氯丙嗪

Methods Before treatment, the first hemospasia and BPRS evaluation were taken, and indices of blood rheology measured using XNs Electron Auto Whole Blood Viscosity Red Cell Electrophoresis Apparatus (researched and produced by Shanghai Medical University) in the 32 schizophrenics.

经氯丙嗪治疗2周后，重复上述实验及第2次BPRS评定。统计学处理采用t检验。结果32例精神分裂症病人治疗前血液流变学指标较正常人有明显异常，经氯丙嗪治疗后，全血高切变、全血低切变、红血球压积和红血球电泳时间有显著下降，同时BPRS评分也下降，其差异均有显著意义（P＜0.05）。

In addition, we have developed some sensors for phenothiazine drugs and some Chinese medicinal herbs. In last 3 years, we have published 20 SCI papers, and composed two review papers for the international journals.

另外，我们还开展了异丙嗪和氯丙嗪及马兜磷酸等药物传感器以及仿生环境中神经递质多巴胺的电化学检测等相关工作的研究，取得了一定成果。

Chlorpromazine hydrochloride and promethazine hydrochloride were oxidized fastly resulting in red intermediate product,which was then gradually changed into a colorless product by ammonium cerous sulfate in appropriate acidic medium.

盐酸氯丙嗪和盐酸异丙嗪在适当的硫酸介质中均能被硫酸铈铵快速氧化成红色化合物，该化合物又逐步被氧化成无色物质，两种药物的动力学过程的差异较小，动力学曲线相似。

The products produced throughout the year are :Chlopromazine Hydrochloride ;Metformin Hydrochloride ,Clozapine,Glipizide etc.in which Pheny butazone Metformin Hydrochloride and Clozapine have achieved the American FDA Certificate.

上海市医药股份有限公司第十五制药厂建于1931年，生产盐酸二甲双胍、格列吡嗪、氯氮平、保泰松、盐酸氯丙嗪等29个产品，其中，盐酸二甲双胍、氯氮平、保泰松这三个产品已通过美国FDA认证。

Results For single treatment groups,serum drug concentration of chlorpromazine and clozapine were related to age of patients (P＜0 05),concentration of clozapine was related to dosage (P=0 01).For combination group,concentration of chlorpromazine was related to dosage (P＜0 01),also related to scores of PANSS and general psychopathological symptoms (P=0 01),concentration of clozapine was related to scores of PANSS,negative and general psychopathological symptoms (P＜0 05).Multiple linear regression analysis showed that forms and methods of treatment affected concentration of chlorpromazine,age of patients and methods of treatment affected concentration of clozapine.

结果 单用氯丙嗪和采用氯氮平组的血药浓度均与年龄相关（P＜0 05），氯氮平血药浓度与剂量线性正相关（P=0 01）；在双氯组中的氯丙嗪血药浓度与剂量线性正相关（P＜0 01），与PANSS总分及一般精神病理分相关（P=0 01），而氯氮平血药浓度与PANSS总分、阴性量表分及一般精神病理分明显相关（P＜0 05）；多元回归分析显示，治疗形式和治疗方法影响氯丙嗪血药浓度，年龄和治疗方法影响氯氮平血药浓度。

Part 2In this study, we have shown with the use of UV-visible spectrophotometry and the constant wavelength synchronous fluorescence spectroscopy techniques that the pharmaceutical drug, chlorpromazine hydrochloride, intercalates into the deoxyribonucleic acid double helix by partial exchange with the Neutral Red molecular probe.

第二部分，本工作结合紫外可见分光光度法和三维同步荧光法分别研究了中性红、盐酸氯丙嗪与DNA的作用，并利用中性红作探针来进一步研究盐酸氯丙嗪与DNA的作用以及它们二者与DNA之间的竞争作用。

Results showed that there were significantly positive linear correlations between the toxic effects（probits of mortality and inhibition rate） of chlorpromazine on the two aquatic organisms and the concentrations of chlorpromazine, and the toxic intensity became higher as the exposure time increased. The LC50 values of chlorpromazine acting on Carassius auratus in 24, 48 and 96h were 1.11, 0.43 and 0.32mg·L-1, respectively; and its safe concentration for Carassius auratus was 19.5μg·L-1. The LC50 and EC50 （50% of the tested Daphnia magna inhibited） values of chlorpromazine acting on Daphnia magna in 24h were 0.65 and 0.57mg·L-1, and the LC50 and EC50 values in 48h were 0.36 and 0.28mg·L-1, respectively. Thus, chlorpromazine have high toxicity to Carassius auratus and Daphnia magna, and the latter is more sensitive to chlorpromazine.

结果表明：氯丙嗪对两种水生生物的毒性效应（致死率、抑制率概率单位）均与其浓度呈显著线性正相关关系（p.05），且毒性强度随作用时间的延长而增加；氯丙嗪对鲫鱼的24、48和96h的半致死浓度（LC50）值分别为1.11、0.43和0.32mg·L-1，通过计算求得氯丙嗪对鲫鱼的安全浓度为19.5μg·L-1；氯丙嗪对大型蚤的24h LC50值为0.65mg·L-1，24h EC50值（使50%受试大型蚤活动受抑浓度）为0.57mg·L-1；48h LC50值为0.36mg·L-1， 48h EC50值为0.28mg·L-1；对鲫鱼和大型蚤而言，氯丙嗪属极高毒性物质，大型蚤对氯丙嗪的敏感性大于鲫鱼。

Nitrogen mustard drugs, mercaptopurine, cytarabine, large doses of chloramphenicol, chlorpromazine, imipramine, propylthiouracil, methimazole to the card than the horse yl, sulfa drugs can cause .

氮芥类药物、巯嘌呤、阿糖胞苷、大剂量的氯霉素、氯丙嗪、丙米嗪、丙基硫氧嘧啶、地巴唑、卡比马唑、磺胺类药物等均可引起。

The result showed that the limit of detection was 10μg/kg for chlorpromazine and promethazine.

结果表明，氯丙嗪和异丙嗪在猪肾脏中的最低检测限均为10μg/kg。

Clozapine and chlorpromazine can affect BG metabolism of patients with chronic schizophrenia, and clozapine even more obviously.

氯氮平和氯丙嗪均影响慢性精神分裂症患者的血糖代谢，氯氮平较明显。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。