治疗地

SEC. 213. Subject to the conditions of this section and tosuch terms and conditions as the Administrator determines to benecessary to carry out the purposes of this title, the Administratoris authorized to guarantee, and to make commitments to guarantee, the principal and interest (including interest accruing between the date of default and the date of the payment in full of the guarantee) of any loan, obligation, or participation therein of any State, municipality, or intermunicipal or interstate agency issued directly and exclusively to the Federal Financing Bank to finance that part of the cost of any grant-eligible project for the construction of publicly owned treatment works not paid for with Federal financial assistance under this title, which project the Administrator has determined to be eligible for such financial assistance under this title, including, but not limited to, projects eligible for reimbursement under section 206 of this title.

a 依于这部分和tosuch 期限和条件的条件作为管理员确定对benecessary 执行这个标题， Administratoris 的目的被批准保证，和做承诺保证，主要和兴趣(包括兴趣累积在缺省日期和付款的日期之间充分保证)任一贷款、义务，或参与在其中任一个状态、自治市，或intermunicipal 或跨境代办处直接地和完全被发布对联邦财务银行提供经费，一部分的任何授予合格的项目的费用为公开地拥有的治疗工作的建筑没被支付与联邦财政协助在这个标题之下，射出管理员确定是有资袼这样的经济援助在这个标题之下，包括，但没限制对，项目有资袼退款在部分206 之下这个标题。

Subject to the conditions of this section and to such terms and conditions as the Administrator determines to be necessary to carry out the purposes of this title, the Administrator is authorized to guarantee, and to make commitments to guarantee, the principal and interest (including interest accruing between the date of default and the date of the payment in full of the guarantee) of any loan, obligation, or participation therein of any State, municipality, or intermunicipal or interstate agency issued directly and exclusively to the Federal Financing Bank to finance that part of the cost of any grant-eligible project for the construction of publicly owned treatment works not paid for with Federal financial assistance under this title, which project the Administrator has determined to be eligible for such financial assistance under this title, including, but not limited to, projects eligible for reimbursement under section 206 of this title. No guarantee, or commitment to make a guarantee, may be made pursuant to this section—(1) unless the Administrator certifies that the issuing body is unable to obtain on reasonable terms sufficient credit to finance its actual needs without such guarantee; and (2) unless the Administrator determines that there is a reasonable assurance or repayment of the loan, obligation, or participation therein. A determination of whether financing is available at reasonable rates shall be made by the Secretary of the Treasury with relationship to the current average yield on outstanding marketable obligations of municipalities of comparable maturity.

依于这个部分的条件和对如此期限和条件象管理员确定是必要执行这个标题的目的，管理员被批准保证，并且做承诺保证，主要和兴趣(包括兴趣累积在缺省日期和付款的日期之间充分保证)的任何贷款，义务，或参与在其中任何状态，自治市，或intermunicipal 或跨境代办处直接地和完全被发布对联邦财务银行提供经费一部分的任何授予合格的项目的费用为公开地拥有的治疗工作的建筑没被支付以联邦经济援助在这个标题之下，哪个项目管理员确定是有资袼这样的经济援助在这个标题之下没有保证，或承诺做保证，可以被做寻求这个部分(1)除非管理员证明发布的身体无法获得在合理的期限充足的信用提供经费给它的实际需要没有这样的保证；并且(2)除非管理员确定有贷款的合理的保证或偿还，义务，或参与在其中。

Methods 45 patients with GO were divided into four groups randomly, group B with anti-thyroid drugs, group C with anti-thyroid drugs and steroids, group D based on group C and additional retrobulbar injection with steroids, group E based on group C and additional intrathyroid injection with steroids.

45例GO分为4组：B组抗甲状腺药物治疗；C组同时口服强的松；D组：C组＋球后注射地塞米松；E组：C组＋甲状腺注射地塞米松和奥曲肽。

The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS.

本结果指明艾地苯醌改善了患者大脑线粒体的氧化代谢，同时並提示艾地苯醌具有治疗MELAS（线粒体脑肌病伴高乳酸血症和卒中样发作）的潜在效应。

Results Microdose combined medication of Captopril and Nitredipine treated hypertension, the total effective rate was 90.9%,Captopril only 63.6%,Nitrendipine only 62.5%.

结果 卡托普利和尼群地平小量联和，治疗高血压病总有效率 90 。9%，单用卡托普利总有效率 63.6%，单用尼群地平总有效率 62 。5%。

The serum NO level during the during the period of attacks of MWA is higherthan that during the intermittent of control group, and this show that NO plays an important role in the during the periord of MWA.

二组比较，电针组降低血清NO的幅度明显优于尼莫地平组（P.05），说明电针疗效优于尼莫地平；其机理可能是电针治疗后，血清NO浓度的降低，从而抑制NO超过一定积蓄而致脑血管异常扩张。

After being taking electro- acupuncture, acupuncture and Nimodipine, the serum SIL- 2R level is significntly lower MWA, and support the view that the abnormal immunity function is involved in a MAW patient.

采用电针、针刺和尼莫地平治疗后，各组患者血清中SIL-2R水平均显著降低。提示SIL-2R参与了偏头痛的病理过程，支持偏头痛患者存在免疫功能异常的观点；电针组与尼莫地平组均能显著降低血清SIL-2R含量（P.01）。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Similarly, patients with persistently uncontrolled BP were more likely to be nonadherent to medications (OR=1.50) and to have had therapy intensified （OR=2.86 than those with normal BP that remained controlled.

简单地说，持续高血压患者多数药物依从性差(OR=1.50)，并且比血压控制正常的患者更多地采取强化治疗的手段。

objective to search the factors of liver injury via the anit-induced liver injury in rats.methods male sprague-dawley rats,were divided into 4 groups,data were analyzed using a completely randmized factorial anova and linear correlation.results after anit intoxication,the necrosis of hepatic cell and neutrophil infiltration im periportal region of the liver were observed in liver setions.jinshisan can reduce the alt,the tbil.pla2 correlated positively with alt、akp and tbil.conclusion the severity of anit-induced liver injury correlated positively with the pla2.jinshisan can protect against the rat anit-induced liver injury.

目的 拟通过对α－萘异硫氰酸酯诱导大鼠肝损伤发病机理的探讨，对引起肝损伤的因素进行系统的研究。方法选择s-d大鼠，雄性，随机分4组，检测数据以平均值±标准差表示，采用方差分析，相关分析进行统计学处理。结果s-d大鼠经anit染毒后，病理切片显示肝损伤明显，汇管区有大量中性粒细胞浸润。经金石散及地塞米松治疗后，生化指标均有所下降，中药金石散优于地塞米松，血生化指标与pla2活性相关分析显示，呈正相关。结论 anit诱导的肝毒性损伤程度与肝组织匀浆pla2活力呈正相关，应用抑制剂降低pla2活力，肝损伤程度也减轻，中药金石散具有降低pla2活性，减轻肝毒性损伤。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！