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Starting from 3-benzoyl-5-formyl-indolizine, 3-benzoyl-5-(2'2'-diacetylethenyl)-indolizines and analogs were obtained by the 〓mediated aldol condensation or Wittig reaction. These compounds,promoted by low-valent titanium, gave highly functionlizedcycl[3,2,2]azine derivatives. The coupling reaction proceeded betweenthe carbonyl group and the carbon-carbon double bond, a rare example inMcMurry reaction.

我们以3-苯甲酰基-5-甲酰基中氮茚为原料,通过三碘化钐促进的aldol反应和Wittig反应制备了3-羰基-5-羰基乙烯基中氮茚,随后经低价钛还原偶联,没有生成正常的分子内羰基-羰基偶联产物,而是得到反常的羰基与α,β-不饱羰基的双键偶联产物,较高收率地得到了含多官能团的CycI[3,2,2]azine衍生物。

Use biochemical method to observe the effect of electro-acupuncture on AchE、SOD、MAO、NO、NOS of senile dementia AD rat's brain tissue; use immunohistochemistry technique to observe protein kinase expression of hippocampal; use optical and electron microscope to observe morphosis change of rat's brain tissue; use in situ hybridism technique to observe aspartate receptor mRNA expression of hippocampal; use water and electric maze experiment to observe rat escape latent period and mistake times, to understand it's learning and memory ability.

分别用生化方法观察电针对AD大鼠脑组织胆碱酯酶、超氧化物歧化酶、单胺氧化酶、一氧化氮、一氧化氮合酶的影响;用免疫组化方法观察海马组织蛋白激酶的表达;用光、电镜方法观察大鼠脑组织形态结构的变化;用原位杂交方法观察海马组织天门冬氨酸受体rnRNA的表达;用水迷宫和电迷宫实验观察大鼠逃避潜伏期和错误次数,以了解其学习记忆能力。

The DNA methylation level in stem apices treated with 5-azaC was comparable to that of seedlings treated at 5℃ for 10 days.

本文研究了去甲基化因子5-氮杂胞苷(5-azaC)对萝卜开花及幼苗茎尖DNA甲基化水平的影响。

In this thesis, we did modifications of alkyl groups upon benzyl fluorophosphonate. In order to study the influence of alkyl length and steric effect on activity and selectivity of probes, we synthesized benzyl fluorophosphonate recognition heads with modifications including ethyl, butyl, octyl and cyclohexyl. By way of connecting different kinds of tag like azido group, biotin and rhodamine with recognition heads separately through a higher hydrophilic ethylene glycol derived linker, a series of benzyl fluorophosphonate probes were made up. And they will apply to various biological testing strategies.

在本论文中,我们以苯甲基氟化磷酸酯为基础,於其上进行一系列烷基之修饰,为了探讨烷基长度与空间立体性质对於探针活性及选择性的影响,我们合成了包含乙烷基、丁烷基、辛烷基以及环己烷基修饰的苯甲基氟化磷酸酯辨识端,并藉由具较高亲水性的聚乙二醇衍生连接桥结合三种不同的发报端,分别有叠氮基团、生物素及萤光基团来构成不同的化学探针组合,这一系列苯甲基氟化磷酸酯类化学探针将可被应用於不同的生物测试策略。

Methods The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 7-nitroindazole (7-NI) on nitric oxide synthase activity, levels of dopamine、3,4-dihydroxyphenylacetic acid、homovanillic acid, and TH-immunostained postive nerve fibres in the striatum of mice were determined by using colorimetic analysis, HPLC with electrochemical detection, and immunohistochemical analysis.

用比色分析、高效液相色谱电化学及免疫组化法检测1-甲基-4-苯基-四氢吡啶和7-硝基吲唑(7-NI)对C57BL小鼠纹状体一氧化氮合酶活性,多巴胺、二羟基苯乙酸、高香草酸水平和酪氨酸羟化酶免疫阳性神经纤维的影响。

The nitrogen in the coal exists in the forms of pyridine (N-6), pyrrolic and pyridone (N-5), quaternary nitrogen and nitrogen oxides. The N-Q near 401.5eV is assigned to a protonated or oxide form of pyridinic nitrogen. On this basis, the nitrogen in six-membered rings is the dominant in Yibin coal.

研究结果表明,宜宾煤中氮的官能团有4种,即吡啶(N-6)、吡啶(N-5)、质子化吡啶和氮氧化物,其中吡咯含量最大,煤中的N-X就是N-O,是煤中吡啶结构氮与氧直接结合的结果。

Compared with extruded full fat soy bean, the oil of SPFFSB was more stable during storage.

结果表明同膨化工艺相比,热处理大豆的贮藏稳定性好于膨化大豆,KOH氮溶指数和脲酶活性均达到饲用要求。

Our results suggest that the mechanism leading to increased expression of 1-acid glycoprotein and consecutive increased protein binding of atracurium is not mediated by inducible nitric oxide synthase induction and nitric oxide expression.

我们的结论是1-酸糖化蛋白的表达和阿曲库铵与其结合的持续增加不是由诱导性氧化亚氮合酶和氧化亚氮所介导

Resistance to atracurium as a result of increased drug binding to 1-acid glycoprotein is associated with increased inducible nitric oxide synthase activity and increased nitric oxide levels in plasma.

对于阿曲库铵的阻滞是由于增加了诱导性氧化亚氮合酶活性和氧化亚氮在血浆中的水平从而使阿曲库铵与1-酸糖化蛋白的结合增加的结果。

On the basis of the above N-vinylaiton of amides,the Cu-catalyzed intramolecular C-S coupling of thiols was implemented for the first time with CuI (10 mol%) as the catalyst and K_3PO_4·3H_2O2 equiv.

在酰胺氮烯基化研究的基础上,我们进而开展了烷基硫醇分子内烯基化反应研究。

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Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书,王祥生,李德昌。安徽省首次发现嗜群血蜱。

Chapter Three: Type classification of DE structure in Sino-Tibetan languages.

第三章汉藏语&的&字结构的类型划分。