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Three kinds of small molecular copper and zinc superoxide dismutase mimics were synthesized with N, N-bis (benzimidazol-2-ylmethyl) amine (N3), N, N-bis (benzimidazol-2-ylmethyl) methylamine(MN3) and N,N-bis (benzimidazol-2-ylmethyl) benzylamine(BN3) as ligands. The com-plexes were characterized by UV, IR and element analysis and the structures were proposed.

模拟铜一锌超氧化物歧化酶的活性中心,以二(2-苯并咪唑)丙烷为桥、二(2-苯并咪唑亚甲基)胺(N3)、二(2-苯并咪唑亚甲基)甲胺(MN3)及二(2-苯并咪唑亚甲基)苄胺(BN3)为配体合成了3种异双核的小分子模型化合物,并进行了紫外、红外表征及元素分析,推测了可能的结构。

The results show that these binuclear complexes have greater activity than cisplatin against cisplatin-insensitive HCT8 cell line.

其结果显示这些双核配合物对顺铂不敏感的人结肠癌瘤株HCT8显示出较好活性。

The antitumor activity of some water-soluble binuclear Pt or Pd complexes have been determined in vitro.

测定了一些水溶性的双核铂或钯配合物体外抗肿瘤活性。

The dissertation systematically studied the influences of modification on binuclear catalyst structures and polymerization conditions on catalytic activity and properties of polymer obtained.

本文系统研究了双核后过渡金属催化剂结构和聚合条件对催化活性以及聚合产物性质的影响规律。

In combination with Ni_2 as phosphate scavenger, binuclear nickel complex displayed high catalytic activity for the polymerization of ethylene.

以Ni_2为瞵攫取剂,该双核中性水杨醛亚胺镍化合物对乙烯聚合显示出较高的催化活性,并考察了聚合反应条件对其催化性能的影响。

Methods Thirteen new isoflavone derivatives with α-methy-lene-γ-butyrolactone ring at C-7 were designed and synthesized with 7-hydroxyisoflavone as starting material, and their inhibition on the adherence of human neutrophils was tested.

以7-羟基异黄酮衍生物为原料,合成了13个未见文献报道的新化合物,用人多形核白细胞黏附性实验检测目标化合物的活性。

This study suggests that the increase of nNOS in caudatum may play a role in improvement of locomotor disability. SVHRP exerts neuroprotection in MPTP-treated C57BL/6 mice via decreasing nNOS in the caudatum.

结论SVHRP可以保护中脑黑质致密部多巴胺能神经元及改善MPTP引起的运动协调性降低,逆转MPTP引起的尾核nNOS免疫反应活性增强。

These excellent properties of 9E-BHVC all mentioned above imply that it would be a true two-photon nucleic acid fluorescent probe if it can specially recognize the DNA in complex cellulous environment.So this dissertation has investigated the ability of 9E-BHVC on the cell nucleus imaging detaily.

与BMVC相比,9E-BHVC表现出作为双光子荧光探针更好的特性,例如具有更大的活性吸收截面和更高的结合常数,且具有更好的水溶性。9E-BHVC这些优良的性质预示着该分子如果能够在复杂的细胞环境中特异性地识别DNA,那么它将是真正意义的双光子核成像探针。

Compared to BMVC,9E-BHVC has many better features needed by a two-photon probe,such as larger two-photon action cross sections,stronger affinity to DNA and better water-solubility.These excellent properties of 9E-BHVC all mentioned above imply that it would be a true two-photon nucleic acid fluorescent probe if it can specially recognize the DNA in complex cellulous environment.So this dissertation has investigated the ability of 9E-BHVC on the cell nucleus imaging detaily.

与BMVC相比,9E-BHVC表现出作为双光子荧光探针更好的特性,例如具有更大的活性吸收截面和更高的结合常数,且具有更好的水溶性。9E-BHVC这些优良的性质预示着该分子如果能够在复杂的细胞环境中特异性地识别DNA,那么它将是真正意义的双光子核成像探针。

Methods Density gradient centrifugalization and absorption technique were respectively applied to detach peripheral blood mononuclear cells and peripheral blood lymphocytes.

密度梯度离心及吸附法分离外周血单个核细胞和外周血淋巴细胞,采用抗CD4和CD8抗体分别制备CD~(8+)和CD~(4+)T细胞进行培养,应用MTT比色法及ELISA法分别检测T细胞增殖活性及培养上清液IL-2水平。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

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