泡质

Vacuoles and black dense particles usually occurred in cytoplasm of heterokaryon, and occasionally, swelling of mitochondria, pycnotic nuclei or even enucleation process could be seen among hybrid cells.

超微结构分析表明，杂交细胞表面膜微绒毛、指状突及皱褶突等均明显减少，核内异染色质比例增高，核仁数目减少或消失，细胞质中常可见有空泡或黑色致密颗粒出现；少数杂交细胞出现线粒体肿胀、核固缩甚至排核现象。

Ultrastructurally, the changes commonly seen were hydropic mitochondria and dilatation of rough endoplasmic reticulum.

超微结构观察显示线粒体肿胀破裂，粗面内质网扩张囊泡化和脱颗粒。

Results:Whith the time and doses of ART incubation extended, ART significantly inhibited the proliferation of SGC-7901 cells and the inhibited effect shows dose-and -time-dependent. Obvious changes of apoptotic morphology were observed by invert microscope, fluorescence microscope, scanning electron microscope and transmission electron microscope, they showed that cells had marked nuclear condensation or the fragmentation of chromation as well as apoptotic , mitochondrial edema and vesicle , with the time of incubation extended , the proliferation rate become slow and the volume became small and transformed. FCM assay indicated that most of the cells were arrested in Go/Gi and the apoptotic peak appeared. During the prolong of incubation time, the apoptosis rate was increased. At the same time, the number of S and G2/M phase cells were decreased. The result of TUNEL indicant that there are apoptosis and necrosis.

结果：随着药物浓度的增加和作用时间的延长，蒿甲醚对胃癌SGC-7901细胞的抑制作用呈时间和浓度依赖关系：在倒置显微镜、荧光显微镜、扫描电镜和透射电镜下可观察到典型的凋亡细胞的形态改变，表现为：核固缩或染色质边聚或凝聚成大块状，可见凋亡小体，线粒体肿胀增殖，严重的空泡化，随作用时间的延长，细胞增殖速度减慢，细胞体积缩小变形；流式细胞术显示胃癌SGC-7901细胞出现明显的凋亡峰，随着作用时间的延长，其凋亡率逐渐升高，细胞周期阻滞在G_0/G_1期，S及G_2/M期细胞数大量减少；流式细胞术TUNEL检测结果显示细胞凋亡和坏死同时存在。

RESULTS: There were many vacuoles and cracks in the cells, with heterochromatin margination, nuclear pycnosis and nuclear fragmentation. The high intensity pulsed electric fields caused damage in K562 cells, and the apoptotic percentage went up with the increase in frequency and intensity of PEF.

结果：经过高电压脉冲电场处理后的K562细胞，胞内出现大量空泡及裂隙，核内染色质向核周边聚集形成凋亡小体，呈典型细胞凋亡形态学改变；K562癌细胞的凋亡比例随着脉冲个数和电场强度的增加而增加。

Observ ed with transmission electron microscope and scanning electron microscope, t he apoptotic nuclei showed the typical morphological feathers of apoptosis: cond ensation and margination of chromatin, bubbling of nuclear membrane and apoptoti c bodies.

在透射电子显微镜和扫描电子显微镜下都观察到凋亡的细胞核呈现典型的凋亡形态学特征，例如染色质的凝集及趋边化，细胞核表面形成空泡化结构并有大量的凋亡小体结构出现。

In light and electronic microscopy, they appeared cell shrinkage, cell density increasing and eosinophilic, aggregation of cytoplasmic organelles, nucleolus fragmentation, and chromatin margination, condensation, and fragmentation. Those changes could be detected by TUNEL method.

在光镜和电镜下癌细胞凋亡表现为细胞体积缩小，胞浆浓缩嗜酸性，胞浆出泡、细胞器缩小或减少，核仁松解，染色质聚集、靠边、浓聚、断裂，在TUNEL法检测凋亡癌细胞时也可观察到相应的形态特点。

Results: Resveratrol significantly ihibited growth and proliferation of SW480 cells in time and dose dependent manner.Resveratrol perturbed cell cycle,and arrested SW480 cells in S-phase accompanied with reducing G2-phase cells.The ultrastructural change of the SW480 cells treated with resveratrol were as following:the number of microvilli on the surface ofplasm membrance decreased and the nucleolar margination was frequent in nucleus.

结果：白藜芦醇能抑制SW480细胞的生长增殖，并呈时间浓度依赖性；白藜芦醇能影响SW480细胞的细胞周期分布，使细胞周期阻滞于S期，G1期细胞减少；经白藜芦醇处理的SW480细胞可出现细胞超微结构的改变：可见染色体边聚，细胞表面突起减少，胞质内空泡化等凋亡形态的变化。

Heregulin-αwas a cytokine which was synthesized and secreted by mammary mesenchyme,adjacent to lobuloaveolar structures.

Heregulin-α是主要由乳腺间质细胞合成和分泌的细胞因子，作用于乳腺导管和腺泡上皮细胞。

Objective To investigate the effect of gene transfection of FKBP12.6 on cardiac function and pathological changes of canine heart failure induced by rapid ventricular pacing.

目的探讨白蛋白微泡介导的pcDNA3.1-FKBP12.6质粒转染对心衰犬心功能及心肌病理变化的影响。

Toxin could caused plasmolysis, the vacuous mitochondrion and plasmalemma breakage etc.

可引起水稻愈伤组织细胞质壁分离、线粒体双层膜与嵴模糊、线粒体空泡化、质膜断裂等受害情况。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。