治疗药

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

The combined acupuncture and medicine group were treated with acupuncture balance points "Jiangya" and "Shenbing" as main, combined with small dose of hypotensor, Irbesartan; and the medication group were treated with oral administration of Irbesartan and Fosinopril.

针药结合组采用针刺平衡&降压穴&和&肾病穴&为主，配合小剂量降压药伊贝沙坦；药物组采用口服伊贝沙坦、福辛普利治疗。

Group B received the treatment of removing fluids from the pericardial cavity with pericardiocentesis intermittently and intrapericardial injection.

将76例结核性渗出性心包炎患者随机分为A组和B组，均予以全身规则抗结核治疗。A组留置中心静脉导管引流及心包腔内注药，B组常规心包穿刺抽液及心包腔内注药。

Conclusions1. To use the corresponding scheme of producing medicine serum for different chinese traditional medicine.2. Liu-Shen-Wan medicine-serum can induce apoptosis of HL-60 cell. It is one of mechanisms in treating leucemia by Liu-Shen-Wan.

1 中药血清药理学含药血清的制备应区分不同的中药，采用相应的方案。2 六神丸含药血清能诱导细胞凋亡，这可能是六神丸治疗白血病的机制之一。

The purpose of this research is to discuss the probable mechanism of acupuncture treatment combined with pharmacotherapy regulating glutamatergic function and anti-free radical effect on the dementia rats due to hippocampal CA, lesions induced by quinolinic acid. So that the author can provide the clinical application of acupuncture treatment combined with pharmacotherapy with experimental evidences in treating Alzheimers disease.

本文的研究目的是探讨针药结合对喹啉酸(Quinolinic Acid，QA)损毁海马CA_1区所致痴呆大鼠模型的中枢兴奋性神经递质谷氨酸(glutamate，Glu)和抗氧化指标的影响及其对提高痴呆大鼠学习记忆能力的可能机理，为临床针药结合治疗阿尔茨海默氏病(Alzheimers disease，AD)提供实验依据。

"Antibiotics can be effective, but inadequate therapy may leave spirochetes alive in the brain, and they may reinvade the bloodstream."

青霉素及其它抗生素治疗有效。若用量不足则停药后每可再发，可能螺旋体潜匿脑中，药物浓度在该处不足以杀灭之，停药后即侵入血流，引致再发。

The bronchial asthmatic model was established by egg protein sensibilization and longterm inhalation provocation.The rats of each treatment groups were lavaged each day from the first time of provocation to execution.After 4 weeks of treatment,the rats were killed to obtain lung tissue for dyeing of HE.A computer assisted image analysis system was used to determine the thickness change of bronchus wall and smooth muscle.The contents of MMP9 and TIMP1 in lung tissue were determined by ELISA double antibody sandwich method.

除正常组外以卵蛋白致敏并吸入激发法制备大鼠支气管哮喘模型，各治疗组均从第1次哮喘激发开始(造模第3周)至处死前每天灌胃给药，激发并给药4 w后处死大鼠，取肺组织HE染色，彩色图像分析仪测量支气管管壁厚度、平滑肌厚度，采用ELISA双抗体夹心法测定肺组织MMP9、TIMP1含量。

We separately poured medicine into their stomaches with BF and CERA by contrasting with two groups of normal and model once a day.

预防给药实验组在末次灌胃后1h以0.2%CCl4 0.2ml腹腔注射制作小鼠实验性肝损伤模型，治疗给药实验组在首次灌胃后1h以0.2%CCl4 0.2ml腹腔注射制作模型。

It is useful to understand the relationship between the structures and functions of the ABC transporters and drug resistance and the prognosis of ovarian cancer patients for individualizing treatment in patients.

了解ABC转运体的结构、功能以及与卵巢癌耐药和患者预后的关系，为卵巢癌患者的个体化治疗提供理论依据，这也成为目前研究卵巢癌耐药机制的热点。

Even for single drugs, the effectiveness of some psychiatric medications in younger patients is questionable: most trials of antidepressants in depressed children, for instance, fail to show any beneficial effect.

甚至一些精神类药物单药对年轻人治疗的有效性都值得怀疑。例如，抗抑郁药在儿童患者中的大部分试验显示均没有任何效果。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。