氨基化合物

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

In this paper, we designed and synthesized a molecule of compound 1, 2-(benzooxazol-2-yl)-5-4-(3-(benzothiazol-2-yl) phenylamino-6--1,3,5-triazin-2-ylaminophenol, which can only assembled into an organogel upon a short irradiation with ultrasound in toluene-methanol mixed solvent. DSC, XRD and IR were used to detect the properties and mechanisms of the organogel.

本论文中，我们设计合成了一个有机小分子化合物1，4-氨基（2-羟基苯基）苯并噁唑3-氨基苯基苯并噻唑二辛基胺缩三聚氯嗪，研究发现，在甲苯/甲醇=1：2的混合溶剂中，只有利用超声才能使之形成凝胶，加热冷却的方法不能形成凝胶，而形成针状结晶。

Two novel pyrazolone derivatives 2-ethylamino-6H-5-(1-phenyl-3-methyl/phenyl-5-pyrazolone-4-ylene)-1,3,4-thiadiazine (PMCP-ETSC/DPCP-ETSC) containing NNS six-membered heterocycles were synthesized by the condensation reaction of 1-phenyl-3-methyl/phenyl-4-chloroacetyl-pyrazolone-5 with 4-ethyithiosemicarbazide. The title compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and single-crystal X-ray diffraction.

利用1-苯基－3-甲基／苯基－4-氯乙酰基－吡唑啉酮－5与4-乙基氨基硫脲发生缩合反应，生成了2个新的双杂环化合物2-乙氨基－6H-5-（1-苯基－3-甲基／苯基－5-吡唑啉酮－4-基）－1，3，4-噻二嗪(PMCP-ETSC/DPCP-ETSC)，并对其进行元素分析、红外光谱、核磁共振表征和晶体结构分析。

The a-amino groups of amino acids react reversibly with aldehydes to form a variety of compounds, each of which is called a Schiff's base.

氨基的α氨基与醛反应是可逆的，可形成多种化合物，每一种都叫希夫碱。

On the basis of previous work in our laboratory, several novel thiosemicarbazones and semicarbazone compounds containing pyrazolone-ring have been synthesized.

本文在实验室原有工作的基础上，合成了以吡唑啉酮环为变色主体的缩氨基脲、氨基硫脲类有机光致变色化合物，通过对固态光致变色性质和晶体结构的研究，深入分析了它们的变色机理，并总结了光致变色性质与之间结构的关系。

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C-,-O-C-,-NR8-C-,-O-C1-6alkanediyl-C-,-NR8-C1-6alkanediyl-C-,-S2-,-O-S2-,-NR8-S2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC, carboxyl, aminoC, mono- or di(C1-4alkyl)aminoC, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; R5 and R6 are H or C1-6alkyl.

本发明涉及右式化合物其N-氧化物、盐、立体异构形式、外消旋混合物、前药、酯及代谢物，其中R 1 及R 8 各是氢、C 1-6 烷基、C 2-6 烯基、C 3-7 环烷基、芳基、Het 1 、Het 2 ；R 1 也可以是式(R 11a R 11b )NC(R 10A R 10b )CR 9 -之基；t是0、1或2；R 2 是氢或C 1-6 烷基；L是-C-、-O-C-、-NR 8 -C-、-O-C 1-6 烷二基-C-、-NR 8 -C 1-6 烷二基-C-、-S 2 -，-O-S 2 -、-NR 8 -S 2 -；R 3 是C 1-6 烷基、芳基、C 3-7 环烷基、C 3-7 环烷基C 1-4 烷基或芳基C 1-4 烷基；R 4 是氢、C 1-4 烷基OC、羧基、氨基C、一-或二(C 1-4 烷基)氨基C、C 3-7 环烷基、C 2-6 烯基、C 2-6 炔基或任选被取代的C 1-6 烷基；R 5 及R 6 是氢或C 1-6 烷基。

All of the tripodal schiff base ligands and their complexes were characterized.

以三乙醇胺、巯基苯胺、巯基乙胺为初始原料，设计合成了六个三脚架结构的化合物，其合成路线如下：三乙醇胺与氯化亚砜反应得到三(2-氯乙基)胺(1)，然后与巯基苯胺或巯基乙胺在碱性条件下反应生成三脚架结构的三{[2-(2-氨基苯基)硫代]乙基}胺(2)或三{[2-(2-氨基乙基)硫代]乙基}胺(3)，然后再与水杨醛、2-甲酰基-8-羟基喹啉(8)、2-甲酰基-8-苄氧基喹啉(7)反应得到六种新型的含硫西佛碱化合

Owing to different structures of cotton fiber and chitin fiber ,they have different adsorbability to reactive dyestuffs.

采用不同的醛类化合物对甲壳素纤维上的氨基进行保护，活性染料染色后用稀酸脱去氨基的保护基。

With TEMPO(5 mol%) as the catalyst,N-methyl-N-phenyl-hydrazine(1.2 equiv.) as the amine source,the direct ortho-amination of 2-naphthols could be easily achieved.The reaction was carried out at room temperature under air atmosphere.

以5 mol%TEMPO为催化剂，1.2当量N-甲基-N-苯基肼作氨源，二氯甲烷为溶剂，空气中，室温下，实现了对2-萘酚邻位氨基化，可以高效的合成1-氨基-2-萘酚类化合物。

With TEMPO(5 mol%) as the catalyst,N-methyl-N-phenyl-hydrazine(1.2 equiv.) as the amine source,the direct ortho-amination of 2-naphthols could be easily achieved.

以5 mol%TEMPO为催化剂，1.2当量N-甲基-N-苯基肼作氨源，二氯甲烷为溶剂，空气中，室温下，实现了对2-萘酚邻位氨基化，可以高效的合成1-氨基-2-萘酚类化合物。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了