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沙芬

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We employed HPLC to measure the metabolites of caffeine in the whole blood and calculated the ratio be between the metabolite and caffeine, which was used as index to evaluate the effect of Qingkailing injection on rat CYP1A2 activity in vivo ; We also detected the CYP1A2 and CYP2D6 activity in microsomal reconstituted system by analysis of phenacetin metabolism and dextromethorphan metabolism with HPLC.

通过HPLC法测定全血中咖啡因的代谢率,观测清开灵注射液对大鼠CYP1A2活性的影响;通过HPLC法测定大鼠肝微粒体重组系统非那西丁的代谢比率,确定清开灵注射液对大鼠肝微粒体CYP1A2亚型的作用;测定大鼠肝微粒体重组系统右美沙芬的代谢比率,确定清开灵注射液对大鼠肝微粒体CYP2D6亚型的作用。

My first drug was Dextromethorphan , a psychedelic chemical , typically recognized as a between on soft and hard drugs .

我的第一个药物右美沙芬,迷幻,化学产品,通常公认的作为一个对之间的软,硬的药物。

Owing to their semblable structure,the condition of the chromatography approach which is in common use is demanding and time-consuming.

右美沙芬广泛应用于镇咳药和感冒药,去甲右美沙芬是它的代谢产物。

Methods Seven probe drugs were incubated with or without methyl protodioscin respectively in human microsomes. The specific substrates used in this study were caffeine (CYP1A2), dextromethorphan (CYP2D6), tolbutamide (CYP2C9),-mephenytoin (CYP2C19), chlorzoxazone (CYP2E1), coumarin (CYP2A6) and midazolam (CYP3A4). The concentrations of the substrate metabolites (paraxanthine, dextrorphan, 4-hydroxytolbutamide, 4-hydroxymephenytoin, 6-hydroxychlor-zoxazone, 7-hydroxycoumarin and 1-hydroxymidazolam) were determined by HPLC and LC-MS/MS. Results MPD 1-10 μmolL^(-1 had no significant inhibition on the activities of the seven cytochrome P450 enzymes.

将MPD和CYP450酶7种亚型的特异性探针底物咖啡因(CYP1A2)、右美沙芬(CYP2D6)、甲苯磺丁脲(CYP2C9)、s-美芬妥因(CYP2C19)、氯唑沙宗(CYP2E1)、香豆素(CYP2A6)及咪达唑仑(CYP3A4)与人肝微粒体进行孵化反应,采用HPLC和LC-MS/MS法测定对应的7种代谢产物(1,7-二甲基黄嘌呤、去甲右美沙芬、4-羟基甲苯磺丁脲、4-羟基美芬妥因、6-羟基氯唑沙宗、7-羟基香豆素和1-羟基咪达唑仑)的浓度,通过与对照组比较,确定MPD对以上7种酶活性的影响。

OBJECTIVE:To study the toxicological and pharmacological actions of Yumasha-fen and its gradients.

目的:观察愈麻沙芬及其组份的毒理和药理作用。

But, their side effects limit their clinical uses. Dextromethorphan , a widely used antitussive medicine, is a noncompetitive NMDA antagonist and has been proved to prevent neuronal death induced by focal or global cerebral ischemia with minimal dysphoric and psychotomimetic activities.

右美沙芬(Dextromethorphan,DM)是NMDA受体的非竞争性拮抗剂,同时作为一种中枢镇咳药已广泛用于临床,我室以往的研究发现,右美沙芬在局灶性脑缺血中对神经元具有保护作用,而且没有自身的神经和精神毒性作用。

Objective To study the concentration of dextromethorphan hydrobromide in human plasma.

目的 研究氢溴酸右美沙芬在健康志愿者体内的血药浓度。

The method is accurate and precise,it is usable for the study of clinical dextromethorphan hydrobromide pharmacokinetics.??

本法精密,准确,可用于氢溴酸右美沙芬的药动学研究。??

ABSTRACT OBJECTIVE:To determine the contents of dextromethorphan hydrobromide and ibuprofen in compoud capsule.

目的:测定复方美沙芬布洛芬含量。

RESULTS:The linear ranges of dextromethorphan hydrobromide and ibuprofen were 3.07~15.35μg/ml,39.88~199.40μg/ml,and their mean recoveries were 98.2% and 98.7% with RSD in the range of 0.4%~0.7%.

结果:美沙芬在3.07~15.35 μg/ml,布洛芬在39.88~199.40μg/ml范围内呈线性关系,其平均回收率分别为98.2%和98。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

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