治疗物

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

AIM: To observe whether N-Butyl cyancacrylate as filler is able to prevent the recurrence of physeal bridge after operation, and preliminarily investigate the effect of filler in the partial early-closure treatment on the epiphyseal plate.

目的：观察α-氰基丙烯酸正丁酯作为充填物能否阻止手术后的骨桥复发，并初步探讨充填物在骺板部分早闭治疗中的作用。

The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

此外，本发明提供了药物组合物，其包含所述的异羟肟酸异羟肟酸衍生物，本发明还提供了这些药物组合物的安全的剂量给药方案，其可以容易地遵照，并且其在体内产生该异羟肟酸衍生物的治疗有效量。

In chapter 2 of this dissertation, a highly efficient synthesis of the title compound: 1-methyl-2, 3, 3a, 4, 5, 9b-hexahydro-1H-pyrrolo [3, 2-h] isoquinoline (157), a conformationally constrained nicotine analog, has been accomplished in only seven steps starting from commercially available 3-bromopyridine.

在第二章中，我们对具有刚性构象的尼古丁类似物的合成进行了研究。医学研究表明，尼古丁及其类似物对许多神经系统类疾病具有很好的治疗效果，而且药理活性与分子的构象有着非常密切的关系，许多具有刚性构象的分子有着很强的药理活性。

The medicine composition is used in treating laryngopharyngitis, and has high safety, low cost, high effective component content and high stability.

本发明药物组合物克服了现有药物在药效方面的不足，从而提供一种安全性好、成本低、有效成分含量更高、稳定性更好的一种治疗咽喉炎的药物组合物。

Maxillary sinus puncture was performed on these patients both for sampling of sinus contents and irrigation of the diseased sinuses. Aspirate contents of the sinuses were collected for aerobic and anaerobic cultivation. 3 A prospective study of pediatric patients with community-acquired rhinosinusitis was conducted. Bacterial culture was performed on the specimens obtained from maxillary sinus by puncture and middle meatus by endoscopic sampling. The correlation and diagnostic usefulness of endoscopic middle meatal culture versus maxillary sinus puncture were determined.

我们搜集鼻咽癌放射线治疗后患有急性上颔窦炎的病人，以上颔窦穿刺搜集这些病患的鼻窦分泌物并冲洗其患病的鼻窦，收集到的鼻窦分泌物则送往实验室做细菌培养。3 我们执行前瞻性研究，收集患有社区感染鼻及鼻窦炎的儿童，这些病童会同时接受内视镜中鼻道培养与上颌窦穿刺培养，为了厘清儿童使用内视镜中鼻道培养的可信度，我们计算内视镜中鼻道培养与上颌窦穿刺培养结果的关联性与诊断测试。

For improving cholestasis of liver,the content of TBil reduced obviously,the effects of BIF(8.27±0.38μmol/L) were better than that(8.59±0.27μmol/L) of EAV(2.0g/kg).

在改善肝脏的胆汁瘀滞程度方面，各治疗组TBil含量均明显降低(P＜0.01)，其中鹿茸醇提物2.0g/kg可将TBil降低至8.59±0.27μmol/L，作用效果优于醇提物1.0g/kg，但均低于联苯双酯(8.27±0.38μmol/L)。

This may be explained by follows: First, Decoction Shenkangling can regulate the homeostasis of NEI network and reduce the increased activity of NF-κB to restrain the action of inflammatory-sclerotic media; Second, it can redress the disequilibrium of the ratio of TXA2/PGI2 to reform the hypercoagulable state; Third, it can enhance albumin and reduce cholesterol and triglyceride; Fourth, it can amend the renal damage and protect the function of renal tubule and stroma to prevent the transformation from MCD to FSGS; Last, it can lessen urine protein in AN rats markedly and relieve the side effects of prednisone.4. NF-κB, TXA2 and PGI2, along with the renal pathomorphology and so on can all be the indexes of the diagnosis of Symptom of "Kidney Deficiency and Blood Stasis" and the application of Methods of "Benefiting the kidney and Promoting blood circulation" in TCM.5. The curative effects on AN rats by treatment of integrating Traditional Chinese Medicine with prednisone are much better than using prednisone only. And the curative effects on AN rats by treatment of matching Decoction Shenkangling, having the function of "Benefiting the kidney and Promoting blood circulation", with Prednisone are much better than using Prednisone only.6. When it referred to decreasing urine protein, cholesterol and triglyceride and increasing albumin, Decoction Zhibodihuang excesses Decoction Taohongsiwu. However, when it referred to regulating the disequilibrium of TXA2/PGI2 and meliorating renal lesion, Decoction Taohongsiwu exceeds Decoction Zhibodihuang.7. The curative effects on AN rats by treatment of matching Methods of "Benefiting the kidney and Promoting blood circulation" with Prednisone overmatches using Prednisone matching Method of "Benefiting the kidney" or Method of " Promoting blood circulation" only.

益肾活血中药肾康灵能显著改善AN鼠的肾虚血瘀证的临床表现和实验指标，这可能与中药肾康灵能调理AN鼠机体的NEI网络功能稳态，降低异常升高的NF-κB活性，抑制免疫炎症/硬化介质环节，纠正失衡的TXA2/PGI2，改善AN鼠血液高凝状态，提高AN鼠的血清Alb，降低Ch和TG，减轻AN鼠的肾脏组织病理学变化，保护肾小管－间质功能，阻止MCD向FSGS转化；显著减轻AN鼠的尿蛋白水平以及减轻激素副作用有关。4、NF-κB、 TXB2和6-keto-PGF1α以及肾脏病理形态学改变等，都可作为中医肾虚血瘀证诊断和益肾活血法应用的客观指标。5、中西医结合干预AN鼠疗效优于单纯激素治疗；强的松配合益肾活血中药肾康灵组的综合疗效显著优于单纯强的松组。6、知柏地黄汤组在降低尿蛋白、提高血清Alb、降低Ch和TG疗效上优于桃红四物汤组；桃红四物汤组在纠正失衡的TXA2/PGI2和减轻肾脏病理损害方面优于知柏地黄汤组。7、激素配合益肾活血法干预AN鼠在一定程度上优于激素配合益肾法或活血法。

A Chinese medicine for treating cardiovascular disease is prepared from 7 Chinese-medicinal materials including ginseng, cinnamon bark, musk, borneol, etc through extracting.

本发明属于中药组合物技术领域，具体为一种治疗心血管疾病的中药组合物及其指纹图谱分析方法。

In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y1 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

在另一个实施方案中，本发明公开了包含这种NPY Y1受体拮抗剂的药物组合物以及使用所述组合物治疗肥胖、代谢紊乱、饮食紊乱和糖尿病的方法。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。