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AIM: To investigate the effect of aminoguanidine on plasma and renal levels of angiogenesis Ⅱ, and to identify the relationship of AGEs with AngⅡ in STZ-induced diabetic rats.

目的: 观察早期应用氨基胍对糖尿病大鼠循环及肾脏血管紧张素Ⅱ水平的影响,探讨其对糖尿病肾脏形态、功能的保护作用及潜在AGEs与AngⅡ之间的作用关系。

L-Arg, L-NNA and aminoguanidine had no effect on the iNOS mRNA expression.

而L-Arg、NOS抑制剂L-NNA及氨基胍均不影响胰腺组织iNOS基因水平的表达。

KEY WORDS tetromethylpyrazine; aminoguanidine; diabetic nephropathy; vascular endothelial growth factor

关键词]川芎嗪;氨基胍;糖尿病肾病;血管内皮细胞生长因子

Objective To investigate the inhibitory effects of aminoguanidine,a selective inhibitor of inducible nitric oxide synthase, on mice stomach cancer and its′mechanism.

目的:研究诱导型一氧化氮合酶选择性抑制剂氨基胍对皮下接种MFC胃癌细胞株小鼠的抑瘤作用,探讨其抑瘤机制。

Aminoguanidine was supplied by Sigma, USA.

氨基胍由美国Sigma公司提供。

Objective To study the effects of inducible NOS inhibitor aminoguanidine on the expression of NOS in facial nerve and surrounding tissue of traumatic facial paralysis rats.

目的 研究诱导型一氧化氮合酶抑制剂氨基胍对创伤性面瘫大鼠外周面神经及周围组织一氧化氮合酶表达的影响。

When compared with DM group, the thyroid tissue injury of insulin intervention group and aminoguanidine intervention group were lessened to different degree.

胰岛素和氨基胍干预组甲状腺组织超微结构较DM组有不同程度的减轻。

Vitamin E and aminoguanidine attenuate the production of Dia.

结论AGEP-BSA能升高培养的大鼠血管平滑肌细胞中的Dia水平,维生素E 和氨基胍能明显抑制这一效应。

To explore the alteration of protein kinase C activity and the effect of aminoguanidine on diabetic glomerulopathy in streptozocininduced diabetic rats.

目的:研究糖尿病大鼠肾脏蛋白激酶C(protein kinase C,PKC)活性变化,探讨氨基胍对糖尿病大鼠肾脏的保护作用及其机制。

HMF in ZXTMN group were lower than in aminoguanidine group.

止消通脉宁有阻断肾脏组织非酶糖基化的作用,而对5-HMF的作用优于氨基胍

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