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An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a is ofIgG1 isotype, b shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum when compared to such an assay without said antibody, and d shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 M in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum when compared to such an assay without said antibody has improved properties in antitumor therapy.

一种已经提高了抗肿瘤治疗的特性的抗体,所述抗体结合IGF-IR并且抑制IGF-I和IGF-II与IGF-IR结合,其特征在于所述抗体a是IgG1同种型,b显示其对IGF-I与IGF-IR结合的抑制的IC 50 值与其对IGF-II与IGF-IR结合的抑制的IC 50 值的比率为1∶3-3∶1,c当与没有所述抗体的这种测定比较时,其在5nM的浓度上,在包含0.5%的热灭活胎牛血清的培养基中,使用3T3细胞的细胞磷酸化测定中,抑制至少80%的IGF-IR磷酸化,所述3T3细胞提供400,000-600,000分子IGF-IR/细胞,和d当与没有所述抗体的这种测定相比,在包含0.5%的热灭活胎牛血清的培养基中,使用3T3的细胞磷酸化测定中,其在10μM的浓度上没有显示作为IGF-IR磷酸化所测量的IGF-IR刺激活性,所述3T3提供400,000-600,000分子IGF-IR/细胞。

Yes, I suppose it is a no brainer but pretty soon it will be a "no arrmer" [3] and a "no legger".

是, 我假设这是没有brainer 但这相当很快将是&没有arrmer& sic 并且&没有legger&。

The effects of many factors in the wet end on drainage and retention of PEO/attapulgite system: During the scope of 2-12, pH has no effect on drainage, and retention ratio lower in acidic conditions and higher in neutral or alkaline conditions. There were some improvement on slurry's drainage and some impairment on retention efficiency for the existence of inorganic salts. Lignosulphonate had no effect on drainage and made retention ratio decrease 5-8%; lignosulphonate and xylan had no effect on drainage and made retention ratio decrease a little. 5 .Attapulgite could be modified by intercalation.

纸机湿部系统的影响因素对PEO/凹凸棒粘土助留体系的助留助滤效果的影响表现为:pH值在2-12范围内,对助滤效果是没有影响的,使助留效果在酸性条件下较差,而在中碱性条件下较好;无机盐的存在使浆料的滤水性能有一定的改善,使助留效果有所削弱;木质素磺酸盐对助滤效果是没有影响的,使留着率下降了5—8%;木质素磺酸盐与聚木糖对助滤效果也是没有影响的,使留着率略有下降。

Still it was a sepulchre, unprophetic, voiceless, lusterless.

但仍只见一个没有预兆,没有声音,没有光彩的坟墓。

There are many points of agreement between Mark Medish and me: that Brand America once shone brightly around the world; that America can recover from its current travails and that Americans believe that Brand America can shine again.

没有切合实际情况进行描述,尤其如何处理医疗经济军事和外交等人们关注的问题也没有给出明确的答案,文章将要结尾时才提到了 change ,但是却没有解释如何改变和从哪改变。

She take my money Now I aint sayin she a gold digger (When I'm Need) But she aint messin wit no broke Now I aint sayin she a gold digger (When I'm need) but she aint messin wit no broke get down girl go head get down get down girl go head get down get down girl go head get down get down girl go head [Verse 2:] 18 years, 18 years She got one of yo kids got you for 18 years I know somebody payin child support for one of his kids His baby momma's car and crib is bigger than his You will see him on TV Any Given Sunday Win the Superbowl and drive off in a Hyundai She was spose to buy ya shorty TYCO with ya money She went to the doctor got lypo with ya money She walkin around lookin like Micheal with ya money Should of got that insured GEICO for ya moneeey If you aint no punk holla We Want Prenup WE WANT PRENUP!

合唱团:我现在是不是sayin她一条金挖掘机但她不是messin束手无策,没有发生我现在是不是sayin她一条金挖掘机但她不是messin束手无策,没有发生趴下去的女孩头部着手趴下去的女孩头部着手趴下去的女孩头部着手趴下去的女孩头部 [诗2: ] 18岁, 18岁她摇摇之一,孩子们得到你18年我知道有人payin儿童的支持,他的一个孩子他的孩子momma的汽车和婴儿床大于他的你会看到他在电视上任何特定星期日赢得超级杯和驱动器关闭在一个现代她spose购买亚shorty泰科与亚钱她到医生得到lypo与亚钱她walkin周围查找一样,迈克尔与亚钱应该指出,被保险人得到Geico今年为亚moneeey 如果您是不是没有朋克holla我们希望prenup 我们希望prenup !

It's that rich and multihued vision of a world where no one goes hungry because everyone is invited to a seat at the groaning board, it's a vision of a world where no one is sick or in prison because all sorts of disease have been healed, it's a vision of a world where every human being has the capacity to use every good gift that God has given, it is a vision of a world where no one enjoys abundance at the expense of another, it's a vision of a world where all enjoy Sabbath rest in the conscious presence of God.

它的视野,丰富multihued世界上没有人是因为大家都饿应邀议席的呻吟局它憧憬一个世界里,没有人生病或因各种疾病在狱中已痊愈,它憧憬一个世界上每个人都有能力使用一切好的礼物上帝赐给,这是一个理想的世界里,没有人以牺牲另享丰、它憧憬一个在世界上都享有休息安息日上帝存在的自觉。

If a woman is not sexy, she needs e motion; if she is not emotional, sh e needs reason; if she is not reaso nable, she has to know herself clea rly. coz only she has is misfortune .

女人如果不性感,就要感性;如果没有感性,就要理性;如果没有理性,就要有自知之明;如果连这个都没有了,她只有不幸。

Michael was killed by neglection of the staff who was there and didn't move a single finger to stop all of this garbage, by his family who didn't care of him enough nor wondering to see his real conditions as Liz Taylor did in 1993, by the silent people who witnessed all of this and pretended he was a robot and an ATM machine, by criminal doctors who plagiarized him, telling him that Propofol was the only means of fighting insomnia, instead of treating him seriously with other normal drugs as millions of people in the world are treated!

迈克尔是被在场的工作人员的疏忽杀死的,他们没有做出一点行动来阻止所有那些混账事情;是被他的家人杀死的,他们既没有给与他足够的关心,也没有像 1993年Liz Taylor那样去关心他真正的状况:是被周围的人的漠视杀死的,他们目睹了所有那一切,却假装他是个机器人以及一个自动提款机;是被那些有罪的医生杀死的,他们压榨他,告诉他异丙酚是唯一可以对抗失眠的良药,而不是用其他正常的药物认真治疗他(就像世界上成千上万人被治疗的那样!

Evaluation Information does not include, however, information that is or becomes generally available to the public other than as a result of a disclosure by Buyer or its Representatives, was available to Buyer on a nonconfidential basis prior to its disclosure by Seller or its Representatives, becomes available to Buyer on a nonconfidential basis from a person, other than Seller or its Representatives, who is not known by Buyer to be otherwise bound by a confidentiality agreement with Seller or to be otherwise under an obligation to Seller not to transmit the information to Buyer, or was independently developed by Buyer without reference to the Evaluation Information.

评估信息不包括,然而,信息供给或变得一般公众除由于透露之外由买家或它的代表,供给买家根据一个没有争议的事物。依据在它的透露之前由卖家或它的代表,变得可利用对买家根据一个没有争议的事物。依据从人,除卖主之外或它的代表,由卖家不知道由一个机密协议否则一定以卖主或有义务否则对卖主不传送信息给买家,或由买家独立地开发了没有在评估信息的参考。

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Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车,和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特,那个是爱朗。

Articulate the aims, objectives and key aspects of a strategic business plan.

明确的宗旨,目标和重点战略业务计划。