氨基喹啉

Our chief products include as follows: 5-Nitro-8-hydroxy Quinoline, 8-Aminoquinaldine, 8-Hydroxyquinoline Sulfate, 5,7-Dichloro-8-hydroxyquinaldine, 5-Nitro-0-cresol, 6-Nitro-m-cresol, 2'-Chloroacetophenone, 4-Methyl-5-thiazole ethanol, 4-Aminophenethyl alsohol.

主要产品有：硝羟喹啉，8-氨基喹啉，8-羟基喹啉硫酸盐，8-羟基喹哪啶，5，7-二氯-8-羟基喹哪啶，5-硝基邻甲酚，6-硝基间甲酚，邻氯笨乙酮，4-氨基笨乙醇，4-甲基-5-噻唑乙醇，3-羟基吡啶等。

Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯－4-硝基苯酚和2-氯甲基吡啶为起始原料，经醚化、硝基还原得到3-氯－4-（吡啶－2-甲氧基）苯胺，3-氯－4-（吡啶－2-甲氧基）苯胺与3-氰基－6-乙酰氨基－7-乙氧基－4-氯喹啉反应得到3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉，3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉去乙酰保护基后，与-4-二甲氨基－2-丁烯酰氯经酰化反应得到ner-atinib。

The condensation of 3 carbethoxy isoquinol 4 one with carbamidine, amidine, carbamide and sulfocarbamide gave isoquinolo pyrimidine derivatives, respectively and isoquinolo quinoline derivatives were synthesized by the reaction of o aminobenzaldehyde or o aminopiperonal with isoquinol 4 one.

报道了利用 3 乙氧甲酰基异喹啉 4 酮分别与胍、脒、脲及硫脲类化合物缩合反应合成异喹啉并嘧啶衍生物，邻氨基苯甲醛、邻氨基胡椒醛分别与异喹啉 4 酮反应合成异喹啉并喹啉化合物。6个新化合物的结构通过元素分析、红外光谱、核磁共振氢谱和质谱予以证

Aminoquinoline is one of the most prominence, its beneficial effects in the management of malaria caused huge attention in the pharmacologic research. The first antimalarial for clinic use was stem from AQ, since then, plenty of new structures with higher effect have been discovered.

氨基喹啉类衍生物是其中最为显著的一种，在对抗疟疾药物的研究中受到极大关注并最早应用于临床，多年来对其深入研究也涌现了一批更高效的新结构。

A method for separation and determination of amino acids using pre column derivatization with 6 aminoquinoline N hydroxysuccinimido carbamate AccQ.

对Waters公司采用 6 氨基喹啉 N 羟基琥珀酰亚胺基氨基甲酸酯柱前衍生化测定氨基酸的方法进行了改进。

Fluorometric Determination of Trace Copper with A New Fluorescent Reagent 5-(4-Fluorophenylazo)-8-Salicylidene Aminoquinoline.

新型荧光试剂 5-(4-氯苯偶氮)-8-水杨醛缩氨基喹啉的合成及荧光性质。安徽师范大学学报， 2001，24(4)，353-355

The reaction mechanism was studied and the proposed methods were applied to the determination of SOD activity.Second, baded on sodium terephthalate trapping HO, an automated spectrofluorimetry for determining HO with flow injection analysis was developed. It was applied to the anti-oxidation determination of maize pollen polysaccharose and natural foods.

一设计合成了两种用于超氧阴离子自由基识别检测的荧光探针——香草醛缩-8-氨基喹啉和2-吡啶甲醛苯并噻唑啉，用普通荧光法和流动注射荧光法对超氧阴离子自由基进行分析测定，研究了反应机理，并将其用于超氧阴离子自由基和超氧化物歧化酶活性的测定。

Four hemicyanine derivatives,-N-(4-sulfobutyl)-4-[2-(4-N,N-dimethylamino-phenyl) etheny1] pyridinium (P1),-N-(4-sulfobutyl)-4-[2-(4-N,N-dimethylaminophenyl)-1,3-buteny1] pyridinium (P2),-N-(4-sulfobutyl)-4-2-(4-N,N-dimethylaminophenyl) ethenyll quinolinium (Q1) and-N-(4-sulfobutyl)-4-

合成了具有不同共轭链长度的吡啶盐类及喹啉盐类半菁染料-N-（4-磺酸丁基）-4-[2-4-N，N-二甲基氨基苯基）乙烯基]吡啶鎓盐(P1、-N-（4-磺酸丁基）-4-[2-4-N，N-二甲基氨基苯基）丁二烯基]吡啶鎓盐(P2、-N-（4-磺酸丁基）-4-[2-(4-N，N-二甲基氨基苯基)乙烯基]哇琳鎓盐(Q1)以及-N-（4-磺酸丁基）-4-[2-4-N，N-二甲基氨基苯基丁二烯基]喹啉鎓盐(Q2)。研究了它们的光物理性质，并将它们用作TiO2纳米晶电极的光敏化剂引入光电化学电池。

The determination of amino acids in blood clam antianaemia oral liquid using HPLC-AccQ-Tag method is reported. The oral liquid reacted with 6-aminoquinolyl-N-hydroxysuccini-mdyl carbamate. Then, the corresponding derivatives were analyzed with an HPLC. The chromatographic conditions were AccQ-TagTM C18 column for amino acids analysis (3.9mm×15cm); mobile phase of program elution sodium acetate solution(pH5.02), acetonitrile, Milli-Q water. The amino acids'AQC deriatives were detected at 248nm with a UV-detector. Eighteen kinds of amino acids were completely determined in 35 minutes.

以6-氨基喹啉-N-羟基琥珀酰亚胺基氨基甲酸酯为衍生剂，与毛蚶抗贫血口服液中的氨基酸柱前定量衍生，用WatersHPLC仪，AccQ-TagTM专用C18柱(3.9mm×15cm)，以140mmol·L-1的醋酸钠溶液(pH5.02)为溶剂A，乙腈为溶剂B，超纯水为溶剂C，进行梯度洗脱，检测波长为248nm，35min测试完毕。

Methods The amino acids in the injections were pretreated with 6-aminoquinolyl-N-hydroxysuccinimdyl separately and their derivatives were analyzed on Waters 2695 HPLC using AccQ-Tag column. Gradient eluents consisted of sodium acetate solution (pH 4.95), acetonitrile and water. The Detection wavelength was 248 nm and column temperature 37℃.

采用AccQ-Tag法，以6-氨基喹啉－N-羟基琥珀酰亚胺基甲酸酯为衍生试剂，与复方氨基酸注射液(18AA-V)中17种氨基酸柱前衍生，用Waters 2695 HPLC仪器，AccQ-Tag柱，以醋酸钠(pH 4.95)缓冲液为流动相A，乙腈为流动相B，水为流动相C进行梯度洗脱，检测波长为248 nm，柱温为37℃，进样量为5μL。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。