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One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活,ICAM-1表达升高,与被激活的PMN表面表达的LFA-1相结合,"PMN-EC"相互作用加剧,一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍;另一方面粘附的PMN过度吞噬或激活,当白细胞吞噬的颗粒不能被封闭隔离,连同细胞内的酶被释放出来,其中的PMN-elastase能够降解细胞基质中各种成分,水解多种蛋白,加重胰腺的毛细血管内皮细胞和腺泡的损伤;释放的溶酶体酶使组织蛋白水解,产生的不饱和脂肪酸引发脂质过氧化方应,破坏细胞膜的结构和功能;释放的炎性细胞因子,激发其他的免疫细胞的功能,导致进一步的组织损伤和坏死,加重SAP的病理损伤,最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Leaves scattered; petiole 3–5 mm, densely spreading rust-colored setose; leaf blade elliptic-ovate, ovate, or oblong-lanceolate, 8–16 × 4–9 cm, papery-leathery, abaxially very densely rust-colored setulose, especially on veins, adaxially bullate, densely shortly setulose, immediately glabrescent, secondary veins 2 pairs arising from base, fine veins distinctly raised abaxially, impressed adaxially, base shallowly cordate to rounded, margin slightly revolute, sparsely dentate,± setiform-ciliate, apex acuminate, caudate, or acute. Inflorescences axillary, racemose or corymbose, 1–4 cm, ca. 10-flowered, densely tomentulose; bracts rhombic-triangular, 5–8 × 4–5 mm, leathery, densely tomentulose.

叶星散 叶柄3-5毫米,密被平展锈色具刚毛;叶片椭圆状卵形,卵形,或者长圆状披针形, 8-16 * 4-9 厘米,纸质革质,背面非常浓密锈色具小刚毛,在脉上的特别是,正面具泡状隆起,具小刚毛的密被短的,立即后脱落,次脉2 对生于基部,清楚的细脉背面突起,正面凹陷,基部浅心形到圆形,花序腋生,总状或伞房状,1-4厘米,约10花,密被被微绒毛;苞片菱形三角形, 5-8 * 4-5 毫米,革质,密被被微绒毛。

The result indicates the t-BHP or diamide both cause the mass loss about the membrane protein thiol in hepatocytes, the fast oxidization about glutathione in hepatocytes, the leakage of lactate dehydrodenase, but the level of t-BHP is larger than of diamide. In the aspect of lipid peroxidation, only the t-BHP produces apparent change. As to actin and tubulin, they both find fall-off and present time-dependency effects. The result in Confocal fluorescent microscope also show these two cytoskeletal proteins are related to cell blebbing, but they don''t play the same role during the porcess. Tubulin may be more important than actin. If the study predispose dithiothreitol before adding t-BHP or diamide, then the damage by the diamide is repressed, but just partly protection for the damage by t-BHP.

结果显示t-BHP或diamide均可造成细胞膜蛋白硫醇大量流失与胞内GSH快速氧化,亦显著导致乳酸去氢□渗漏,但t-BHP诱发的渗漏程度大於diamide;在脂质过氧化方面,则仅t-BHP处理组产生明显的脂质氧化情形;至於肌动蛋白与管蛋白单体均可见减少且呈现时间依赖效应;在雷射共轭焦萤光显微镜观察中,亦显现这两种架构蛋白与细胞膜起泡有关,但两者在小泡生成的过程中扮演的角色并不完成相同,可能管蛋白较肌动蛋白重要;如果细胞在t-BHP或diamide加入前预先以dithiothreitol处理,则diamide 所造成的伤害显著的受到抑制,但DTT对t-BHP所诱发的伤害则仅有部分保护效果。

In addition, the mitochondria showed no signs of swelling and the nuclear membrane remains intact. Multiple membrane-bound apoptotic bodies and engulfment of cell debris and corpses by phagocytes were observed at 24h, while extensive cell loss appeared at 48h. These results demonstrated the occurrence of high level of apoptosis by 24h postdosing.

相应的超薄切片在电子显微镜下得到结果与光镜下一致,24h前线粒体形态结构无明显变化,主要有染色质浓缩、边集及分割,以及内质网空泡化和凋亡小体的形成;24h后可观察到线粒体的肿胀和扩张,细胞发生崩解和死亡。

During the secondary wall formation of fiber, H+-ATPase, Ca2+-ATPase and APase also sustainablely remained in plasma membrane, plasma membrane invagination, plasmodesmata, transfer vesicles and agglutinated nucleus.

在次生壁形成的整个过程中,ATP酶、Ca2+-ATPase和酸性磷酸酶在运输小泡、细胞膜、质膜内陷、胞间连丝和凝聚的染色质中将持续存在。

Results: The main ultrastructural changes after Cd treatment included swelling or vacuolation of mitochondria, increase of myelin figures in GCT cells, and swelling of mitochondria in the endothelial cells of peritubular capillaries. The changes above were most prominent at 7~15d, and swelling of the cytoplasm and slight karyolysis were also found. The morphology of GCT cells didn't recovery to normal yet after 30d.

结果:镉注射后24h,GCT细胞内出现不同程度的线粒体肿胀和空泡化,胞质和线粒体内可见髓样结构,GCT周围毛细血管内皮细胞线粒体肿胀。7~15天后上述改变明显加重,部分GCT细胞见胞质广泛肿胀和轻度核溶解,30天后细胞形态仍未恢复正常。

In resting cysts, the microtubules under the pellicle, cortical ciliatures, conjunctions between cilia basal bodies, supporting structure of basal bodies and other microtubule structures are absorbed in different extent; microtubule-like assemble bodies appear at the center of the remained cilia basal bodies; the granules of chromatin and nucleolus in macronucleus become smaller whereas nucleus pores of the micronucleus become bigger; the inner membrane of some nucleus pores are attached with chromatin.

结果表明:纤毛虫形成包囊过程中,皮层细胞质中产生具有自噬泡消化特征的细胞器,将部分纤毛结构等逐步消化;休眠包囊中,表膜下微管、皮层纤毛器和纤毛基体间连接、基体托架及其他微管结构不同程度地被吸收、在残剩纤毛基体的中央形成微管形结构聚合体,大核染色质和核仁颗粒变小,核孔增大,并发生染色质附着于核孔内膜的现象;细胞脱包囊期间,皮层细胞骨架、线粒体等经历了在残剩结构基础上的再分化。

Steep and cover Steep and put on tower record whether chemical industry use most early one typical drum modes in Chinese operatic music tower plate of steeping etc., Two occupy the leading status among the quality equipment according to legend in distillation, absorb,etc..

泡罩塔盘是化学工业中使用最早的一种典型的鼓泡型板式塔盘,在蒸馏、吸收等两相传质设备中占有主导地位。

Steep and put on tower record whether chemical industry use most early one typical drum modes in Chinese operatic music tower plate of steeping etc., Two occupy the leading status among the quality equipment according to legend in distillation, absorb,etc..

泡罩塔盘是化学工业中使用最早的一种典型的鼓泡型板式塔盘,在蒸馏、吸收等两相传质设备中占有主导地位。

All I want is a proper cup of coffee made in a proper copper coffee pot, you can believe it or not, but I just want a cup of coffee in a proper coffee pot. Tin coffee pots or iron coffee pots are of no use to me.

不管你信不信,我想要的就是一杯真正的用特有的铜质咖啡壶做的咖啡,但是我仅要用铜质咖啡壶泡的咖啡,锡质或铁质的咖啡壶泡的我都不要。

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I didn't watch TV last night, because it .

昨晚我没有看电视,因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来,在北京的很多小区里,电梯液晶电视被撤了下来。

I'm running my simile to an extreme.

我比喻得过头了。