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The Langendorff model was used, and isolated perfusedrat hearts were separated into untreated, isoflurane, chelerythrine plus isoflurane, and chelerythrine groups.

使用 Langendorff 模型,离体灌注大鼠心脏被分为未治疗组,异氟醚组,白屈菜红碱加异氟醚组和白屈菜红碱组。

Results The CD4(superscript +) 8+ levels in haematoxylin treatment groups was significantly lower than that of models controls. The IgG levels in haematoxylin treatment groups was significantly lower than that of the models group. The level of LSZ was significantly lower than level of model group.

结果 苏木治疗组的CD4/CD8明显低于模型对照组,IgG的含量与模型组比较,12.5 g/kg、25.0 g/kg剂量组明显降低血清IgG水平,LSZ的含量也明显低于模型组,差异有显著性。

Methods: Forty mice were divided into four groups randomly:normal group,model group,ligation group and treatment group.The model was made by the method of partly ligating the recta outside the body.The level of endotoxin in blood plasma was measured by dynamic nephelometric method and the content of TNF-a in blood serum was detected by the method of radioimmunity.(2)After the mice were killed,their left lungs were taken out for bronchi-alveoli fluid, then the content of MDA in BALF was tested by TBA method.(3)The vitality of PAM in BALF was countied on the counting set of erythrocyte,and the blue-dyed cellswere counted, then the percentage of PMN was worked out.(4)The pathological features of the mice\'s lung tissue were observed with routine and ultramicro pathological mechanism.

①将40只大鼠随机等分为正常组、模型组、解扎组、治疗组,以体外直肠不全结扎法造模,以动态浊度法检测各组大鼠血浆内毒素水平,放射免疫分析法检测各组血清TNF-α含量;②大鼠处死后,取左肺进行支气管肺泡灌洗,以TBA法测定支气管肺泡灌洗液中丙二醛含量、白蛋白含量及肺表面活性物质水平;③在红细胞计数盘上作BALF中肺泡巨噬细胞活力计数,计数兰染的细胞数,求出死亡百分率;在光镜下计数BALF沉渣200个细胞,计算中性粒细胞所占百分比。

The underlying diseases included chronic glomerulonephritis(in 71 patients),nephrosclerosis(in 30),diabetic nephropathy(in 5),polycystic kidney disease(in 3),and miscellaneous or unknown disorders(in 9).The severity of renal insufficiency was classified under two groups according to the base-line creatinine clearance:32 patients had mild insufficiency (Ccr 46~60 ml/min),and 86 had moderate insufficiency (Ccr 30~45 ml/min).

先依次选用倍他乐克、双氢克尿噻、心痛定控制病人血压,待血压及肾功能稳定后,根据Ccr将病人分为轻度CRF组(Ccr 46~60ml/min)和中度CRF组(Ccr 30~45ml/min),每组病人再随机分为治疗组(抑平舒2.5~5.0 mg/qd n=80)和对照组(n=38),所有高血压病人继用上述降压药维持正常血压,随访期6个月。

Guinea pig sensitied by ovalbumin for model made and challenged with substance P were second group,and the last two groups were with steroid treatment and contral. Praxiology markers、 IgE、 histamine and SP were detected .Gene chip of rat were used in observing genes expression change.

再经卵蛋白致敏制作变应性鼻炎豚鼠模型,并按模型组,P物质干预组及类固醇激素治疗组及对照组分为四组,观察行为学指标,血IgE,组胺及SP含量的变化,通过鼠芯片观察基因表达谱及其变化。

The results showed that 105pfu/mLBdSA12 group, neomycin group and the health group had no shift of S. pullorum, one broiler in 103pfu/mL BdSA12 group had S. pullorum"s shift, all broilers of infected and non-cure group had S. pullorum"s shift.

结果发现10~5pfu/mLBdSA12组、抗生素组和健康对照组均无细菌易位,10~3pfu/mL组有1例细菌易位,攻毒不治疗组全部都发生细菌易位。

Methods 88 cases with Uu were divided into the study group(48 cases)treated by human recomb ination Interferon-αembolus combined with farmodoxi and the control group (40 cases) treated by farmodoxi only.

88例宫颈Uu单纯检出者,随机分为人重组干扰素α栓联合强力霉素组和单纯应用强力霉素组,其中治疗组48例,对照组40例,分别观察两组疗效。

Put on weigh t observously (P<0.01).In A group,the plasma glucoses and retin al microvessels area density were remarkably lower but

有极显著性差异(P<0.01);②针刺治组大鼠血糖明显低于单纯DM 组(P<0.01);③与单纯糖尿病组相比,针刺治疗组大鼠视网

P-VEP P1 was recorded under anaesthesia, the latency and amplitude of P-VEP in normal group, strabismic group , therapeutic group were analysed.

麻醉下记录P-VEP,比较正常组,斜视组,治疗Ⅰ组、Ⅱ组P1波振幅和潜时。

The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用,阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制,我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响;以Lewis肺癌自发性转移为模型,考察了托吡酯对肿瘤生长和转移的影响;同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响;检测了其对血管新生的作用;利用体外AQP1表达模型,研究了CA抑制剂对AQP1功能的影响;此外,用蛋白质组学的关键技术,通过对模型组与托吡酯治疗组血清蛋白质组的比较分析,来寻找与肿瘤转移相关的蛋白质,探索托吡酯的可能作用靶点。

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