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氯胺酮

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Objective To explore the relationship between analgesia effect of Ketamine and NMDA receptor.

目的 观察氯胺酮的镇痛作用与N-甲基-D-天冬氨酸受体的关系。

But all the patients appeared to be anorectic on the day of operation.

低浓度、小剂量的氯胺酮复合异丙酚可用于无痛针刀闭合性手术。

Objective:To investigate the effect of ketamine on ventilator-induced lung injury in asthmatic rats.

目的:探讨氯胺酮对哮喘大鼠机械通气肺损伤的影响。

Result: The breath and circulation in group A is more steadily than those in group B during the operation(P.05).The incidence of body movement and larynx spasm is higher in group B(P .05).The quantity of ketamine is less in group A than group B.

结果:术中A组循环、呼吸功能较B组稳定(P.05);肢体不良自主运动,喉痉挛等不良反应较B组少(P.05);A组氯胺酮用量明显少于B组(P.01);术后A组苏醒较快且平稳。

Results During the operation, the breath and circulation in group A is more steadily than that in group B (P.05); the incidence of bodymovement and larynx spasm and the dosage of ketamine are lesser than that in group A. Postoperative children recovery is faster and more steadily in group A than those in group B.

结果 A组术中血压、心率和呼吸较接近麻醉前基础值,且术中波动较小,生命体征平稳。B组血压、心率及呼吸率均较术前明显增加,且始终保持在较高水平,随麻醉深浅而有显著波动。A组循环、呼吸功能较B组稳定(P.05);肢体不良自主运动,喉痉挛等不良反应较B组少(P.05);A组氯胺酮用量明显少于B组(P.01);术后A组苏醒较快且平稳,恢复期精神症状少,与B组比较差异有统计学意义(P.05)。

Catheterization measurements were repeated at 5,10, and 15 min after completion of ketamine load.

在七氟醚的共同作用下,氯胺酮并不增加自主呼吸的肺动脉高压儿童的肺血管阻力。

Objective To observe the effect of intrathecal injection of ketamine and clonidine for chronic constriction injury in rats.

目的:观察鞘内注射氯胺酮及可乐定对慢性神经病理性疼痛的镇痛效应。

200 forepart pregnant women with ASA Ⅰ~Ⅱgrade who free will stop gestation,they were divided into 4 groups randomly :P group was simplicity propofol; F group, T group and K group was mainlined fentanyl 0.75μg/kg,tramadol 1mg/kg,ketamine0.2mg/kg respective before propofol abduction, and continuous detected MAP,HR,SpO2 in the operation, and to note first dosage and total dosage of propofol, revival time, leave hospital time, ill reactivity in the operation.

200例ASAⅠ~Ⅱ级、自愿终止妊娠的早孕妇女随机分为四组:P组,单纯异丙酚麻醉组;F组、T组、K组在异丙酚诱导前分别静注芬太尼0.75μg/kg、曲马多1mg/kg、氯胺酮0.2mg/kg。术中连续监测MAP、HR和 SpO2。记录各组病人异丙酚的首剂量和总剂量、苏醒时间、离院时间及术中术毕不良反应的发生情况。

Multiple blood samples were taken for measurement of the time course of the drug concentrations, and the electrocorticogram processed (approximate entropy, for propofol and methohexital and percentage high frequency time, for ketamine) to numerically quantify drug effect.

结果:使用药代/药效分析法得出的t1/2Keo:氯胺酮为2.0±0.4min,异丙酚为2.7±1.1min,而美索比托的t1/2Keo为0.3±0.1min明显较前两者缩短。药代/药效分析法和总体守恒分析法在药物到达峰值的时间举无明显差异。

METHODS: After instrumentation with arterial and sagittal-sinus cannulae, electrocorticogram, and sagittal sinus Doppler flow measurement seven adult sheep were given a random sequence of short anesthetic infusions with methohexital, ketamine, and propofol.

斦otilde;法:7只羾,先在每只羾身举安置徨脉和失羶窦导管,脑皮层电图和失羶窦超声血流分析仪,然后随机给予小剂量的异丙酚,美索比托和氯胺酮进行短时间麻醉,同时采取多个血样标本和脑电图变化来评估药效。

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