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Between P14 and P21,CIAPIN1 immunoreaction in the brain,heart and liverbecame much lower. However,between P21 and P28,CIAPIN1 immunoreactionin the heart,brain,liver and skeletal muscle became much lower,while with thekidney development,CIAPIN1 immunoreaction in the kidney became higher. Invarious tissues from adult mouse,CIAPIN1 immunoreaction could be seen incardiac muscle cell,brain,hepatocyte,epithelium of renal tubule,skeletal muscle,lung tissue,gastric mucosa and gland,acinus lienalis.2. Distribution of CIAPIN1 in normal fetal and adult human tissuesTo reveal the possible physiological role of CIAPIN1,we examined theexpression and distribution of CIAPIN1 in fetal and adult human tissues usingimmunohistochemistry. We found that CIAPIN1 was ubiquitously distributed infetal and adult tissues,and was localized in both the cytoplasm and the nucleus.

然而,在3个月大的成年鼠中,CIAPIN1阳性反应物在心、脑、肝和肾小管中的表达强度要低于P28小鼠;但CIAPIN1阳性反应物在成年鼠骨骼肌中较P28小鼠高。2、CIAPIN1蛋白在人5个月胚胎及成人多器官组织内的表达在人5月胚胎多器官组织中,CIAPIN1阳性反应物见于心脏、胆囊单层柱状上皮和粘膜、结肠粘膜、小肠粘膜和绒毛、肝脏、直肠腺体、胃粘膜、肾上腺束状带、甲状腺滤泡、脾索、胸腺小叶间隔、皮肤真皮层和汗腺、睾丸白膜和间质、脑组织内神经元和神经胶质、肺小支气管和肺泡、骨骼肌、肾脏皮髓质和肾小管、子宫内膜、胰腺腺泡和胰岛、卵巢、输卵管粘膜等绝大多数组织细胞。

Current treatments range from aluminum chloride compounds to surgical removal of sweat glands and sympathectomy.

目前的治疗方法多样,可采用氯化铝治疗,也可手术切除汗腺及阻断交感神经。

XLHED is the most common type of anhidrotic/hypohidrotic ectodermal dysplasia and accounts for 95%of clinical EDA cases.

XLHED的典型临床表现为毛发、牙齿及汗腺发育不良三联征。

CA II and AQP5 expression levels were determined by immunofluorescence and immunoblotting, while CA activity and Na, K-ATPase activity by a colorimetric assay. Anhidrotic mice treated by topiramate did not differ from controls in average secretory coil diameter, CA II expression, CA activity and Na, K-ATPase activity.

应用免疫荧光和western blot技术发现:小鼠在托吡酯处理后泌汗减少,碳酸酐酶同功酶II型(carbonic anhydraseII,CAII)蛋白表达未出现显著变化,但汗腺组织胞膜的水通道蛋白-5(aquaporin-5,AQP5)表达量下调。

Immunofluorescence confirmed that sweat glands in normal mice did not present gamma-aminobutyric acid receptor subtype GABAA andα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainic acid subtype of glutamate receptor. Mature mice with reactive sweat glands that declined more than 25% compared to baseline were defined as anhidrotic mice.

免疫组织荧光染色未发现在正常小鼠皮肤组织及汗腺的分泌细胞存在γ-氨基丁酸A型(gamma-aminobutyric acid,GABAA)受体α1亚单位、谷氨酸受体亚型α-氨基羟甲基恶唑丙酸(α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid , AMPA )GluR1/2/3/4亚单位和海人酸(kainic acid,KA)受体GluR5/6/7亚单位的表达。

Morphologic Diversity of Malignant Neoplasms Arising in Preexisting Spiradenoma, Cylindroma, and Spiradenocylindroma Based on the Study of 24 Cases, Sporadic or Occurring in the Setting of Brooke-Spiegler Syndrome

汗腺瘤、圆柱瘤和汗腺圆柱瘤进展而来的恶性肿瘤的形态具多样性,基于对24例肿瘤散发或以Brooke-Spiegler综合症为基础病变的患者的研究

Methods 55 patients with axillary osmidrosis were treated, firstly apocrine glands were excised by subcutaneous pruning, and then other apocrine glands in the deep of dermis were demolished by CO2 laser vaporization.

对55例腋臭患者实施皱襞切口剪除皮下大汗腺,同时用CO2激光汽化凝固位于真皮深层的大汗腺

Eccrine and apocrine glands and ducts and pilosebaceous units constitute the skin adnexa.

皮肤附属器包括小汗腺、顶泌汗腺及其导管和毛囊皮脂腺单位。

Syringoid eccrine carcinoma is a rare cutaneous malignant tumor thought to be derived from eccrine sweat apparatus.

汗管状汗腺癌是一种目前认为从汗腺延伸而来的罕见皮肤恶性肿瘤。

EA which is rare, malignant and high in incidence of metastasis belongs to a relative histopathologically well-differentiated sub-group of eccrine carcinoma.1 It usually presents as a nodular lesion on the head and neck region and is difficult to be differentiated from a visceral neoplasm with cutaneous metastasis.

汗腺癌是罕见的恶性肿瘤,并有很大可能出现转移,属于组织学方面相对分化良好的汗腺癌的亚细分组。它通常表现为在头颈部区域的的小结节,在显像研究时很难与内脏恶性肿瘤的皮肤转移癌相区分。

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