治疗药

The invention relates to the isolation and preparation of an active fraction from plant Cuminum cyminum, its further purification and standardization as chemically defined entity with their intended use as drug bioavailability enhancer for the drugs belonging to therapeutic categories such as antimicrobial, antifungal, anti-viral, antitubercular, antileprosy, anti-inflammatory, antiarthritic, cardiovascular, antihistaminics, respiratory distress relieving drugs, immunosuppressants, anti-ulcerogenic, anti-cancer, CNS drugs, corticosteroids, nutraceuticals in compositions to be administered orally/parenterally, topically, inhalations, rectally, vaginally in human beings and/or veterinary conditions.

本发明涉及植物孜然芹中的一种活性级分的分离和制备，进一步的纯化以及它作为化学确定实体的标准化，和它作为治疗类药物的生物利用率增强剂的特定用途，这类药物包括如抗微生物剂、抗真菌剂、抗病毒剂、抗结核药、抗麻风病药、抗炎药、抗关节炎药、心血管类药、抗组胺药、呼吸窘迫缓解药、免疫抑制剂、抗溃疡药、抗癌药、CNS药、皮质甾类药、营养制品，它们以组合物的形式通过口服/肠胃外，局部，吸入直肠，阴道施用于人和/或兽医学病症中。

Advance basic research has confirmed that the alkaloids extracted from thunberg fritillary bulb which is widely used in clinical medicine in vitro and in animal experiments have reversed MDR of leukemia. It will increase resistance of acute leukemia cells anticancer drug concentration and lower resistance the expression of Pgp. Pre-Clinical Experimental Research also shows that the conventional chemotherapy combined with the powder of thunberg fritillary bulb for the treatment of acute leukemia. Clinical complete response rate was higher, especially for patients with refractory or relapsed leukemia patients better clinical remission rate. In addition, Caladium particles Slices with chemotherapy in the treatment of RAL Clinical studies also show the Chinese refractory leukemia improve clinical efficacy safe and reliable.

先期基础研究已证实：临床常用的化痰散结中药浙贝母提取的生物碱体外及动物实验均有逆转白血病多药耐药的生物活性，能增加耐药的急性白血病细胞内抗癌药物浓度，降低耐药蛋白Pgp的表达；临床预实验研究也表明，常规化疗方案配合浙贝母粉用于急性白血病临床治疗，其临床完全缓解率明显高于对照组，尤其对难治及复发白血病患者临床缓解率更佳；此外，单药浙贝母颗粒配合化疗治疗RAL的临床研究亦显示中药在提高难治性白血病临床疗效方面安全可靠。

There is no significouldt variation between the function of Method 1 and 3 in the indexes of digestive and absorptive function,except the effect on body weight and food intake;as well,model 2 shows no significouldt influence on the indexes besides body weight lose.1.4 ConclusionsContrast the three modeling methods,model 3 is the most obvious and steady method for the establishment of deficiency of spleen YANG.2 comparison on the efficacy of Lizhong Pills influenced by dried ginger and its different components on digestive and absorptive functions and energy metabolism2.1 ObjectivesThis research was designed to observed the different influences of Lizhong Pills formula on the models,which contains dried ginger or its main group of components(volatile oil and water solubles).It would be explored from two levels of material base,single herb dried ginger or its different components,to confirm that the whole effects of Lizhong Pills do mainly depend on its main herb dried ginger in the formula just as the traditional acknowledgement in TCM.Further more,the connotative meaning of dried ginger used as the main herb in Lizhong Pills egthe aspect of pharmacology and chemistry would be preliminary revealed.2.2 MethodsEach group of model rats of deficiency of spleen-YANG were to be duplicated by method 3 for 14 days,and be treated by corresponding drug samples for 8 days.

造模方法1对消化吸收相关药理指标的改变与造模方法3的影响相似，但对模型动物的体重和食量的影响不明显；造模方法2除能使模型动物的体重减轻外，对其他各指标均无显著影响。1.4结论对比实验采用的三种石膏-知母的给药方法，方法3的造模效果最为显著和稳定，即以每日灌胃给药，连续12天，恢复9天，是本实验证实的最有效的脾阳虚证候模型制备方法。2干姜及其不同有效部位对理中丸消化吸收功能及代谢的影响2.1目的通过对理中丸中君药干姜，以及干姜中挥发性成分和水溶性成分对理中丸主要功效影响的研究，从药味和化学成分群两个层次，证实君药干姜及干姜中的主要活性成分群对理中丸整体功效的决定性影响，以初步揭示理中丸中君药核心地位的药理学和化学内涵。2.2方法采用石膏-知母复合造模法制备大鼠脾阳虚证候模型，造模期为14天1；治疗期间各给药组分别给予治疗药物，连续给药8天。

2 Treatment method is less than a month treat a little patient to use method of massage drop medicine first, treat 1~2 week, 2~3min is massaged before daily drop medicine, be more than the little patient of a month, if drop medicine treats 1~2 week to did not see,improve to still have apparently weep the person that reach secretion, applied medicaments pressurization rinses lachrymal path, use pinhead of vein of skin of tube head of nylon of self-restrained and different type to grind blunt, make rinse a needle continuously, groovy operation, after syringe needle inserts lachrymal canaliculus, nylon the canal is secured with adhesive plaster at the head, undertake rinsing, 1 / D, with oxygen fluorine to lotion Sha Xing adds loose diluent of rice of ground a place of strategic importance, pressurization rinses 3~4 second, invalid still, undertake probing of groovy tear path is operated.

我科自2000年1月至2006年12月，共治疗新生儿泪囊炎178例、230眼，疗效满足，报告分析如下。1资料和方法1.1一般资料新生儿泪囊炎患儿168例、230眼，男102例，女66例，年龄：2d~3个月，均为本院眼科门诊确诊的新生儿泪囊炎患儿。1.2治疗方法小于1个月的首次就治患儿采用按摩滴药法，治疗1~2周，每日滴药前按摩2~3min，大于1个月的患儿，如滴药治疗1~2周未见明显好转仍有流泪及分泌物者，应用药物加压冲洗泪道，采用自制不同型号尼龙管头皮静脉针头磨钝，制成直的冲洗针，常规操作，针头插入泪小管后，将尼龙管用胶布固定于头部，进行冲洗，1次/d，冲洗液用氧氟沙星加地塞米松稀释液，加压冲洗3~4次，仍然无效的，进行常规泪道探通术操作。1.3治疗标准无流泪、无分泌物、泪道冲洗畅通，反之则无效，结果168例，230眼，治愈166例，228眼，其中按摩治疗49例，冲洗86眼，探通31眼。。。

Methods and Results 194 cases of genual osteoarthritis were randomly divided into tuina group, plaster compress group and combined group, The general effective rate of the tuina group is 80.00%, the plaster compress group is 81.25%; and that of the combined group is 88.54%, but the Control group is 80.56%.

方法与结果采用随机分组方法，将194例骨性膝关节炎患者分为观察组、推拿组和药敷组，研究结果表明：推拿结合药敷治疗组治疗的总有效率为88.54%，单纯推拿治疗组的总有效率为80.00%，药敷组的总有效率为81.25%。

This was the first homeopathic remedy I ever used.

这是我第一次使用顺式治疗药。

The contents of mineral elements, like Fe, in LMTCMs were higher than that of nor-LMTCM. The result of analysis of mineral element of 14 LMTCMs by ICP-MS method also showed the content of Fe have something to do with lung meridian tropism effects. The result of the study of platycodon radix approved the laws too. These laws were used to predict if the marine medicines have the lung meridian tropism effects.2. The Compatibility laws of Medicines and their chemical composition in LSP were studied by mining the data of the constituent herbs and their chemical composition. The results showed that the most constituent medicines of lung system prescriptions have lung meridian tropism. Radix glycyrrhizae, herba ephedrae, semen armeniacae amarum, fructus schisandrae Chinese and their compatibility are common in lung system prescriptions. Terpene, alkaloid, steroid, and flavanoid compounds and their compatibility are common in lung system prescriptions.3. The marine phycophyta medicines of LSP were studied by the same method.

对比归肺经中药及肺系方剂主要化学成分构成，萜类、生物碱、甾体类成分可能是归肺经中药及肺系方剂的主要药效成分；结合君臣佐使药的化学成分构成特点及肺系方剂组成中药的归经构成情况，肺系方剂组方设计应该考虑以下几个方面：一、优先考虑归肺经中药，在应用不归肺经中药时要配伍归肺经中药；二、组方时应考虑含萜类、甾体及生物碱类化合物的中药；治疗肺咳病及咳嗽症状时可以考虑含萜类化合物的中药，治疗气喘症状时可以考虑含生物碱类化合物的中药；三、在确定组方中药或化学成分配伍关系时，君药多考虑含生物碱、黄酮类化合物的中药；臣药、佐药可以考虑含萜类及甾体类化合物中药；使药可以考虑含萜类、甾体类及黄酮类化合物的中药。

Results For single treatment groups,serum drug concentration of chlorpromazine and clozapine were related to age of patients (P＜0 05),concentration of clozapine was related to dosage (P=0 01).For combination group,concentration of chlorpromazine was related to dosage (P＜0 01),also related to scores of PANSS and general psychopathological symptoms (P=0 01),concentration of clozapine was related to scores of PANSS,negative and general psychopathological symptoms (P＜0 05).Multiple linear regression analysis showed that forms and methods of treatment affected concentration of chlorpromazine,age of patients and methods of treatment affected concentration of clozapine.

结果 单用氯丙嗪和采用氯氮平组的血药浓度均与年龄相关（P＜0 05），氯氮平血药浓度与剂量线性正相关（P=0 01）；在双氯组中的氯丙嗪血药浓度与剂量线性正相关（P＜0 01），与PANSS总分及一般精神病理分相关（P=0 01），而氯氮平血药浓度与PANSS总分、阴性量表分及一般精神病理分明显相关（P＜0 05）；多元回归分析显示，治疗形式和治疗方法影响氯丙嗪血药浓度，年龄和治疗方法影响氯氮平血药浓度。

Antihistamines can also minimize itch, but be sure you stick to oral medications.

抗组胺剂也能减少瘙痒，但是你采用的一定要是口服治疗药。

Japan's current treatment of influenza drug Relenza in addition, there are more widely used Tamiflu and so on, are taking unusual actions were reported.

日本目前流感治疗药除RELENZA之外，还有更受广泛使用的克流感等，都有服用者出现异常行动的报告。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。