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氯喹

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Ill start her on paromomycin and chloroquine.

我会开始给她进行巴龙霉素和氯喹的治疗

Drugs: There are certain drugs like chloroquine, which lead to temporary deafness.

药品:有某些药物如氯喹,从而导致暂时性耳聋。

In our study, systematically investigated the effect of chloroquine on exogenous gene expressing in mice by hydrodynamics-based naked plasmid adminstration was reported.

我们首先系统的研究了氯喹对裸质粒介导的人凝血Ⅸ因子在小鼠体内表达的影响。

Patients with platelet aggregation by 10 μmol adenosine 5'-diphosphate 70% were defined as nonresponders.

加 10 μmol腺苷5'-氯喹70%血小板聚集的病人被认为是无效者。

The effect of hydroxychloroquinein the treatment of discoid lupus ery thematosusand its side effects were observed.

观察硫酸羟氯喹HCQ治疗盘状红斑狼疮DLE的疗效并分析其副作用。

Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯-4-硝基苯酚和2-氯甲基吡啶为起始原料,经醚化、硝基还原得到3-氯-4-(吡啶-2-甲氧基)苯胺,3-氯-4-(吡啶-2-甲氧基)苯胺与3-氰基-6-乙酰氨基-7-乙氧基-4-氯喹啉反应得到3-氰基-6-乙酰氨基-4-[3-氯-4-(吡啶-2-甲氧基)苯氨基]-7-乙氧基喹啉,3-氰基-6-乙酰氨基-4-[3-氯-4-(吡啶-2-甲氧基)苯氨基]-7-乙氧基喹啉去乙酰保护基后,与-4-二甲氨基-2-丁烯酰氯经酰化反应得到ner-atinib。

Results In vitro ,daphnetin exhibited potent schizontocidal activity comparable to chloroquine at the dose range of 1~10 μmol/L. In vivo ,50 or 100 mg/kg.d -1 ×4 d daphnetin i.g. and 10,50 or 100 mg/kg.d -1 ×4 d dephnetin i.p. showed antimalarial efficacy comparable to CQ 10 mg/kg.d -1 ×4 d i.g. in mice infected with P. berghei ANKA, evaluated by both the reduction rate of parasitemia on D 4 and the average surviving days in 30 days.

结果 体外试验中瑞香素在 1~ 10 μmol L剂量范围内有明显杀灭裂殖体作用,而体内试验中按D4减虫率与感染鼠在 30d内的平均生存天数评价,5 0或 10 0mg kg 。d- 1 × 4d瑞香素灌胃以及 10 ,5 0或 10 0mg kg.d- 1 × 4d瑞香素腹腔注射给药在伯氏鼠疟原虫ANKA株感染鼠中的抗疟作用与 10mg kg 。d- 1 × 4d氯喹灌胃的疗效相似。

The decomposition of phosphatide,the increase in the content of MDA and the decreases in the activities of ATPases in pulmonary cellular membrane might be important factors of the occurrence and the development of smoke inhalation injury.

肺细胞膜磷脂分解、丙二醛含量增加和ATP酶活性降低可能是烟雾吸入伤发生发展的重要原因;氯喹部分改善ATP酶活性、降低丙二醛含量、稳定细胞膜而对烟雾吸入伤具有防治作用。

Methods Using 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives.

方法以4氯2硝基苯胺为起始原料经取代、还原关环、氧化、和氯代合成了中间体2,7二氯喹喔啉(7),再在喹喔啉的2位引入不同的取代酚结构单元,合成了一系列共9个新喹喔啉衍生物。

Malaria is now highly resistant to a previous wonder drug

现在疟疾对以前的一种特效药氯喹已具有极高的抗药性

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力