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Objective: To investigate different therapies and results of acute gouty arthritis of knee joint.

目的:探讨不同治疗方法对急性痛风性膝关节炎的治疗效果。

All patients are prohibited to use any other KOA medicine during treatment period.

治疗期间禁用任何其他治疗骨性关节炎的中西药物。

There were 12 rabbits (24 articular genus) in every group. Osteoarthritis model was established by injection of caroid in articular genu intracavitary. Rabbits with osteoarthritis were interfered by Duhuojisheng decoction. The expression of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis were measured by double antibody sandwich ELISA 1, 3, 5 weeks after treatment.

将24只兔随机分为2组,即对照组和治疗组,各12只,24个膝关节,采用兔膝关节腔内注入木瓜蛋白酶造成骨关节炎的病理模型,以独活寄生汤浓缩液餵食饲养,於治疗后1、3、5 周分别抽取关节液,采用双抗体夹心酶联免疫吸附法,分别测定兔膝关节液中IL-1及TNF 表达水平。

Methods 24 rabbits were randomly divided into control and treatment groups. There were 12 rabbits (24 articular genus) in every group. Osteoarthritis model was established by injection of caroid in articular genu intracavitary. Rabbits with osteoarthritis were interfered by Duhuojisheng decoction.

将24只兔随机分为2组,即对照组和治疗组,各12只,24个膝关节,采用兔膝关节腔内注入木瓜蛋白酶造成骨关节炎的病理模型,以独活寄生汤浓缩液喂食饲养,于治疗后1、3、5 周分别抽取关节液,采用双抗体夹心酶联免疫吸附法,分别测定兔膝关节液中IL-1及TNF 表达水平。

The re were 12 rabbits (24 articular genus) in every group. Osteoarthritis model was established by injection of caroid in articular genu intracavitary. Rabbits with osteoarthritis were interfered by Duhuojisheng decoction. The expression of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis were measured by double antibody sandwich ELISA 1, 3, 5 weeks after treatment.

将24只兔随机分为2组,即对照组和治疗组,各12只,24个膝关节,采用兔膝关节腔内注入木瓜蛋白酶造成骨关节炎的病理模型,以独活寄生汤浓缩液喂食饲养,于治疗后1、3、5 周分别抽取关节液,采用双抗体夹心酶联免疫吸附法,分别测定兔膝关节液中IL-1及TNF 表达水平。

There were 12 rabbits (24 articular genus) in every group. Osteoarthritis model was established by injection of caroid in articular genu intracavitary. Rabbits with osteoarthritis were interfered by Duhuojisheng decoction. The expression of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis were measured by double antibody sandwich ELISA 1, 3, 5 weeks after treatment.

将24只兔随机分为2组,即对照组和治疗组,各12只,24个膝关节,采用兔膝关节腔内注入木瓜蛋白酶造成骨关节炎的病理模型,以独活寄生汤浓缩液喂食饲养,于治疗后1、3、5 周分别抽取关节液,采用双抗体夹心酶联免疫吸附法,分别测定兔膝关节液中IL-1及TNF 表达水平。

Osteoarthritis model was established by injection of caroid in articular genu intracavitary. Rabbits with osteoarthritis were interfered by Duhuojisheng decoction. The expression of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis were measured by double antibody sandwich ELISA 1, 3, 5 weeks after treatment.

将24只兔随机分为2组,即对照组和治疗组,各12只,24个膝关节,采用兔膝关节腔内注入木瓜蛋白酶造成骨关节炎的病理模型,以独活寄生汤浓缩液喂食饲养,于治疗后1、3、5 周分别抽取关节液,采用双抗体夹心酶联免疫吸附法,分别测定兔膝关节液中IL-1及TNF 表达水平。

Methods and Results 194 cases of genual osteoarthritis were randomly divided into tuina group, plaster compress group and combined group, The general effective rate of the tuina group is 80.00%, the plaster compress group is 81.25%; and that of the combined group is 88.54%, but the Control group is 80.56%.

方法与结果采用随机分组方法,将194例骨性膝关节炎患者分为观察组、推拿组和药敷组,研究结果表明:推拿结合药敷治疗组治疗的总有效率为88.54%,单纯推拿治疗组的总有效率为80.00%,药敷组的总有效率为81.25%。

Objective: In order to observe the long-term effect of high tibial osteotomy in treating the medial compartment osteoarthrosis of the knee.

目的 :为了观察胫骨高位截骨术治疗膝关节骨关节炎的远期治疗效果。

It is evidents that "Wenjing" a mixture shows certain inhibitory effect on the production of TNF-α and IL-1β in synovial cells, which may be one of the mechanism of the therapeutic effect on rheumatoid arthritis.

提示问荆合剂对Ⅱ型胶原诱导的大鼠关节炎具有一定抑制作用,可通过抑制关节滑膜分泌的炎性细胞原子TNF-α、IL-β的水平,从而减轻关节滑膜的炎症,可能是其治疗类风湿关节炎的作用机制之一。

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