氯乙酸

In this study, the effects of adding chlorophenol, acetic acid and ozone were investigated separately in order to further study the mechanism of UV induced enhancement. The experimental results showed that adding acetic acid into the inlet gas decreased the chlorobenzene removal rate of the biofilter.

为了考察紫外预处理对生物过滤塔的影响机理，本研究分别考察了氯苯紫外光降解主要产物氯酚、乙酸以及副产物臭氧对生物过滤塔运行性能的影响。

In this paper, Claisen condensation of isochroman ?4?one as starting material with diethyl oxalate is carried out to form β?diketone compound of isochroman ?4?one.

以异色满酮 4为起始原料，经Claisen缩合得其β二酮衍生物，再与水合肼进行Knorr反应环合成 3 乙氧甲酰基和 3 肼甲酰基异色满并吡唑衍生物，通过酰肼与糠醛反应成腙后，分别与巯基乙酸和氯乙酰氯反应合成了标题化合物

objective to observe the antitumor activities of different solution extracts of plumbago zeylanica l.in vitro.method mtt method was used to detect the inhibitory effects on four kinds of cancer cells.results chloroform extracts had significant inhibitory effects on the breast cancer cell(bre-04),the nerve cancer cell(n-04) and the lung cancer cell(lu-04),ic50 were 0.2699mg/ml and 0.2634mg/ml,0.4961mg/ml respectively.ic50 of chloroform extract on the hepg2 was 0.9379mg/ml.ic50 of petroleum ether extracts on bre-04,n-04,lu-04 and hepg2 was 0.5902mg/ml,0.5725mg/ml,0.7938mg/ml,0.6374mg/ml;ethyl acetate extracts had fairly inhibitory effects on the lu-04,ic50 was 0.7343mg/ml;n-butanol extracts and water-solubility extracts had notsignificant inhibitory effects on the four kinds of cancer cells.conclusion the antineoplastic effective parts of plumbago zeylanica l.were chloroform and petroleum ether extracts.

目的 探讨白花丹体外抗肿瘤作用的活性部位。方法 mtt染色法对白花丹五种溶剂提取物体外抗肿瘤活性进行了初步的研究。结果氯仿提取物对乳腺癌细胞（bre-04）、神经癌细胞（n-04）、肺癌细胞（lu-04）有较好的抑制生长作用，ic50分别为0.269 9 mg/ml、0.263 4 mg/ml、0.496 1 mg/ml，对肝癌细胞hepg2抑制作用差， ic50为0.937 9 mg/ml；白花丹石油醚提取部位对乳腺癌细胞（bre-04）、神经癌细胞（n-04）、肺癌细胞（lu-04）、肝癌细胞hepg2的ic50分别为0.590 2 mg/ml、0.572 5 mg/ml、0.793 8 mg/ml、0.637 4 mg/ml；乙酸乙酯提取物对肺癌细胞（lu-04）有一定的抑制作用，ic50为0.734 3 mg/ml；水溶性提取物以及正丁醇提取物无明显抑制肿瘤作用。结论白花丹氯仿提取部位、石油醚提取部位体外抗肿瘤作用较好，值得对其提取部位进一步分离纯化并研究其抗肿瘤作用机制。

Project Background and Conditions: The company started research new chemical products in 1998. After two years of efforts, a series of pharmaceutical intermediate sulfathiazole leave instructions, including : 3- methyl sulfathiazole leave instructions, 2- sulfathiazole leave instructions ethanoic acid, 2- acetyl sulfathiazole leave instructions, 2-thiofuran amino ethane ,2-thiofuran acetic, 3,4,5- tighter nitrobenzene have been successfully developed. 2-thiofuran amino ethane are the precursors raw materials of series antibiotic analgesic.

二、项目建设背景及条件：1998年公司开始研究开发高新精细化工产品，经过两年的努力，已成功研制出噻吩系列医药中间体，包括：3-甲基噻吩、2-噻吩乙酸、2-乙酰噻吩、2-噻吩乙胺、2-噻吩乙醇、3，4，5-三氯硝基苯等。2-噻吩乙胺系列噻吩产品使用于血小板及血栓有关的心脏血管病及消炎镇痛等如氯吡格雷、兴孢噻吩钠、兴孢西丁、噻吩洛酸等十几种新药的前体原料，是国家政策鼓励发展和有自主知识产权的项目。

Chemiluminescent immunoassay is one of the advanced immunoassay ofnon-radioisotopic immunoassay because of its high sensitivity, wide dynamic range,high accuracy, stable labeled protein, full automation and extensive application field.CLIA using acridinium ester derivatives as chemiluminescent label has advantages oflow background, high signal-to-noise ratio, no need of catalyst and simpleluminescence system. Different aspects associating the DMAE·NHS-based CLIA were studied in thisthesis, including synthesis of acridinium ester, chemiluminescentcharacteristics of DMAE·NHS, labelling antibody or streptavidin with DMAE·NHS,two-site sandwich chemiluminescent immunoassay for TSH, two-sitesandwich chemiluminescent immunoassay involved biotin-streptavidinsystem for TSH, and competitive chemiluminescent immunoassay usingbiotin-streptavidin system for TT〓. The desired acridinium ester, DMAE·NHS, was synthesized according to thereference method with some modifications. The products were identified by IR, NMR,MS and elemental analysis. In our method, KOH was used in place of NaOH tosynthesize benzyl ester of 3,5-dimethyl-4-hydroxybenzoic acid,2',6'-dimethyl-4'-(n-succinimidyloxycarbonyl) phenyl-acridinium-9-carboxylate waspurified on a silica gel column with chloroform/ethylacetate(4:1, v/v) as eluent andfurther purified by triturating with hexane/acetone(2:1, v/v).

DMAE·NHS的合成是本论文的关键和难点，我们对文献方法进行改进：文献方法用氢氧化钠与3，5-二甲基-4-羟基苯甲酸反应制得3，5-二甲基-4-羟基苯甲酸钠，再用3，5-二甲基-4-羟基苯甲酸钠与苄氯作用制备3，5-二甲基-4-羟基苯甲酸苄酯，我们用氢氧化钾代替氢氧化钠，使合成取得成功；在合成2'，6'-二甲基-4'-苯基-吖啶-9-甲酸酯时，文献方法对粗产品进行两次硅胶柱层析纯化，第一次柱层析用氯仿／乙酸乙酯(4∶1，V∶V)作溶剂和淋洗剂，第二次柱层析用己烷／丙酮(2∶1，V∶V)作溶剂和淋洗剂，按照文献方法得到的不是所需要的化合物，我们只进行第一次柱层析纯化，然后用己烷／丙酮(2∶1，V∶V)进行研磨，过滤，洗涤，除去溶于己烷／丙酮(2∶1，V∶V)的部分，得到所需要的产品。

Bromination of 4-chloropropiophenone with Br2 in AcOH gives a-bromo-4-chloropropiophenone in 98% yield.

乙酸中用液溴溴化对氯苯丙酮得到α-溴代对氯苯丙酮，收率98%。

DPPH method, pyrogallol method and Fenton reaction were used to study the scavenging ability of extracts with 95% ethanol, ethyl acetate, acetone, acetic acid, chloroform, methanol to free radical activity.

方法］应用DPPH法、邻苯三酚自氧化法和Fenton反应分别研究了浓度95%乙醇、乙酸乙酯、丙酮、乙酸、氯仿、甲醇提取物清除自由基活性的能力。

In view of the existence of the above shortcomings of traditional methods, using acetyl chloride instead of acetic acid as a raw material, do not use any catalyst, not heating, room temperature reaction synthesis of ethyl acetate.

鉴于传统方法存在以上缺点，采用乙酰氯代替乙酸作为原料，不使用任何催化剂，不加热，常温反应来合成乙酸乙酯。

Continuous use of a disinfectant solution for long periods eventually results in dilution or decreased activ- ity.89 Commercial test kits are available for chlorine, hydrogen peroxide, glutaraldehyde, and peracetic acid to determine whether an effective concentration of active ingredients is present

消毒溶液的长时间持续使用最终导致溶液的稀释或活性降低。商业测试包可以用于测试氯制剂、过氧乙酸、戊二醛和过氧乙酸在重复使用和稀释后活性成分的有效浓度。但是此类测试包的可靠性尚未确定。

The major occupational hazards factors in printing ink were benzene, toluene, xylene, ethylbenzene, solvent gasoline, methanol, alcohol, isopropyl alcohol, ethyl acetate, butyl acetate, butyl acetate, dichloromethane, etc. 10 of 1224 samples (0.82%) exceeded the national occupational health standards.

印刷油墨中存在的职业病危害因素种类主要有苯、甲苯、二甲苯、乙苯、溶剂汽油、甲醇、乙醇、异丙醇、乙酸乙酯、乙酸丁酯、二氯甲烷等，检测样品总数1224件，超标样品数10件，超标率为0.82%。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。