没有降低的

A dose-dependent inhibition of cGMP-PDE activity was observed when cUMP 10~(-6-10~(12) M was added to the culture medium, which may explain the increase of the level of intracellular cGMP, while the activity of cAMP...

浓度为10~(-6)-10~(-12)McUMP对胞内cAMP-PDE活性几乎没有影响，而抑制cGMP-PDE的活性，抑制作用随cUMP浓度降低而减小，这可能是胞内cGMP水平增高的原因。cUMP可能与细胞的cAMP PK结合，释放催化亚单位，细胞生长的抑制可由此发生。

They were unaware of the extrarenal and renal factors separate from GFR that might influence BUN and reported that serum creatinine concentration was not a reliable indicator of kidney damage.22 Morris subsequently developed, produced, and sold a reduced-protein diet, KD, for dogs with renal failure.

没有被注意到的肾外和肾脏因素被肾丝球体过滤率做分离，其有可能影响血中尿素氮，报告也指出血清肌酸酐浓度并不是一个可靠测量肾脏损害的指标。22 Morris随后为了肾衰竭的狗开发出降低蛋白质的饮食、进而生产、分装做销售。

That is, generally, they are not suffering from organic or functional diseases and disability, but feel discomfortable, fatigue, blunt, inactive or inadaptable, and are always in a state of anxiety, annoyance, fastidium or hopelessness, and are very tired with life.

通俗地说，就是这70％的人通常没有器官、组织、功能上的病症和缺陷，但是自我感觉不适，疲劳乏力，反应迟钝、活力降低、适应力下降，经常处在焦虑、烦乱、无聊、无助的状态中，自觉活得很累。

That is, generally, they are not suffering from organic or functional diseases and disability, but feel discomfortable, fatigue, blunt, inactive or inadaptable, and are always in a state of anxiety, a oyance, fastidium or hopele e , and are very tired with life.

通俗地说，就是这70％的人通常没有器官、组织、功能上的病症和缺陷，但是自我感觉不适，疲劳乏力，反应迟钝、活力降低、适应力下降，经常处在焦虑、烦乱、无聊、无助的状态中，自觉活得很累。

The α-methylenecyclopentanone, as an isostere of α-methylene-γ-lactone, within the molecules of diterpenes may be as effective as α-methylene-γ-lactone towards various sulfhydry-containing enzymes.

然而，由于α-亚甲基-γ-丁内酯结构内在的化学活性太强，尽管这些合成的小分子化合物仍具有抗癌或抗炎活性，但并没有达到降低毒性，提高选择性的目的。

Along with seawater stress strength upward, the ratio of root to shoot, Na+, Cl- and soluble sugar contents were increased significantly. Under the 10% and 20% seawater treatments, chlorophyll contents have no obvious difference compared with the control, but significantly decreased when the seawater stress further increased. Under the 10% seawater treatments, K+ contents in the shoot and root of Lactuca indica seedlings have no distinct difference compared with the control, but along with seawater stress strength upward, K+ content were markedly decreased by degrees. However, soluble protein content first increased then decreased with seawater concentration augment.

结果表明：苦荬菜幼苗地上部受海水胁迫较为显著，而根在30%海水以内与对照相比没有显著差异；根冠比随着海水比例的增加而提高；10%和20%海水处理下，叶绿素含量与对照相比差异不显著，但随着海水浓度的进一步增加，叶绿素含量显著下降；10%海水处理下，苦荬菜地上部分及根K+含量与对照差异不显著，高于10%海水处理，K+含量随海水比例的增加地上部和根部均逐渐显著降低；海水处理下，体内Na+和Cl-含量逐渐显著增加；地上部可溶性糖逐渐显著增加，而可溶性蛋白呈先升后降。

As similar defects are not exhibited by mice that experience systemic inhibition of NF-B, we postulated that the morphogenetic defects in IKK--deficient mice are not caused by reduced NF-B activity but instead are due to failed epidermal differentiation that disrupts proper epidermal–mesodermal interactions.

因为类似的缺陷没有出现在经历了全身NF-B抑制的小鼠，作者推断IKK缺失小鼠的形态发生缺陷不是由于NF-B活性降低引起而是因为可以破裂专属表皮－中胚层相互作用的表皮分化失败引起。

However, the forced expression of exogenous Smad3 did not rescue the inhibition of myogenic differentiation by hypoxia.

在研究过程中，我们发现在低氧抑制成肌细胞体外分化过程中Smad3蛋白的表达水平降低，然而，在C2C12细胞中过表达外源性的Smad3没有能够逆转低氧对成肌细胞分化的抑制作用。

He experiment proved that pre-implantation embryos are more sensitive than post-implantation ones, suggested TCDD may exert its effect before implantation, or at this process. 3. The toxicity of TCDD on the early embryo can be of omnifarious. It can strongly inhibit DCR, which represent mother toxicity; It cause un-synchronizated cleavage of pre-implanted zygote and pre-implanted embryo loss; It also decreases implantation sites in the uterus, and continued to effecting the uterus of pregnant mouse, cause the decreased number of fetus before birth. 4. TCDD exposure changed reproductive hormone level of pregnant mouse.

CDD对胚胎的毒性影响可能是多方面的：强烈抑制子宫蜕膜细胞反应，表现出典型的母体毒性；虽然没有影响胚胎转运速度，但造成着床前胚胎的丢失和发育不同步；早期染毒降低了第9天的胚胎着床数，同时使出生前第18天胚胎成活数继续减少。

But in the mixture of DSB/AOT, with the increase of DSB, the oxidation rate of pyrogallic decreases gradually to the minimum at the ratio of 7/3, which is only 50% of that in bulk solution.

但是DSB和AOT溶液在混合以后，出现了异常的变化，随着DSB比例的增加，邻苯三酚自氧化速率不但没有上升，反而逐渐降低，在DSB/AOT为7/3时达到最低点，自氧化速率仅为水溶液的50％左右。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新