用性能的影响规律。

The invention provides a fuel cell carbon platinum-carried compound catalyst with small amount of platinum and high catalytic activity, and a preparation method thereof.

本发明提供了一种铂用量少且具高催化活性的燃料电池碳载铂复合催化剂及其制备方法。

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