水疱的

Dystrophic epidermolysis bullosa is a group of genetic disease caused by loss-of-function mutations in the type Ⅶ collagen gene. The clinical phenotype is characterized by the blistering and scaring of the skin from trauma and there is increased complication of squamous cell carcinoma, which is the major cause of death in patients with DEB.

营养不良性大疱性表皮松解症是一种由于人体Ⅶ型胶原基因突变或缺失所引起的遗传性疾病，临床特征为创伤诱发的水疱和瘢痕，并发症以恶性鳞状细胞癌多见，是导致患者死亡的主要因素，目前仍无有效的治疗方法。

To add to this, a blister on his foot is hampering his build-up and preparation for the game at Modena this weekend.

为了达到目的，但是皮波脚上的一个水疱会影响他的发挥，不过他还是努力的备战周末和摩德纳的比赛。

Grouped vesicles on an erythematous base occurring unilaterally are indicative of herpes zoster. It is a common early or initial manifestation of HIV infection.

单侧发生的红斑基底上的群集水疱是带状疱疹的指征，也常是 HIV 感染的早期表现。

Feb. 4, 2002 -- People with bullous pemphigoid no longer need to endure the potential side effects of oral corticosteroids, based on a French study reported in the Jan. 31 issue of The New England Journal of Medicine .

2002年2月4日──1月31日《The New England Journal of Medicine》杂志上发表的一篇法国的研究报道，患有大水疱性类天疱疮的患者，不必再忍受口服皮质肾上腺类脂醇所可能导致的副作用。

The skin lesions progressed with numerous grouped bullae, and erosions on a noninflamed base on the palms and soles which resulted in syndactyl deformities and flexion contracture of hands and feet.

皮肤的损害进展成许多的大水疱与手掌、足掌未发炎的糜腐蚀，导致手脚的并指畸形与屈曲挛缩。

"On March 7, 2007, the Chicago Department of Public Health and the University of Chicago Pediatric Infectious Disease Service and Infection Control Program notified of a child with presumed eczema vaccinatum..., a life-threatening complication of vaccinia virus infection," write J. Marcinak, MD, from the University of Chicago Comer Children's Hospital, in Chicago, Illinois, and colleagues."This case highlights the need for clinicians to maintain a high index of suspicion when evaluating recently vaccinated patients and their family members with vesiculopustular rash."

J。 Marcinak医师及研究同仁指出，2007年3月7日，芝加哥市公共卫生部和芝加哥大学小儿科传染病行政部暨传染控制计划单位，向美国疾病管制局通报了一名儿童推测是感染了疫苗性湿疹，一种致命的牛痘病毒感染并发症；此病例突显出，临床医师在评估近期施打疫苗的患者和其长有水疱与脓疱的家人时，应保持高度警觉性之必要性；Marcinak医师服务於伊利诺州芝加哥市芝加哥大学Comer儿童医院。

As an adjuvant for the protein vaccine,PoIFN-αinduced strong inflammatory cytokine production in vivo and the results denoted that IFN-adjuvant and our vaccines could drive the immune response toward Th1 type responses.The data of ELISA suggests that the recombinant protein vaccine synergizes with the IFN-adjuvant to produce endogenous IFN in vivo.

在病毒攻击实验中，所有的对照组动物均出现口蹄疫临床症状；然而佐剂和疫苗联合注射组的动物均得到保护，没有发现病毒血症和口蹄部水疱，对该组的病毒非结构蛋白抗体检测表明，攻毒14天后没有发现病毒在动物体内复制。

Abstract］ Objective For the purpose of scientific evaluation and improvement on unreasonable parameter of viral inactivation,the dynamics curve of time corresponding to effect by given viral inactivation factor treated to blood plasma product were analyzed.Methods Aimed at vesicular stomatitis virus, sindbis virus, human immunodeficiency virus, polioviruses, pseudorabies virus,encephalon-yocarditis virus; validate data of viral inactivated on pasteurization of albumin, human rabies immunoglobulin with pH 4, human immunoglobulin and human hepatitis B immunoglobulin for intravenous injection with pH 4/pasteurization,treatment on human fibrinogen and human coagulation factor Ⅷ with solvent/detergent and vapor heating at 100 ℃30 min were systemic regularized respectively.The mean and standard deviation also coefficient of variation for virus survival titer in different time were stated, dynamics curve of virus inactivation were made and analyzed.

目的 分析血液制品特定灭活因子的时效动力学曲线，科学性地评价与改进不合理的病毒灭活参方法系统性整理针对水疱性口炎病毒、黄热病毒、脊髓灰质炎病毒、伪狂犬病毒、脑心肌炎病毒、人类免疫缺陷病毒，人血白蛋白采用巴氏消毒法，狂犬病人免疫球蛋白采用低pH常温孵放法，静注人免疫球蛋白、静注人乙肝免疫球蛋白采用低pH/巴氏消毒法；人纤维蛋白原、人凝血因子Ⅷ采用有机溶剂/去污剂与干热法灭活病毒的验证资料，统计3批样品取样点的残余病毒滴度均值、标准差与变异系数，制作灭活病毒动力曲线图并进行分析。

Abstract］ objective for the purpose of scientific evaluation and improvement on unreasonable parameter of viral inactivation,the dynamics curve of time corresponding to effect by given viral inactivation factor treated to blood plasma product were analyzed.methods aimed at vesicular stomatitis virus, sindbis virus, human immunodeficiency virus, polioviruses, pseudorabies virus,encephalon-yocarditis virus; validate data of viral inactivated on pasteurization of albumin, human rabies immunoglobulin with ph 4, human immunoglobulin and human hepatitis b immunoglobulin for intravenous injection with ph 4/pasteurization,treatment on human fibrinogen and human coagulation factor ⅷ with solvent/detergent and vapor heating at 100 ℃30 min were systemic regularized respectively.the mean and standard deviation also coefficient of variation for virus survival titer in different time were stated, dynamics curve of virus inactivation were made and analyzed.results human albumin pasteurization inactivated vsv and sindbis virus,hrig low ph inactivated vsv and sindbis virus,hrig low ph inactivated hiv virus,ivig low ph/pasteurization inactivated hiv virus,ivig low ph inactivated hiv virus,hbig low ph/pasteurization inactivated vsv,sindbis and polio virus.conclusion suggestion about improvement on unreasonable parameter and standard of virus inactivation is made,cultivate target virus directly from final product by appropriate cell or method to monitoring viral safety of blood plasma product is advanced.

目的 分析血液制品特定灭活因子的时效动力学曲线，科学性地评价与改进不合理的病毒灭活参数。方法系统性整理针对水疱性口炎病毒、黄热病毒、脊髓灰质炎病毒、伪狂犬病毒、脑心肌炎病毒、人类免疫缺陷病毒，人血白蛋白采用巴氏消毒法，狂犬病人免疫球蛋白采用低ph常温孵放法，静注人免疫球蛋白、静注人乙肝免疫球蛋白采用低ph/巴氏消毒法；人纤维蛋白原、人凝血因子ⅷ采用有机溶剂/去污剂与干热法灭活病毒的验证资料，统计3批样品多个取样点的残余病毒滴度均值、标准差与变异系数，制作灭活病毒动力曲线图并进行分析。结果人血白蛋白巴氏灭活vsv与sindbis病毒，hrig低ph灭活vsv和sindbis病毒，hrig低ph灭活hiv病毒，ivig低ph/巴氏灭活hiv病毒，ivig低ph灭活hiv病毒，hbig低ph/巴氏灭活vsv、sindbis与polio病毒。结论建议改进病毒灭活验证标准与不合理的灭活参数；采用终产品样品通过合适细胞或方法直接培养目标病毒来有效监测血液制品的病毒安全性。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。