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The results showed that NO level and NOS activity was significantly increased in rat liver,kidney,heart and muscle after recurrent administration intraperitoneal of 50mg/kg cerous nitrate,at the same time,NO level was increased in rat liver and kidney after administration of 1mg/kg cerous nitrate.

结果显示,腹腔注射高浓度的稀土后,大鼠肝脏、心脏、肾脏、骨骼肌中一氧化氮、一氧化氮合成酶的水平明显增加,注射低浓度的稀土后,肝脏、肾脏内一氧化氮的量显著增加。

The results showed that Ca2+-ATPase, K+,Na+-ATPase and Mg2+-ATPase activity was increased in rat liver, kidney and heart after recurrent intraperitoneal administration of low dose of cerous nitrate(1mg/kg),but no changes happened for these enzymes activity after high cerous nitrate administration(50mg/kg).

结果显示,连续腹腔注射低浓度硝酸铈后,大鼠肝脏、肾脏、心脏等组织中Ca2+-ATP酶,K+、Na+-ATP酶,Mg2+-ATP酶活性明显增强;而当注射高浓度硝酸铈时,酶活性均未发生明显变化。

Methods 60 female mice were randomly divided into 4 groups (n=15):Mice in normal control group received subcutaneous injection of normal saline and mice in the other 3 groups received cervicodorsal injection of D-galactose[1000 mg/(kg1·d)] for 42 d to establish subacute aging model.

60只雌性昆明种小鼠,随机分为4组(n=15):正常对照组皮下注射生理盐水;其余3组每日颈背部皮下注射 D-半乳糖[1000 mg/] 造成小鼠衰老模型,同时各组分别灌胃生理盐水、枸杞多糖[200 mg/]、丹参酮[1 500 mg/]。42 d后,测定小鼠背部皮肤组织匀浆中超氧化物歧化酶活力、过氧化脂质代谢产物丙二醛含量和皮肤羟脯氨酸含量。

objective to compare the anti-aging effects of lycium barbarum polysaccharides and tanshinone on the skin of d-galactose-induced mice aging model.methods 60 female mice were randomly divided into 4 groups (n=15):mice in normal control group received subcutaneous injection of normal saline and mice in the other 3 groups received cervicodorsal injection of d-galactose[1000 mg/(kg1·d)] for 42 d to establish subacute aging model.the experimental groups included agingmodel group,lycium barbarum polysaccharides [200 mg/group,tanshinone [1 500 mg/] group.forty two days later,the dorsal skin samples were collected to determine sod activities、mda and hydroxyproline contents.

目的 比较枸杞多糖与丹参酮对衰老小鼠皮肤的抗衰老作用。方法 60只雌性昆明种小鼠,随机分为4组(n=15):正常对照组皮下注射生理盐水;其余3组每日颈背部皮下注射 d-半乳糖[1000 mg/]造成小鼠衰老模型,同时各组分别灌胃生理盐水、枸杞多糖[200 mg/]、丹参酮[1 500 mg/]。42 d后,测定小鼠背部皮肤组织匀浆中超氧化物歧化酶活力、过氧化脂质代谢产物丙二醛含量和皮肤羟脯氨酸含量。

objective to compare the anti-aging effects of lycium barbarum polysaccharides and tanshinone on the skin of d-galactose-induced mice aging model.methods 60 female mice were randomly divided into 4 groups (n=15):mice in normal control group received subcutaneous injection of normal saline and mice in the other 3 groups received cervicodorsal injection of d-galactose[1000 mg/(kg1·d)] for 42 d to establish subacute aging model.the experimental groups included agingmodel group,lycium barbarum polysaccharides [200 mg/group,tanshinone [1 500 mg/] group.forty two days later,the dorsal skin samples were collected to determine sod activities、mda and hydroxyproline contents.

60只雌性昆明种小鼠,随机分为4组(n=15):正常对照组皮下注射生理盐水;其余3组每日颈背部皮下注射 d-半乳糖[1000 mg/]造成小鼠衰老模型,同时各组分别灌胃生理盐水、枸杞多糖[200 mg/]、丹参酮[1 500 mg/]。42 d后,测定小鼠背部皮肤组织匀浆中超氧化物歧化酶活力、过氧化脂质代谢产物丙二醛含量和皮肤羟脯氨酸含量。

The results are as follows: Both genistein and CNQX attenuated the ventilatory responses of peripheral chemoreflex, while no changes occurred following daidzein. The amplitude of integrated phrenic nerve discharge and the phrenic burst frequency were decreased by (-21.77±6.93%) and (-24.70±7.61%) respectively after administration of genistein.

结果显示,吸入低氧混合气后,动物呼吸加深加快;在NTS 处微量注射CNQX或genistein 都会不同程度削弱外周化学感受性反射引起的通气反应,而微量注射daidzein后对反射没有影响。

The ventilatory responses of the peripheral chemoreflex following microinjection within the NA of either P2X receptor agonist adenosine triphosphate or antagonist pyridoxal-5′-phosphate-6-azo-phenyl-2, 4-disulfonate were observed.

结果 吸入低氧混合气后,动物呼吸加深加快;在NA处微量注射ATP增强了急性低氧呼吸频率,微量注射PPADS部分阻断了ATP对低氧通气的兴奋效应。

The normal choriocapillaris of the New Zealand rabbit was used to test photodynamic effect by HMME, which dose was HMME 5mg/kg body weight and was activated by 532nm laser with fluence of 20, 30, 45 and 60 J/cm within 10 seconds after intravenous injection of HMME.

①以新西兰兔正常脉络膜毛细血管层为实验对象,HMME注射剂量为5mg/kg,波长532nm激光作为激发光源,眼底光斑功率密度为200、300、450和600mW/cm~2,照射时间为100s,照光时机为注射药物结束后10s。

Therefore, in the present study, a retrograde and anterograde experiments were made in the rat to address this issue. After injection of cholera toxin B subunit, a retrograde tracer, into Barrington's nucleus or D-region, some retrogradely labeled neurons were found in lamina I, sacral parasympathetic nucleus and dorsal commissural nucleus of the lumbosacral spinal cord segments. Injection of biotinylated dextran amine into lamina I, sacral parasympathetic nucleus and dorsal commissural nucleus, respectively, a large number of BDA-labeled axon terminals were seen in Barrington's nucleus and D-region.

发现,将逆行示踪剂霍乱毒素 B 亚单位( Cholera toxin B subunit; CTb )注射到 Barrington's 核或 D 区后,在大鼠腰骶髓 I 层、骶髓副交感核和后连合核内分布有一定数量的 CTb 逆标神经元;将顺行示踪剂结合生物素的葡聚糖胺(Biotinylated dextran amine; BDA)分别注射到腰骶髓 I 层、骶髓副交感核和后连合核内后, Barrington's 核和 D 区内出现大量顺行标记的轴突终末。

Iii. Process Water cont'd Type 3 Water - Purified Water (e.g., USP Purified Water), in Europe the EMEA refers to this a Highly Purified Water - Most difficult to control microbial levels, because no preservative chlorine is present in the water -Less expensive to produce than Water for Injection Type 4 Water - The most critical quality level -Commonly used in final formulation for parenteral applications -Must satisfy the Water for Injection specification as laid out in compendia such as the USP iii.

工艺水 第3类型水-纯化水,在欧洲,EMEA称为高纯水。-控制微生物水平最困难,因为水中没有防腐的氯。-与注射用水比较,生产成本较低第4类型水-最高质量要求-通常用于非肠道用药的最后制剂中-必须符合诸如美国药典这类法定文本中描述的注射用水的规格

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