氯酸酯

During the manufacturing of the critical intermediate cephalosporin nucleus --7-amino-3-chloro-cephalosporanic acid diphenylmethyl ester hydrochloride salt, first the feasibility of the one-pot synthetic route of open loop, closed loop and ozonization when chlorine is passed over is qualified by experiments. Then the critical factors that will influence this reaction are studied as follows: the mol ratio of triphenyl phosphite and Diphenylmethyl 3-hydroxy-7-phenylacetaminoceph-3-em-4-carboxylate-l-oxide is four to one; the quantity of the stablizer should be at least more than two to one. The temperature of the system must be 25℃ when chlorine is passed over so that the hydrochloride can be precipitated to obtain cephalosporin nucleus of cefaclor--7-amino-3-chloro-cephalosporanic acid diphenylmethyl ester hydrochloride salt.

在制备关键中间体头孢母核7-氨基-3-氯头孢烷酸二苯甲酯盐酸盐时，先通过实验验证把开环、闭环、臭氧化三步在通入氯气时并为一锅煮的合成路线的可行性之外，又研究了影响该反应的几个重要因素：亚磷酸三苯酯与3-羟基-7-头孢烷-5-亚砜-2-甲酸二苯甲酯的摩尔比为4：1；稳定剂2-甲基-2-丁烯的用量至少大于2：1，通入氯化氢气体时体系温度在25℃时盐酸盐则能够顺利析出，获得头孢克洛的头孢母核—7-氨基-3-氯头孢烷酸二苯甲酯盐酸盐。

A new method for synthesizing rosin allyl alcohol ester was studied. p-Toluenesulfonic acid allyl alcohol ester was first synthesized by O-acylation of allyl alcohol with p-toluene sulfonyl chloride, using NaOH as catalyst. Then rosin allyl alcohol ester was synthesized from sodium resinate and p-toluenesulfonic acid allyl alcohol ester.

探索了一种两步合成松香烯丙醇酯的新方法，即先以烯丙醇和时甲苯磺酰氯为原料，以NaOH为催化剂，通过O-酰化反应合成中间体对甲笨磺酸烯丙醇酯，再与松香钠皂发生亲核取代反应合成目标产物松香烯丙醇酯。

Water,butylene glycol,biosaccharide gum-1,ppg-26-buteth-26,panthenol,peg-40 hydrogenated caster oil,hydroxyethylcellulose,imidazolidinyl urea,saccharide isomerate,benzophenone-4,phenoxyethanol,triethanolamine,citrus aurantium dulcisoil,pentadecalactone,methylparaben,sodium hyaluronate,citric acid,butylparaben,ethylparaben,citrus aurantium amaraoil,propylparaben,methylchloroisothiazolinone,methylisothiazolinone,red 4,yellow 5,red 33,limonene,linalool

水，丁二醇，多醣物质，PPG-26-丁醇聚醚-26，维生素B5，PEG-40氢化蓖麻油，羟乙基纤维素，尿素醛，天然异构寡糖，二苯甲酮- 4，苯氧乙醇，三乙醇胺，甜橙油，环十五内酯，羟苯甲酯，透明质酸钠，柠檬酸，羟苯丁酯，羟苯乙酯，苦橙油，羟苯丙酯，甲基氯异塞唑晽酮，甲基异噻唑啉酮，红4，黄5，红33，柠檬精油，芳樟醇

In this paper, the thermally reversible crosslinking reaction and the properties of synthesized TPE based on the reactions of chlorine containing polymers such as PVC , chlorined polyethylene , epichlorohydrin rubber and acrylic rubber with salts of dicyclopenladienyl dicarboxylate crosslinking agents were studied.

本研究以环戊二烯二酸盐衍生物作热可逆共价交联剂，通过与聚氯乙烯、氯化聚乙烯、氯醚橡胶和丙烯酸酯橡胶等含氯聚合物的脱MX酯化反应来实现共价关联，并制取相应的新型TPE。

This dissertation is mainly focused on the reactivity of methylenecyclopropanes and comprises six parts. 1 The reactions of methylenecyclopropanes with phenylsulfenyl chloride, phenylselenyl chloride and diphenyl diselenide; 2 The coupling reactions of the ring-opening products derivated from methylenecyclopropanes; 3 The palladium-catalyzed ring-enlargement of mono-aryl group substituted methylenecyclopropanes to cyclobutenes. 4 The gold-catalyzed domino ring-opening and ring-closing hydroamination of methylenecyclopropanes with sulfonamides; 5 The Lewis acid-catalyzed reactions of mono-aryl group substituted methylenecyclopropanes with diethyl ketomalonate in the presence of water; 6 The iodobenzene diacetate mediated novel 1,3-dipolar cycloaddition of methylenecyclopropanes, vinylidenecyclopropanes, and methylenecyclobutane with phthalhydrazine.

本论文主要研究了亚甲基环丙烷类化合物的一些化学反应性能，共由以下六部分组成：1、亚甲基环丙烷类化合物与苯硫氯、苯硒氯及二苯基二硒的反应；2、亚甲基环丙烷类化合物开环产物的偶联反应；3、单芳基取代的亚甲基环丙烷类化合物在钯催化剂作用下的扩环反应；4、金化合物催化磺酰胺对亚甲基环丙烷类化合物的串联开环关环氨氢化反应；5、路易斯酸催化亚甲基环丙烷类化合物与丙酮二羧酸二乙酯在有水存在下的反应；6、醋酸碘苯促进的亚甲基环丙烷类化合物、亚乙烯基环丙烷类化合物及亚甲基环丁烷类化合物与邻苯二甲酰肼的新型1，3-偶极环加成反应。

A method for synthesizing sodium sulfoacetic is discussed,which sodium sulfoacetic is synthesized with sodium sulfite and ethyl monochloro acetate,with sodium sulfite and chloroacetic acid.

主要分别介绍用亚硫酸钠与氯乙酸乙酯合成磺酸乙酸钠和亚硫酸钠与氯乙酸合成磺酸乙酸钠。

The famciclovir was synthesized from purine by a series of steps by Acylation, Decarboxylation, Reduction ,and so on; Derivatives of these intermediates is described from the 6-chloro- 9H- purin-2-amine as raw materials in different conditions when the iodine and bromide were synthesized with the addition of two intermediate 6-bromo-9H-purin-2-amine and 6-iodo-9H-purin-2-amine; There is elaborated from the main part of a acetophenone, urineaminohydrochloride, phenylhydrazine, ethyl acetoacetate as raw material through a series of reactions to synthetic 3-phenyl-4-formylphenyl pyrazole and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-aldehyde two pyrazole aldehyde, and then with 2-amino-6-chlorine-9-(2-methicillin-oxo-co-methyl-4-yl) purine reaction of the two new pyrazole purine Schiff bases.

本论文主是采用以鸟嘌呤为原料，经过一系列的酰基化，脱羧，还原等反应作用下最终得到了产物2-氨基-9-(4-乙酰氧基-3-乙酰氧基甲基丁基)嘌呤；其中的中间体衍生物主要是阐述从以2-氨基-6-氯鸟嘌呤为原料通过在不同的条件下进行溴代与碘代分别合成了另外两种中间体2-氨基-6-溴鸟嘌呤及2-氨基-6-碘鸟嘌呤；还有一部分主要是阐述从以苯乙酮，盐酸氨基脲，苯肼，乙酰乙酸乙酯为原料通过一系列的反应先合成3-苯基-4-醛基吡唑及5-氯-3-甲基-1-苯基-1H-吡唑-4-甲醛这两个吡唑醛，然后再与2-氨基-6-氯-9-(2-甲氧羰基丁酸甲酯-4-基)嘌呤反应得到了两个新型的吡唑嘌呤席夫碱

Bezaldehyde was used as protective agent in first method.S-Epichloeohydrin was aminated and acidulated to give(2S)-1-Amino-3-chloro-propanol Salts.The acetylation of (2S)-1-Amino-3-chloro-propanol by acetic anhydride produced the intermediate-N-[2--3-chloropropyl]acetamide.And then at 20℃,in the presence of lithium tert-butoxide,benzyl 3-fluoro-4-morpholinophenyl carbamate react with-N-[2--3-chloropropyl]acetamide to give linezolid in total yield of 43.6%.

路线一采用苯甲醛作保护剂，使S-环氧氯丙烷氨解、酸化生成S-1-氨基-3-氯-2-丙醇盐酸盐，然后经乙酰化反应后，生成中间体-N-[2-乙酰氧基-3-氯丙基]乙酰胺，再用N-(3-氟-4-吗啉苯基)氨基甲酸苄酯和中间体在催化剂叔丁醇锂存在下25℃反应生成利奈唑酮，总产率达到43.6%。

Besides, n-butyl and sec-butyl tosylate that are difficult for oxidative addition can react with phenylmagnesium bromide to form corresponding cross-coupling products. Primary alkyl halide which contains β-hydrogen and is relatively hard to undergo the reaction , n-butyl chloride for instance, can react with aryl Grignard reagents in the presence of NiB alloy as well.

此外，难以进行氧化加成的对甲苯磺酸正丁酯和对甲苯磺酸仲丁酯可以与苯基溴化镁作用生成相应的交叉偶联产物；反应相对困难的含β-H的伯卤烷，如：正氯丁烷也可以在NiB催化下与芳基格氏试剂发生偶联。

Two types of haptens, the earboxylated propyl amino derivative of the acid moiety (HCA1) that is the hydrolyzed product of cyhalothrin, and the carboxylated ethyl carbonyl derivative of the alcohol moiety (HCB2) were synthesized, and conjugated with the carrier proteins bovine serum albumin and ovalbumin respectively by the active ester method and the mixed anhydride method. The polyclonal antibodies were obtained after immuning to the New Zealand rabbits.

通过对氯氟氰菊酯分子结构中的酸部分接4-氨基丁酸(HCA1)和醇部分接丁二酸酐(HCB2)，合成两种不同的半抗原，并通过碳二亚胺法将HCA1和HCB2分别与牛血清蛋白偶联制备了人工抗原HCA1-BSA和HCB2-BSA，通过活泼酯法将HCA1、HCAS和HCB2分别与卵清蛋白偶联制备包被抗原，两种人工抗原通过免疫新西兰大白兔来制备相应的多克隆抗体。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。