氯噻

Methods 4-Hydroxy- benzonitrile was treated with sodium hydrogen sulfide and anhydrous magnesium chloride in dimethyl formamide to give thioamide, which was then directly cyclized with ethyl 2-chloroacetoacetate without separation to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(2) in one-pot; then 2 was formylated with Duff reaction adopting hexamethylenetetramine in trifluoroacetic acid to give ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(3); finally, the target compound was obtained by the treatment of 3 with hydroxylamine hydrochloride and sodium formate in formic acid.

采用"一勺烩"方法，以4-羟基苯甲腈为起始原料，首先与硫氢化钠和无水氯化镁在N，N-二甲基甲酰胺中反应，所得中间体不经分离，直接加入2-氯乙酰乙酸乙酯进行环合反应，得到2-(4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（2）；然后通过六亚甲基四胺/三氟乙酸进行Duff反应，得到2-(3-甲酰基-4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（3）；再经盐酸羟胺/甲酸/甲酸钠体系脱水得到目标化合物。

Our chief products include as follows: 5-Nitro-8-hydroxy Quinoline, 8-Aminoquinaldine, 8-Hydroxyquinoline Sulfate, 5,7-Dichloro-8-hydroxyquinaldine, 5-Nitro-0-cresol, 6-Nitro-m-cresol, 2'-Chloroacetophenone, 4-Methyl-5-thiazole ethanol, 4-Aminophenethyl alsohol.

主要产品有：硝羟喹啉，8-氨基喹啉，8-羟基喹啉硫酸盐，8-羟基喹哪啶，5，7-二氯-8-羟基喹哪啶，5-硝基邻甲酚，6-硝基间甲酚，邻氯笨乙酮，4-氨基笨乙醇，4-甲基-5-噻唑乙醇，3-羟基吡啶等。

Major procurement of goods: a three-chlorosilanes, dichloromethane, AE activity ester, 3-iodine Silane, special acid, pentyl chloride, triethylamine, thiadiazole, tetrazolylazo acid, 2 - Acetamide, tetrahydrofuran, the four-guanidine, isopropanol, five phosphorus trichloride, sodium vary bitter, acid, sodium phenylacetate, 6-2 silicon n-amine, Ethylacetoacetate , Methyl isobutyl ketone, potassium dihydrogen phosphate, aluminium oxide, DL methionine, N, N-dimethylaniline, NN-diethyl aniline, 4 sodium EDTA, Anhydrous sodium sulfate, ammonium sulfate, potassium sulfate, sodium acetate, sodium carbonate, DMC, formic acid, sodium chloride medicinal, oxalate, protopine, acetone, alcohol, acetic acid, vinegar Ethyl, butyl acetate, methanol, ethanol (anhydrous, industrial, medicinal), formaldehyde, Ye Jian (30%), hydrochloride (industrial-grade, refined grade, reagent level), sulfate (98%), Ammonia, calcium carbonate, chlorine dioxide, 6 - APA ,7-ACA ,7-ADCA ,7-ANCA, sulbactam, ceftazidime activity ester, Deng salt (hydroxymethyl-K, acid precursors Potassium, sodium dihydrogen methyl), resin, the enzyme, water treatment agent, Xiao Mo agent, demulsifier, flocculants, activated carbon, all kinds of medicinal materials, All kinds of additives

三甲基一氯硅烷、二氯甲烷、AE活性酯、三甲基碘硅烷、特戊酸、特戊酰氯、三乙胺、噻二唑、四氮唑乙酸、二甲基乙酰胺、四氢呋喃、四甲基胍、异丙醇、五氯化磷、异辛酸钠、苯乙酸、苯乙酸钠、六甲基二硅胺烷、乙酰乙酸乙酯、甲基异丁酮、磷酸二氢钾、三氧化二铝、DL蛋氨酸、N，N-二甲基苯胺、NN-二乙基苯胺、乙二胺四乙酸四钠、无水硫酸钠、硫酸铵、硫酸钾、醋酸钠、碳酸钠、碳酸二甲酯、甲酸、药用氯化钠、草酸、片碱、丙酮、正丁醇、冰醋酸、醋酸乙酯、醋酸丁酯、甲醇、乙醇、甲醛、液碱（30％）、盐酸（工业级、精制级、试剂级）、硫酸（98％）、氨水、碳酸钙、二氧化氯、6－APA、7－ACA、7－ADCA 、7－ANCA、舒巴坦、头孢他啶活性酯、邓盐(羟甲基钾、前体酸钾、二氢甲基钠)、树脂、生物酶、水处理剂、消沫剂、破乳剂、絮凝剂、活性碳、各种药用辅料、各种添加剂

By adopting novel Pummerer-cyanation route and by using thionyl chloride as S-transfer reagent, the first thieno [3,4-c] thiophene bearing all electron withdrawing groups has been synthesized.

设计采用新颖的Pummerer-氰化路线和用亚硫酰氯作S-转移试剂的路线合成了第一例全部连吸电子基的噻吩并[3，4-c]噻吩。

The same year with the Institute of Fine Chemicalto develop fine chemical products - o-aminobenzoic acid, and 1.4 million yuan of funds into an annual output of 200 tons built anthranilic acid production line, by the province for the Prohibition of Chemical Weapons Convention to fulfill the work of leadership Office approval in April 2002 with an annual output of 200 tons of the scale of operation, product quality compared with similar products in the domestic leading level, in October 2002 to carry out technical transformation again, the scale of production from 200 tons; years expanded to 500 tons; in size, and product performance, production capacity of plant expansion requirements, in 2003 officially put into operation. The end of 2004 our company moved to Sequoia small city are on the 1st, covering over 20,000 square meters, anthranilic acid after the removal of the production line expanded to 1200 tons; in size, at the same time developed a 2,2 - Dithio Benzophenone acid, benzo-iso thiazoline -3 - one, dichloro-acetonitrile, thiophene tons of ketones, a series of inter-amino benzoic acid, etc. Fine Chemical Products.

同年公司与上海桑迪精细化工研究所合作开发精细化工产品—邻氨基苯甲酸，并投入140万元资金建成了年产200吨邻氨基苯甲酸生产线，经省履行禁止化学武器公约工作领导小组办公室批准于2002年4月以年产200吨的规模投入运行，产品质量与国内同类产品相比处于领先水平，2002年10月公司再次进行技改，把生产规模由原来的200吨；年扩到500吨；年规模，且产品性能、生产装置能力达到扩产的要求，2003年正式投入运行。2004年末我公司搬迁至杉城小均1号，占地2万多平方米，搬迁后邻氨基苯甲酸生产线扩大到1200吨；年规模，同时开发了2，2-二硫代二苯甲酸、苯并异噻唑啉-3-酮、二氯乙腈、噻吨酮、间氨基苯甲酸等一系列化工精细产品。

In order to find biologically active urea compounds,seven new N-[5-(3-pyridyl)-1,3,4-thiadiazol-2-yl]-N'- urea derivatives were synthesized by the reaction of 2-amino-5-(3-pyridyl)-1,3,4-thiadiazole with aroylazides,which were prepared starting from carboxylic acids,ethyl chloroformate and sodium azide by one-pot procedure.

为了寻找高生物活性的脲类化合物，通过2-氨基-5-(3-吡啶基)-1，3，4-噻二唑与酰基叠氮化物反应，设计合成了7个新的N-[5-(3-吡啶基)-1，3，4-噻二唑-2-基]-N'-取代苯基脲，其中芳酰基叠氮化物是以芳酸、氯甲酸乙酯、叠氮化钠为起始原料采用&一锅法&所制得。

Phenothiazines were also oxidized byiodine and 2, 2, 6, 6- tetramethyl - 4 - acetyloxypiperidineoxoammonium hexachloroantimonate to radical cations in the cavityof β-cyclodextrins in aqueous solution.

以吩噻嗪衍生物为底物，2，2，6，6-四甲基-4-乙酰氧基哌啶氧铵六氯锑酸盐、碘为氧化剂，二者在水相中β-环糊精腔内发生了单电子转移反应，产生了吩噻嗪衍生物正离子自由基。

Methods 4-Hydroxy- benzonitrile was treated with sodium hydrogen sulfide and anhydrous magnesium chloride in dimethyl formamide to give thioamide, which was then directly cyclized with ethyl 2-chloroacetoacetate without separation to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(2) in one-pot; then 2 was formylated with Duff reaction adopting hexamethylenetetramine in trifluoroacetic acid to give ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(3); finally, the target compound was obtained by the treatment of 3 with hydroxylamine hydrochloride and sodium formate in formic acid.

采用&一勺烩&方法，以4-羟基苯甲腈为起始原料，首先与硫氢化钠和无水氯化镁在N，N-二甲基甲酰胺中反应，所得中间体不经分离，直接加入2-氯乙酰乙酸乙酯进行环合反应，得到2-(4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（2）；然后通过六亚甲基四胺/三氟乙酸进行Duff反应，得到2-(3-甲酰基-4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（3）；再经盐酸羟胺/甲酸/甲酸钠体系脱水得到目标化合物。

And we say because of the meta-analysis showing that β blocker in general and Atenolol in particular may not be as effective as other anti-hypertensive drugs, because of the LIVE trial, because of the ASCOT trial, which shows that the atenolol and thiazide are less effective than the amlodipine and thiazide arm.

之所以这么说是因为，有荟萃分析显示，β受体阻滞剂，具体说来就是阿替洛尔的疗效不如其他降压药物，LIFE试验、ASCOT试验的结果都支持这一点，这些试验的结果显示，阿替洛尔和噻嗪类利尿剂联合治疗的疗效比不上氨氯地平和噻嗪类利尿剂联合治疗。

And we say because of the meta-analysis showing that β blocker in general and Atenolol in particular may not be as effectie as other anti-hypertensie drugs, because of the LIE trial, because of the ASCOT trial, which shows that the atenolol and thiazide are less effectie than the amlodipine and thiazide arm.

之所以这么说是因为，有荟萃分析显示，β受体阻滞剂，具体说来就是阿替洛尔的疗效不如其他降压药物，LIFE试验、ASCOT试验的结果都支持这一点，这些试验的结果显示，阿替洛尔和噻嗪类利尿剂联合治疗的疗效比不上氨氯地平和噻嗪类利尿剂联合治疗。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新