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Methods Naloxone was synthesized starting from oxidation of thebaine, followed by hydrogenation, acylation, cyanidation, O-demethylation, hydrolyzation and N-allylation. The alternative method of O-demethylation, methane sulfonic acid/DL-methionine and hydrobromic acid were investigated.

在以蒂巴因为原料,经氧化、氢化、酰化、氰化、去氧甲基、水解、N-烯丙基化得到纳洛酮的合成路线中,分别采用甲磺酸/DL-甲硫氨酸和氢溴酸代替三溴化硼进行去氧甲基化和后续水解反应。

The synthesis of nalbuphine hydrochloride from thebaine as starting material was through following processes:oxidation,high-pressure hydrogenation,acetylation,removing methyl of 3-methoxy,hydrolysis,condensation,reduction and finial salification.

以蒂巴因为起始原料,经氧化、高压氢化、乙酰化、氰化、脱3-位甲氧基的甲基、水解、缩合、还原、成盐,合成了盐酸纳布啡,总收率达18。

Purified water, euphorbia cerifera wax, glyceryl stearate, ammonium acrylates copolymer, butylene glycol, copernica cerifera wax, stearic acid, sucrose acetate isobutyrate, acrylates copolymer, bentonite, tromethamine, hexylene glycol, silk amino acids, cholesterol, glycine, synthetic wax, ethylhexyl glycerin, alanine, PEG-9 dimethicone, nylon-6, lecithin, silica, simethicone, caprylyl glycol, xanthan gum, propylene glycol, isostearic acid, sodium laureth-12 slfate, ceteareth-20, polyvinyl alcohol, sodium chloride, sodium acetate, disodium EDTA, benzyl alcohol, chlorphenesin, phenoxyethanol, methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, may contain /- mica, iron oxides (CI 77491, CI 77492, CI 77499), titanium dioxide (CI 77891), ferric ferrocyanide (CI 77150), ultramarines (CI 77007), blue 1 lake (CI 42090), bronze powder (CI 77400), aluminum powder (CI 77000), bismuth oxychloride (CI 77163), carmine (CI 75740), chromium hydroxide green (CI 77289), chromium oxide greens (CI 77288), yellow 5 lake CI 19140

水,小烛树蜡,硬脂酸甘油酯,丙烯酸铵共聚物,1,3-丁二醇,巴西棕榈蜡,硬脂酸,异丁酸醋酸蔗糖酯,丙烯酸酯共聚物,蒙脱土,二吡喃乙酸乙酯胺,已烯醇,丝氨酸,胆固醇,甘油,合成蜡,异丁基甘油,丙胺酸,PEG-9二甲基硅油,尼龙-6,卵磷酯,硅粉,硅氧烷,癸酰基乙二醇,汉生胶,丙二醇,异硬脂酸,月桂基醚-12硫酸钠,十六十八醇醚-20,聚乙烯醇,氯化钠,醋酸钠,EDTA二钠,苯氧乙醇,氯代苯酚,卞醇,尼泊金甲酯,尼泊金乙酯,尼泊金丙酯,尼泊金丁酯,尼泊金异丁酯,[可能还含有云母,铁黑(CI 77491, CI 77492, CI 77499),钛白粉(CI 77891),氰化亚铁(CI 77150),靛蓝(CI 77007),蓝1号(CI 42090),青铜粉(CI 77400),铝粉(CI 77000),氯氧化铋(CI 77163),洋红色素(CI 75740),氢氧化铬绿(CI 77289),氧化铬绿(CI 77288),黄5号(CI 19140)]文章来自网络,不代表本网站立场,版权归原作者所有,转载请注明出处!

The alternative method of O-demethylation,methane sulfonic acid/DL-methionine and hydrobromic acid were investigated.

方法在以蒂巴因为原料,经氧化、氢化、酰化、氰化、去氧甲基、水解、N-烯丙基化得到纳洛酮的合成路线中,分别采用甲磺酸/DL-甲硫氨酸和氢溴酸代替三溴化硼进行去氧甲基化和后续水解反应。

One is the interstitial water or zeolitic water, it corresponds to the broad absorptive band at around 3498 cm〓 that results from the association of water owing to the H-bonding. 2 The other is the water coordinated to lanthanum, corresponding to the very strong sharp peak at 3607cm〓, The peaks at around 1600cm〓 were assigned to the bending vibrations of water in LaHCF, two sharp peaks were found at 1601cm〓 and 1624cm〓 respectively, which correspond to two bending vibrations of the interstitial water and the coordinated water respectively in the structure of LaHCF.

通过电化学扫描法,得到了一种有电活性的稀土元素化学修饰电极—铁氰化镧修饰电极;并用循环伏安法进行了表征,比较了碱金属离子Li〓,Na〓,K〓,Rb〓,Cs〓和H〓在膜中的通透性,结果表明氢离子能透过铁氰化镧膜而碱金属离子则不能透过铁氰化镧膜;稳定性研究表明,该修饰电极在纯1.0mol/L HCl溶液中扫描,峰电流迅速下降,到第10圈时峰电流几乎为零,而在混合溶液1.0mol/L KCl+0.10mol/L HCl。

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Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书,王祥生,李德昌。安徽省首次发现嗜群血蜱。

Chapter Three: Type classification of DE structure in Sino-Tibetan languages.

第三章汉藏语&的&字结构的类型划分。