活性核

Reactive dye not only can covalently bind with modified flax by nucleophilic reaction, but also can form electrovalent bond. Attracting among hydronium is of benefit to nucleophilic reaction.

改性亚麻与活性染料之间即可发生亲核取代反应形成共价键结合，又可形成离子间的库仑力，而且离子间的相互吸引更有利于染料上的活性基与纤维素发生亲核取代反应。

Now we have known that SARS-CoV encoded 11 varietal proteins. They have 4 constitutive proteins: spike protein, membrane protein, envelope protein and nucleocapsid protein. Spike protein trimer form spike and exsertion? virus peplos on the surface. Spike protein is archi-surface antigen component of virus, it has acceptor binding and membrane fusion activity. Spike protein has important effect at tissue tropism, cell-fusion and toxicity. Nucleocapsid protein can bind genome RNA to shape neucleocapsid. Membrane protein and envelope protein are necessary constituent to shape virus peplos. Spike protein is I-type membrane glycoprotein, it mediate virus binding with host cell epimembranal acceptor and to fuse host cell membrane.

SARS-CoV属于巢状病毒目、冠状病毒科，为单正链RNA病毒，基因组全长约29.7kb，已知编码11种蛋白，其中包括4种结构蛋白，分别是刺突蛋白、包膜蛋白、小包膜蛋白和核蛋白或核壳体蛋白。S蛋白三聚体形成突起，伸出包膜表面。S蛋白是病毒的主要表面抗原成分，具有受体结合和膜融合活性，在组织嗜性、细胞融合和毒力等方面起重要作用。N蛋白与基因组RNA结合形成核衣壳。M蛋白和E蛋白是包膜形成所必需的成分。

However, about 25% of cases exhibit frank malignant features of prominent nuclear pleomorphism, mitotic activity or necrosis.

然而，大约25%的病例显示恶性特征诸如明显核多型现象、核分裂活性或者坏死。

Marked changes of apoptosis including condensation of chromatin and nuclear fragmentation were observed very clearly by Hoechst 33258 fluorescence staining and a characteristic "ladder" of DNA fragments was elicited by agarose gel electrophoresis; Western blot analysis revealed that caspase-3 was activated by the loss of caspase-3 proenzyme (32kDa) and the appearance of its 20kDa subunit, and that along with the apoptotic process caspase-3 activity was increased concurrently.

Hoechst 33258荧光染色观察到典型的核浓缩、核碎裂等细胞凋亡的形态学变化，琼脂糖凝胶电泳观察到细胞凋亡时的DNA"梯形"条带；Western blot检测结果表明32kDa的caspase-3酶原被激活，出现20kDa的亚单位活化片段，同时在细胞凋亡过程中，caspase-3活性显著增高。

Results］the gross morphology of the tendons showed the experimental group had lesser adhesion and better reactiveness than that in the control group.the fibrin had degraded at 3 weeks. cell tracing showed that the labeled bone marrow derived mesenchymal stem cells remained viable and presented in the intratendinous region for at least 6 weeks, becoming more diffuse at later timepoints.at 3 weeks, collagen fibers appeared more organized and there were better morphometric nuclear parameters in the treatment group. at 6 and 12 weeks, there were no differences between the groups with regard to morphometric nuclear parameters.

结果］实验组相比对照组肌腱大体观察粘连差，肌腱活动性好。3周后纤维蛋白载体即降解，细胞示踪结果显示标记的骨髓间充质干细胞至少6周内仍可保持活性并存在于肌腱组织中，但之后逐渐扩散。3周时，实验组与对照组相比胶原纤维排列更为有序，且胞核形态结构更规则，但在6周及12周时，实验组与对照组胞核参数测定无统计学意义。3周时实验组比对照组具有更强的的生物力学特性，但之后则差别不明显。

On the one hand, one benzen ring of stilbene was substituted by one pyridine ring for the purpose of evaluating the bioactivities of azastilbenes. On the other hand, some stilbene derivatives with different substituents in different sites were designed for the study of SAR.

一，以吡啶环替代母核的一个苯环，考察分子中引入氮原子对活性的影响；二，改变母核上的取代基类型及取代位点，考察取代基在构效关系中的影响规律。

NF-κB is a kind of important nuclear factors which are relative to lots of cellular activities such as activation of immunocyte, development of T and B lymphocyte, stress reaction, cell apoptosis and so on. NF-κB exists in almost all types of cytoplasm in the unreactive form of heterodimer or homodimer.

核转录因子κB(nuclear transcription factorκB， NF-κB)是一类关键性的核转录因子，通常以同源或异源二聚体非活性形式存在于几乎所有类型细胞的胞质，其与免疫细胞的活化，T，B淋巴细胞的发育，应激性反应，细胞凋亡等多种细胞活动有关。

This experiment adopted lipoic amido dehydrogenase histochemistry method and image pattern analysis technique to investigate the relationship between nitric oxide synthase neurons and activity of NOS and auditory threshold, and to explore the possible role of NOS neurone in cochlear nuclei of guinea pigs after exposed to white noise.

采用硫辛酰胺脱氢酶组织化学方法及图象分析技术，研究白噪声暴露后豚鼠耳蜗核一氧化氮合酶神经元及NOS活性的变化与听阈的关系，探讨豚鼠耳蜗核NOS神经元在白噪声损伤过程中可能的作用。

This experiment adopted lipoic amido dehydrogenase histochemistry method and image pattern analysis technique to investigate the relationship between nitric oxide synthase neurons and activity of NOS and auditory threshold, and to explore the possible role of NOS neurone in cochlear nuclei of guinea pigs after exposed to white noise.

提要 采用硫辛酰胺脱氢酶组织化学方法及图象分析技术，研究白噪声暴露后豚鼠耳蜗核一氧化氮合酶神经元及NOS活性的变化与听阈的关系，探讨豚鼠耳蜗核NOS神经元在白噪声损伤过程中可能的作用。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。