洛贝林

Chris Bangle, Director of Design, BMW Group Peter Barna, Provost, Pratt Institute Yves Behar, Founder, fuseproject Katherine Bennett, IDSA Education Vice-President, and Professor of Product Design, Art Center College of Design Mark Breitenberg, Dean of Undergraduate Education, Art Center College of Design, and Chair of the Education Committee, International Council of Societies of Industrial Design Heather Fraser, Director, Business Design Initiative, Rotman School of Management, University of Toronto Tamara Giltsoff, Live | Work Walter Herbst, Director, Master of Product Development Program, McCormick School of Engineering and Applied Science, and Professor of Marketing, Kellogg School of Management, Northwestern University Barry Jaruzelski, Vice-President, Innovation Practice, Booz Allen Hamilton Chuck Jones, Vice-President, Global Consumer Design, Whirlpool Lorraine Justice, Professor and Head of Hong Kong Polytechnic University, School of Design Larry Keeley, President, Doblin Inc. David Kelley, Founder of IDEO, and Co-founder of Stanford s Hasso Plattner Institute of Design Claus Knapheide, Director of User Experience, Siemens Mick Malisic, Director of Marketing, Frog Design Brian Matt, Founder, CEO, Altitude Dev Patnaik, Founder, Jump Associates Ravi Sawhney, CEO-President, RKS Design Jeff Semenchuk, EVP, Global Consumer Group Innovation, Citigroup RitaSue Siegel, President, RitaSue Siegel Resources Bob Sutton, Professor of Management Science and Engineering, and Co-founder of Stanford s Hasso Plattner Institute of Design Sohrab Vossoughi, President, ZIBA Design Patrick Whitney, Director, Institute of Design, Illinois Institute of Technology Gianfranco Zaccai, President and CEO, Continuum

克里斯手镯，设计，宝马集团董事彼得巴纳，教务长，普拉特学院伊夫贝哈尔，方正，fuseproject 凯瑟琳贝内特，IDSA的教育副总统，以及产品设计，艺术中心设计学院教授马克布赖滕贝格，本科教育，艺术中心设计学院，以及教育委员会，国际工业设计协会理事会主席迪安石南弗雷泽，主任，业务设计倡议，罗特曼管理，多伦多大学塔玛拉Giltsoff，直播|工作沃尔特赫布斯特，主任，产品开发计划，麦考密克工程和应用科学学院硕士，以及市场营销，Kellogg管理，西北大学法学院教授巴里雅鲁泽尔斯基，副总统，创新实践，博思艾伦查琼斯，副总裁，全球消费者设计，惠而浦洛林司法，教授和香港理工大学校长，设计学院拉里开利，总裁，德布林公司大卫凯利，IDEO的创始人兼联合创始人斯坦福虏哈索普拉特纳设计学院克劳斯Knapheide，用户体验，西门子公司董事米克马利希奇，市场营销，青蛙设计总监布赖恩马特，创始人，CEO，海拔 dev的帕特奈克，方正，跳转协会拉维梭尼，首席执行官，总裁，设计可胜杰夫谢缅丘克，执行副总裁，全球消费者集团创新，花旗集团 RitaSue西格尔先生，RitaSue西格尔资源鲍勃萨顿，管理科学与工程学院教授，兼联合创始人斯坦福虏哈索普拉特纳设计学院苏赫拉布Vossoughi，总统，Ziba设计帕特里克惠特尼主任，设计，伊利诺斯技术研究所詹弗兰科扎卡伊，总裁兼首席执行官，连续

Nobel peace laureates Elie Wiesel, John Hume, David Trimble, Jody Williams, F.W. de Klerk, Mairead Maguire, Betty Williams and Adolfo Perez Esquivel signed the letter along with about 40 celebrities and rights activists including Ford, Paltrow, Peter Gabriel, Richard Gere, Mia Farrow, Maria Bello, Adam Yauch of the Beastie Boys, Ashley Judd, supermodels Christy Turlington and Naomi Campell and Queen Noor of Jordan.

诺贝尔和平奖获得者，伊利威塞尔、约翰休姆、大卫林布尔、乔迪威廉斯、德克勒克、马奎尔、贝蒂威廉斯，以及阿道弗佩雷基韦尔，都已经在这封信上签了名，同样这样做的还有约40位社会名流和活动家，他们包括福特、帕特洛、彼得盖布瑞尔、李察基尔、米亚法罗、玛利亚贝洛、"野兽男孩"组合中的亚当亚奇、阿什莉贾德、超模克里斯蒂特灵顿、纳奥米坎贝尔、以及约旦王后努尔。

The fluorescence intensity of lobeline-treated cells was significantly higher than that of the controls, when the concentration of lobeline was more than 10 μmol/L.

洛贝林（20 μmol/L）的多药耐药逆转有效率为经典耐药逆转剂维拉帕米（20 μmol/L）的71.6%，但毒副作用显著降低。

ObjectiveTo explore the reversal effect and mechanism of lobeline on the multidrug-resistance of human breast cancer cells MCF-7/ADM.

目的：探讨哌啶生物碱洛贝林对人乳腺癌多药耐药细胞株MCF-7/ADM耐药的逆转作用及其分子机制。

Taking untreated MCF-7/ADM cells as controls,flow cytometry was applied to detect the intracellular concentration of rhodamine123 in MCF-7/ADM cell intervened with lobeline of 20 μmol/L.

同时用流式细胞术检测洛贝林对MCF-7/ADM细胞内罗丹明123积聚浓度的影响，从功能学的角度观察洛贝林的耐药逆转作用及其机制。

Fluorospectorphotometer was employed to investigate the intracellular concentration of rhodamine123 to reflect the effect of lobeline on the activity of MDR-related protein P-glycoprotein.

多功能酶标仪测定洛贝林干预对细胞内罗丹明123荧光强度以反映其对细胞多药耐药蛋白P-gp活性的影响。

With fewer side effects, the reversal efficacy of 20 μmol/L lobeline was 71.6% of the classical MDR reversal agent of verapamil at the same concentration. ConclusionLobeline can reverse the MDR of MCF-7/ADM cells by inhibiting the activity of P-glycoprotein.

洛贝林对乳腺癌多药耐药细胞株MCF-7/ADM的耐药性具有逆转作用，其机制主要为抑制细胞多药耐药蛋白P-gp的活性

Chiral separation of nine enantiomers, which include lobeline, tropicamide, promethazine,propranolol, atenolol, cyclandelate, salbutamol, fenfluramine and benzhexol, has been for the first time achieved by nonaqueous capillary electrophoresis.

用非水毛细管电泳成功地分离了洛贝林、托吡卡胺、普萘洛尔、阿替洛尔、环扁桃酯、沙丁胺醇、苯海索、芬氟拉明和异丙嗪等9种手性化合物。

Our company supply raw materials and related intermediates as follows: Second dibutyryl cAMP calcium, voriconazole, terbinafine, vecuronium amines, cAMP, thiamphenicol, a chlorophenol hydrochloride esters, card network sodium phosphate tilmicosin, foscarnet, lornoxicam, Tilmicosin, Cephalosporium aspirin acid, ceftiofur hydrochloride, ceftiofur sodium, Ozagrel, ondansetron hydrochloride ketones, hydroxyurea, ticarcillin sodium, telmisartan, esmolol hydrochloride, hydrochloric acid Daguan Nikkomycin, adefovir dipivoxil, buflomedil hydrochloride, granisetron hydrochloride, warfarin sodium,-methyl gabexate acid, nicergoline, pantoprazole sodium,·, tegafur, cefepime hydrochloride, vecuronium bromide, hydrochloric acid meclofenoxate, sertraline hydrochloride, Cefonicid amine salt, aztreonam, ticarcillin, cefdinir, cefodizime sodium, sodium ferulate, colloidal pectin secretion, 2,3 - cyclopentene and pyridine, Piperacillin acid, cefetamet US-acid, hydrochloride Cefmenoxime ,3-TZ, 2 - deoxy-D-glucose, two-amidine urea benzene, sodium Cefonicid, Cefonicid intermediates, ester Cefamandole sodium, Cefalotin acid, intermediates cefpirome, cefepime sulphate, cefepime intermediate nucleus of cefepime, cefpirome nucleus, Cefamandole sodium, ceftriaxone new active ester, oxaliplatin, cyclophosphamide vary gland amines, polyene match him.

我公司供应的原料药及相关中间体为：二丁酰环磷腺苷钙、伏立康唑、盐酸特比萘芬、维库溴胺、环磷腺苷、甲砜霉素、盐酸甲氯酚酯、卡络磺钠、磷酸替米考星、膦甲酸钠、氯诺昔康、替米考星、头孢匹胺酸、头孢噻呋盐酸盐、头孢噻呋钠、奥扎格雷、盐酸恩丹西酮、羟基脲、替卡西林钠、替米沙坦、盐酸艾司洛尔、盐酸大观霉素、阿德福韦酯、盐酸丁咯地尔、盐酸格拉司琼、华法林钠、甲磺酸加贝酯、尼麦角林、泮托拉唑钠、普拉洛芬、替加氟、盐酸头孢吡肟、维库溴铵、盐酸甲氯芬酯、盐酸舍曲林、头孢尼西胺盐、氨曲南、替卡西林、头孢地尼、头孢地嗪钠、阿魏酸钠、胶体果胶泌、2，3-环戊烯并吡啶、哌拉西林酸、头孢他美酸、头孢甲肟盐酸盐、3-TZ、2-脱氧-D-葡萄糖、双脒苯脲、头孢尼西钠、头孢尼西中间体、头孢孟多酯钠、头孢噻吩酸、头孢匹罗中间体、头孢吡肟硫酸盐、头孢吡肟中间体、头孢吡肟母核、头孢匹罗母核、头孢孟多钠、头孢曲松新型活性酯、奥沙利铂、异环磷腺胺，多烯他赛。

Sublingual formulation of lobe line sul fate does not appear to be an effective smoking cessation aid .

舌下含服硫酸洛贝林制订似乎不是一个有效的帮助戒烟。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。