治疗组

Methods: SHR were randomly divided into atRA treated group,dissolvent treated group and captopril treated group.

18只SHR大鼠随机分为全反式维甲酸治疗组、对照组、卡托普利治疗组，每组6只。

Methods 135 patients were randomly divided into 2 groups:in treatment group women took one intravaginal estriol suppository (contained 2mg estriol) and in control group women took 0 5 gram intravaginal premarin cream (contains 0 3125mg premarin) per day.1 week later,drugs were taken weekly and this last 8 weeks.

方法对 135例老年性阴道炎妇女随机分成两组：90例治疗组每日将含 2mg的雌三醇栓 1枚放入阴道深部，1周后每周放入 1枚，连用 8周；45例对照组用药为含 0 312 5mg倍美力的倍美力软膏，用法同治疗组。

METHODS Seventy-eight patients were divided into three groups; saline control, epidermal growth factor experimental group, and platelet-derived wound healing factor experimental group.

将78例糖尿病患者分为三组，即生理盐水对照组、表皮细胞生长因子治疗组、血小板源伤口愈合因子治疗组。

Estimate the treatment effect of fibrinolysin by comparing the clinical results of these two groups.

126例下肢深静脉血栓患者，分为治疗组（64例）和对照组（62例），治疗组应用纤溶酶静滴，对照组应用低分子右旋糖酐注射液加丹参静滴，通过两组比较，评价纤溶酶的f临床效果。

The pathologic changes were observed by light and electron microscope.Results The liver tissues of the rats in model group showed obvious hydropic and fatty degeneration.And the necrosis foci of hepatocytes were seen in liver tissue.

结果 模型组大鼠的肝组织呈现明显的水样变性和脂肪变性，并可见肝细胞坏死灶，姜黄素治疗组的肝细胞未见坏死改变，水样变性和脂肪变性程度减轻，以高剂量姜黄素组的治疗效果最为明显。

Results The liver tissues of the rats in model group showed obvious hydropic and fatty degeneration.And the necrosis foci of hepatocytes were seen in liver tissue.Hepatocytes in curcumine treatment group showed no necrotic changes,and the degree of hydropic and fatty degeneration was markedly reduced,especially in the high-dose curcumine treatment group.

结果 模型组大鼠的肝组织呈现明显的水样变性和脂肪变性，并可见肝细胞坏死灶，姜黄素治疗组的肝细胞未见坏死改变，水样变性和脂肪变性程度减轻，以高剂量姜黄素组的治疗效果最为明显。

1, case of illness elects from 2004.1 - 2005.3 60 examples headaches which receives a medical examination in the Hubei Province Chinese medicine hospital outpatient service and the hospital ward the Yin deficient positive high compressed-air driven patient, uses stochastic, the parallel comparison method, the treatment group and according to 1: 1 proportion, stochastically divides into nourishes yin invigorates the kidney treats disorders of the liver dives positive Dan to treat the group and Nimmo is even, each group of 30 examples, give the medicine in turn according to the serial number, 30 day is continuously a treatment course, after had finished carries on the curative effect to evaluate.

1、病例均选自2005.1—2006.3在湖北省中医院门诊和病房就诊的60例头痛之肝肾阴虚型病人，采用随机、不设盲的方法，治疗组与对照组按1：1的比例，随机分为滋阴补肾平肝潜阳片治疗组和尼莫地平对照组，每组30例，按序号依次给药，连续用药30天为一个疗程，用药结束后进行疗效评定。

The ovaries were excised in the group A, B, C, and the celiotomy was done in the group D (no-excise ovaries). Twelve weeks after the operation, group A, D were administed stilled water 10ml per kilogram every day; group B were administed extract of Bushen Yigu recipe 10ml per kilogram every day; group C were administed water solution of α-D3 soft gelatin capsule 10 ml per kilogram every day.

取12周龄Wistar雌性大鼠40只，随机分为模型组、治疗组、阳性时照组、正常对照组4组，每组10只。D组行假手术，其余3组行完整双侧卵巢摘除术，术后常规饲养12周。A、D组以蒸馏水10ml/kg灌胃，B组以10ml/kg补肾益骨方提取液灌胃，C组以10ml/kgα-D3胶丸水溶液灌胃。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！