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We set up an orthogonal experiment, use diclofenac sodium as drug model, detect the pemeate velocity, lag time, and transit dose accumulated in 24 hours(Q24) as index of drug action of azone, menthol and camphol using together on skin of back of unde rat on the equipment of percutaneous absorption in vitro, evaluate the contribution of transdermal enhancers by Topsis.

在离体透皮吸收装置上,采用正交试验的设计方法研究不同浓度的氮酮、薄荷醇、冰片联用对双氯芬酸钠在离体裸小鼠背部皮肤上的透皮行为,以累积透过量、渗透速率和滞后时间为药效指标,运用Topsis法评价促透效果。

We set up an orthogonal experiment, use diclofenac sodium as drug model, detect the pemeate velocity, lag time, and transit dos e accumulated in 24 hours(Q24) as index of drug action of azone, menthol and camphol using together on skin of back of unde rat on the equipment of percutaneous absorption in vitro, evaluate the contribution of transdermal enhancers by Topsis.

在离体透皮吸收装置上,采用正交试验的设计方法研究不同浓度的氮酮、薄荷醇、冰片联用对双氯芬酸钠在离体裸小鼠背部皮肤上的透皮行为,以累积透过量、渗透速率和滞后时间为药效指标,运用Topsis法评价促透效果。

Observing the effects of DS on acetic acid-induced writhing and increased capillary permeability in mice when it was administered intraperitoneally, the granuloma formation induced by cotton pellet in rat when it was applied locally, and the mucous membrane irritation of DS lozenge.

观察双氯芬酸钠低剂量低浓度腹腔给药对醋酸致小鼠扭体作用及毛细血管通透性增加的影响,局部给药对大鼠棉球肉芽形成的影响,局部长时间接触对的刺激作用。

The processes for preparation of tribenuron-methyl and its key intermediates were reviewed. Comparing the yield, quality, cost, safety and environmental protection and other aspects, the best production process of tribenuron-methyl is to use the methyl 2-benzoate and sodium cyanate as raw materials.

综述了苯磺隆及其关键中间体的主要生产工艺,并对各生产工艺在收率、质量、成本、安全环保等方面进行了比较和评价,指出了以邻甲酸甲酯苯磺酰氯、乙腈和氰酸钠为原料的工艺是苯磺隆的最佳生产工艺。

Microstrucfure of the powder samples achieved such as crystallographic structure, grain size, particle morphology, element analysis and thermal decomposition were characterized by means of X-ray diffraction, transmission electron microscopy, electron diffraction, energy dispersion X-ray spectroscopy and differential thermal analyzer etc.

结果表明,所制备的钠米镍粉、镍铜及镍铜硼复合粉呈颗粒均匀的球形或类球形,粒径在40nm~60nm之间。采用DTA方法对添加了纳米粉的高氯酸铵、AP/HTPB推进剂热分解情况进行表征。

RESULTS:The diffusive rate of diclofenac sodium from the two kinds of hydrophilic polymer gel was higher than that of diclofenac acid.

结果:在亲水的高分子凝胶基质中,离子形式的双氯芬酸钠扩散速率大于分子形成的扩散速率。

By mixing fatty acyl chloride, fatty acid and hydroxyethyl sodium dithionite, reacting in a normal-pressure reaction apparatus in a heated manner, the product is produced.

本发明IgeponA系列阴离子表面活性剂用脂肪酰氯、脂肪酸和羟乙基磺酸钠混合,在常压反应器中进行反应,加热反应一定时间后得产品。

Sodium5sulfoisophthalic acid dimethyl ester was prepared by sulfonation of mC 6H 4 2 with chlorosulphonic acid , treatment of the 5sulfoisophthalic acid with methanol to esterify the -CO 2H groups and separation of the product in the form of sodium salt of sulfonic acid.

研究了由氯磺酸和间苯二甲酸经磺化及酯化反应合成间苯二甲酸二甲酯磺酸钠盐的工艺方法,探讨了投料比、反应温度、催化剂用量和反应时间对产物的影

The sodium sulphonate of ethoxylated acrylic modified rosin can be obtained from acrylic modified rosin after the reaction with ethylene oxide and then be sulphonated with chlorosulphonic acid.

以松香为原料,用丙烯酸进行改性后再与环氧乙烷聚合,然后用氯磺酸进行磺化处理制得丙烯酸改性松香聚氧乙烯醚磺酸钠阴离子表面活性剂。

Study on the Effect of Azone on Percutaneous Absorption of Clindamycin Hydrochloride in Cream;2. OBJECTIVE To observe the effects of three transdermal enhancers( azone ,isopropyl myristate,oleic acid) in vitro under the condition of iontophoresis with diclofenac sodium as the model drug.

方法选择聚乙烯醇、聚乙烯吡咯烷酮、羟丙甲基纤维素为基质,制备了分别含有月桂氮酮、肉豆蔻酸异丙酯和油酸的双氯芬酸钠经皮离子导入凝胶,采用改良Franz纵向释放池,以人体皮肤为透皮屏障,进行药物凝胶的离子导入经皮试验。

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

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