治疗物

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用，PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化，从而减少脂质的异位沉积，进一步改善损伤的胰岛素信号转导通路，逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体；脂肪酸代谢；胰岛素抵抗

Stable pharmaceutical compositions containing 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6] cycloheptic [1,2-b] pyridine and a DCL protective amount of a pharmaceutically acceptable basic salt such as calcium dibasic phosphate and an amount of at least one disintegrant, preferably two disintegrates such as microcrystalline cellulose and starch sufficient to provide dissolution of at least about 80% by weight of the pharmaceutical composition in about 45 minutes and suitable for oral administration to treat allergic reactions in mammals such as man are disclosed.

本发明公开了含有8－氯－6，11－二氢－11－（4－亚哌啶基）－5H－苯并［5，6］环庚三烯并［1，2－b］吡啶和DCL保护量的可药用碱性盐如磷酸氢钙以及其含量足以使至少约80％的药物组合物在约45分钟内溶解的至少一种崩解剂、优选两种崩解剂如微晶纤维素和淀粉并且适于口服给药以治疗哺乳动物、例如人的过敏反应的稳定的药物组合物。

The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

本发明进一步包括包含所述融合蛋白的药物组合物，和使用所述融合蛋白和/或所述药物组合物(例如在需要治疗的受试者中刺激红细胞生成)的方法。

Methods The total RNA of leucocyte was extracted 43 allergic vasculitis patients and 24 normal subjects before and after treatment with Trizol reagent and the integrity and concentrations of HLA-DRw53 gene mRNA were determined by agarose gel electrophoresis and UV spectrophotometer after denatured with 1% formaldehyde, the product was transcribed into complementary retroviral synthetic deoxyribonucleic acid, and sequence-specific primers were designed based on the sequences of second HLA-DRw53 gene exon and housekeeping gene glyceraldehyde phosphate-dehydrogenase cDNA.

利用随机引物逆转录合成互补脱氧核糖核酸，根据HLA-DRw53基因第二外显子序列和管家基因人磷酸甘油醛脱氢酶的cDNA序列设计序列特异性引物。检测43例变应性血管炎患者治疗前后与24名正常人HLA-DRw53基因mRNA表达量的变化。

Methods Rabbits were administered by intravaginal amoxicillin and metronidazole solution, then the experimental vaginitis model were established by E. coli and Staphylococcus aureus, were treated with lactobacilli lysates, lactobacilli lysates in lower concentration, lactobacillus fermented broth, the probiotic lactobacillus and N. S for 7 days respectively. The variety in vaginal microecosystem were analysed and investigated.

用阿莫西林和甲硝唑接种家兔建立脱污染模型，再用大肠埃希菌和金黄色葡萄球菌的混合液接种，建立实验性感染模型后，随机分为5组，分别用乳杆菌裂解物原液、裂解物稀释液、发酵上清液、乳杆菌活菌制剂及生理盐水进行治疗，分析和考察阴道菌群变化。

A549 cell line was stimulated with LPS (10 μg/mL) and then treated with Rs504393 (10 μg/mL) for 6 hours. ALI model was established with intranasal administration of LPS (5 mg/kg) in C57BL/6J mice. RS504393 (5 mg/kg) was administered 30 min before LPS dripped nasally. IL-8, IL-1β, plasminogen activator inhibitor-1, monocyte chemoattractant protein-2, and the expressions of CCR1 and CCR2b were studied by using Realtime-RT-PCR, ELISA and cyto-flowmetry.

体外实验选用A549细胞系，应用LPS(10μg/mL)刺激合并RS504393(10μg/mL)治疗6 h后，流式细胞仪技术检测CCR1和CCR2的表达，ELISA法检测细胞培养上清液内白介素-8的浓度；体内实验选用C57BL/6J小鼠，腹腔注射RS504393(5 mg/kg)预处理30 min后经鼻滴入JPS(5 mg/kg)，LPS刺激4 h后收集BALF和肺脏标本，计数BALF内细胞总数，应用BCA法检测BALF内蛋白浓度，Realtime-RT PCR和ELISA法检测BALF和肺脏IL-1β、凝血酶原激活物抑制物-1和单核细胞趋化蛋白-2的表达。

Presented the vulva pruritus secretion to increase the symptom feminine friend should promptly to the regular hospital inspection, in view of causes the vulva vaginitis's cause of disease to carry on the treatment, like the vagina applies medicine, the liquid medicines flushing and the sitz bath, the oral administration sterilization medicine and so on.

已出现外阴瘙痒分泌物增多症状的女性朋友应及时到正规医院检查，针对引起外阴阴道炎的病因进行治疗，如阴道上药、药水冲洗和坐浴、口服消炎药物等。

The vomitus was initially clear but just before ho italization was said to brownish.

最初的呕吐物是透明的，但据说住院治疗之前的呕吐物，带有褐色。

The role of Serum amyloid A,matrix metalloproteinase,creactiveproteinand some other biological mark are regulated by inflammatory or autogenetic inhibition,which in diagnosing and curing ankylosing spondylitis are more and more clear.

血清淀粉样蛋白A、基质金属蛋白酶、C反应蛋白等生物标记物通过炎性因子或其自身抑制物等多种炎性物质调节在机体内的表达，作用机制在诊断和治疗强直性脊柱炎过程中已愈发明晰。

The invention is constituted by raw material drugs which adopt part by weight to be a unit, and the raw material comprises 35 parts of cassia seeds, 30 parts of loranthus parasiticus, 30 parts of haws, 20 parts of lotus plumules, 20 parts of scrophularia roots, 15 parts of wild chrysanthemum flower, 15 parts of seabuckthorn fruit, 10 parts of kudzu roots, and 10 parts of cimicifuga foetida.

本发明公开了一种治疗高血压所致的头痛、眩晕、耳鸣、肢体麻木等症的药物组合物及其制备方法，该药物组合物主要由以重量份为单位的下列原料药组成：决明子35份、桑寄生30份、山楂30份、莲子心20份、玄参20份、野菊花15份、沙棘15份、葛根10份和升麻10份。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。