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氮饱和

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This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物;其中:R 1 为选自基团和的部分;n为整数1或2;R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环;R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素;R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基;R 5 为OH或-OH 8 ;R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基,或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环;R 8 为具有1到12个碳原子的视情况经取代的烷基;或其互变异构体或医药学上可接受的盐。

The method of phenanthroline-Fe2+reaction system and autoxidation reaction system of pyrogallol and the system of lipid peroxide were used to measure the antioxidation of the water extraction from C.

本文采用邻二氮菲-Fe2+氧化法,邻苯三酚自氧化法以及卵黄脂蛋白不饱和脂肪酸过氧化体系,对甘青铁线莲花水提取物清除超氧阴离子自由基O2-。

Then two series of yellow sulfonamide dyes are synthesized by the reaction of the sulfonyl chlorides and ammonia or different fatty amines in the presence of acid-binding reagent. The structures of sulfonyl chloride intermediates and sulfonamide dyes are confirmed by FTIR,~1H NMR and mass spectrometry.

将所合成的磺酰氯化合物在缚酸剂作用下分别与含有不同碳数的饱和脂肪胺发生缩合反应,合成了两个系列黄色偶氮型磺酰胺染料,并利用红外光谱、核磁共振氢谱和质谱表征了磺酰氯中间体和磺酰胺染料的分子结构。

The experiment, in which the two times saturated-D optimal design was adopted, involving 3 factors, each with 5 levels, were conducted to study the fertilization amount for banana summer squash in Eco-organic type soilless culture system.

本试验利用三因素二次饱和-D设计,对香蕉西葫芦生育期中氮、磷、钾三种元素进行DPS分析,得到回归模型为: y= 543.7581 + 22.3308X1 + 7.9281X2 + 69.5503X3 + 20.8152X1X2 + 27.3437X1X3 + 65.6910X2X3 - 103.5530X12 + 8.6026X22 -

Laccase could degrade the conjugated resin acids and unsaturated fatty acids in model emulsions to some extend in the presence of ABTS2,2\'-azinobis(3-ethylbenzthiazoline-6-sulfonate or VIO.Palustric acid and abietic acid in DCS of Masson pine CTMP could be partially removed by lacaase treatment without addition of external mediator.

漆酶在ABTS2,2-连氮-二(3-乙基苯并噻唑-6-磺酸或紫尿酸存在的条件下可以降解带有共轭双键的树脂酸和不饱和脂肪酸;在不加介体的情况下漆酶处理可以除去马尾松CTMP的DCS样品中的部分长叶松酸和枞酸。

Amino-2-methylpropanol was utilized as a chemical modifying reagent to modify carboxyl groups in unsaturated fatty acids into nitrogen-containing heterocycles, which effectively suppressed the migration of double bonds of the alkenyl within the electron impact source and led to regular informative mass spectra indicative of the position of the olefinic bonds in the chain.

以2-氨基-2-甲基丙醇为脂肪酸的化学修饰试剂,将不饱和脂肪酸羧基化学修饰试剂,将不饱合脂肪酸羧基化学修饰成含氮杂环,从而避免了链烯基中碳碳双键在EI源中的移动,并使质谱呈现显示双键位置的规范信息。

METHODS: Fluoxetine and internal standard clozapine were extracted from plasma with ethyl acetate after being alkalized by sodium carbonate saturated solution.

以氯氮平为内标,血浆样品用饱和碳酸钠溶液碱化,经乙酸乙酯振荡萃取后,进样分析。

To improve the effect of CDCA on dissolving cholesterol gallstone, the water-soluble copolymers as polycarboxylic acid of comb-like copolymers and C_(60)-PCC were synthesized, which being used for modification of CDCA and strengthening effects of CDCA on dissolving the cholesterol gallstones by their entropy-repelled properties of comb-shaped side chains in buffers of phosphate and in model bile.The design theory of polymer was mainly employed to synthesis the conjugate of PCC-CDCA and C_(60)-PCC-CDCA by C_(60), polyoxyalkylene allylalkyldiether and maleic anhydride, which were copolymerized with AIBN as initiator, and then PCC or C_(60)-PCC were reacted with CDCA. The structures of the copolymers and the conjugates of PCC-CDCA and C_(60)-PCC-CDCA were confirmed with IR, TLC and TEM. The dissolving effects and the dissolution kinetics mechanism of cholesterol gallstone was inverstigated in PBS and in model bile of different cholesterol saturated index at pH7.4, including PCC-CDCA or C_(60)-PCC-CDCA.

利用高分子设计理论,以烯丙基聚氧乙烯基醚、顺丁烯二酸酐、C_(60)和CDCA为原料,以偶氮二异丁腈为引发剂,合成具有梳状侧链结构的梳状共聚物-CDCA结合物和C_(60)-梳状共聚物-CDCA结合物,以IR、TLC和TEM法表征共聚物的结构,并在pH7.4的PBS液和不同胆固醇饱和指数的模拟胆汁中进行溶石效果的研究,探讨在PBS液和不同CSI的模拟胆汁中结合物溶解胆固醇结石的效果和溶解动力学机制。

Yet chlorides of these metals will react with ammonia in which the valences of nitrogen and hydrogen are already satisfied

但这些金属的氯化物仍能和氨发生反应而在氨中,氮和氢的化合价已经饱和了

Yet chlorides of these metals will react with ammonia in which the valence s of nitrogen and hydrogen are already satisfied

但这些金属的氯化物仍能和氨发生反应而在氨中,氮和氢的化合价已经饱和了

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