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Methods 24 SD rats were randomly divided into normal group,model group,aminophylline treatment group(35 mg/kg), 8 rats in each group. The bronchial asthma model in rats was built by egg protein sensibilization and longterm inhalation provocation. The rats in treatment group were lavaged each day from the first time of provocation.After 4week treatment, the rats were killed to obtain lung tissue for staining with HE.

24只SD大鼠随机分为正常组、模型组、治疗组,每组8只,除正常组外以卵蛋白致敏并吸入激发法制备大鼠哮喘模型,治疗组、模型组从第1次哮喘激发开始(造模第3周)分别给予氨茶碱、0.9%氯化钠溶液灌胃给药,1次/d,用药4周处死大鼠,取肺组织HE染色,用彩色图像分析仪测量支气管壁面积、支气管平滑肌面积,用ELISA双抗体夹心法测定肺组织MMP9和TIMP1含量。

Objective and Methods To evaluate mechanisms of drugs commonly used in the treatment of septicemia, giving antibiotics including Minocycline (10 mg/kg), Clindamycin (10 mg/kg), Cyclosporin (15 mg/kg) and Platonin (10 mg/kg) to septicemic rat injected with LPS. Clinical improvement, blood pressure, heart rate, survival time are assessed, and the amount of endogenous NO production is determined.

本实验之目的是要探讨在临床上常用於治疗败血症的数种药物,可能的作用机转;藉由注射老鼠LPS模拟败血症前,先给予Minocycline,Clindamycin,Cyclosporin,Platonin等药物治疗,评估药物的改善状况,同时观察血压、心跳、动物存活时间及侦测体内NO的生成量,来比较给药与否之差异,且针对变化的可能原因来探讨。

Lei olive jade plates vegetables, Gong vegetables, oil sweetfish products are sold in Southeast Asia and other senior condiments and pickles; mentor tong medicine health food Chongji homology is a treatment and health care in a home standing supplies, especially " Liang Jinsheng,"" Four Seasons Ganlu "products, is a manufacturer for several decades of experience to make well-formed, to healing and treatment of dual-use purposes.

玉蕾牌的橄榄菜、贡菜、红油香鱼等产品是销往东南亚的高级调味品和酱菜;恩师堂的药食同源保健冲剂是集治疗和保健于一身的居家常备用品,特别是&金声亮&、&四季甘露&产品,是集生产厂家几十年经验而成的精良之作,达到养身和治疗两用的目的。

Topotecan is an effective agent for SCLC when used as monotherapy or in combined treatment, but myelosuppression such as leucopenia and thrombopenia was relatively severe. Although it has been recommended as a second-line agent for recurrence of sensitive SCLC, more clinical trials are needed to define its role in first-line treatment.

拓扑替康治疗小细胞肺癌有确切临床疗效,无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效,但具有相对高的致白细胞和血小板下降的骨髓毒性,已被认为是治疗化疗敏感的小细胞肺癌患者复发的二线推荐药物,但是作为一线用药仍然需要更多的实践来证实。

Conclutions Topotecan is an effective remedy for treatment of small cell lung cancer, both single topotecan and combined regimen has the same effect as the traditional first-line regimen, though myelo-suppression such as leucopenia and thrombopenia is more sever, the adverse effect is tolerated. Though it has been recommended as second-line agent for chemo-therapy sensitive small cell lung cancer, there needs more clinical studies to verify its role in first-line.

结论拓扑替康是在小细胞肺癌的治疗中有确切临床疗效的药物,无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效,虽具有相对高的致白细胞和血小板下降的骨髓毒性,但毒副作用可耐受,已经被认为是治疗对化疗敏感的小细胞肺癌患者的二线推荐药物,但是作为一线用药仍然需要更多的临床证据来证实。

Optimal treatment of gout requires both non-pharmacological and pharmacological modalities and should be tailored according to: specific risk factors (levels of serum urate, previous attacks, radiographic signs); clinical phase (acute/recurrent gout, intercritical gout, and chronic tophaceous gout); general risk factors (age, sex, obesity, alcohol consumption, urate elevating drugs, drug interactions and comorbidity).

痛风最佳治疗需药物和非药物治疗手段相联合,并根据以下情况调整:(1)特殊的危险因素(血尿酸水平,以前发作情况和放射线表现);(2)临床阶段(急性/复发性痛风,发作间歇期痛风和慢性痛风石性痛风);(3)一般危险因素(年龄、性别、肥胖、饮酒、增高尿酸药,药物相互作用和合并疾病)。

Specific risk factors (levels of serum urate, previous attacks, radiographic signs); clinical phase (acute/recurrent gout, intercritical gout, and chronic tophaceous gout); general risk factors (age, sex, obesity, alcohol consumption, urate elevating drugs, drug interactions and comorbidity).

痛风最佳治疗需药物和非药物治疗手段相联合,并根据以下情况调整:(1)特殊的危险因素(血尿酸水平,以前发作情况和放射线表现);(2)临床阶段(急性/复发性痛风,发作间歇期痛风和慢性痛风石性痛风);(3)一般危险因素(年龄、性别、肥胖、饮酒、增高尿酸药,药物相互作用和合并疾病)。

A specific risk factors (levels of serum urate, previous attacks, radiographic signs); clinical phase (acute/recurrent gout, intercritical gout, and chronic tophaceous gout); general risk factors (age, sex, obesity, alcohol consumption, urate elevating drugs, drug interactions and comorbidity).

痛风最佳治疗需药物和非药物治疗手段相联合,并根据以下情况调整:(1)特殊的危险因素(血尿酸水平,以前发作情况和放射线表现);(2)临床阶段(急性/复发性痛风,发作间歇期痛风和慢性痛风石性痛风);(3)一般危险因素(年龄、性别、肥胖、饮酒、增高尿酸药,药物相互作用和合并疾病)。

Effect of Fufangdanshendiwan for the treatment of vascular dementia has obvious effects, in particular, together with other puzzle drugs; can significantly slow down the process of vascular dementia; Fufang Danshen Diwan also use simple, the medication compliance Good, safe, vascular dementia can use the Effect of Fufangdanshendiwan treatment, in clinical worth promoting.

复方丹参滴丸用于治疗血管性痴呆有明显的疗效,尤其是联合其他益智药,能够明显延缓血管性痴呆的进程。复方丹参滴丸用法简单,服药的依从性好,安全性高。因此,血管性痴呆可以使用复方丹参滴丸治疗,在临床上值得推广。

Patients in Group A ( n = 48) discontinued intake of antiplateletdrugs for at least 7 days and served as controls, patients inGroup B ( n = 11) received aspirin 100 mg/d and those in GroupC ( n = 11) aspirin 100 mg/d and clopidogrel 75 mg/d until the day before surgery.

A 组患者( n = 48)至少停用抗血小板药7天,作为对照组, B 组患者( n = 11)接受阿司匹林治疗100 mg/天, C 组患者( n = 11)接受阿司匹林治疗100 mg/天及氯吡格雷75 mg/天直到手术前一天。

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