氨基化合物

A novel isomer of furazano energetic compound 3,4-diaminofurazanofuroxan was synthesized by the dimeric ring-close reaction of transitional intermediate 3-amino-4-cyanofurazan oxide after the energetic compound 3-amino-4-chloroximinofurazan was treated with diluent alkali at low temperature, The yield of DAFF isomer could be over 66.3% and its single crystal was cultivated.

将含能化合物3-氨基－4-氯肟基呋咱在低温下用稀碱处理后发生过渡中间体3-氨基－4-氰基呋咱氧化物的二聚关环反应合成了新型呋咱类含能化合物3，4-二氨基呋咱基氧化呋咱异构体，产率达66.3%。

The synthesis process comprises using chiral phosphorus acid as catalysis, synthesizing 2-(4, 7-indoline) compound in high efficiency and highly enantioselective by using sulfur imide and 4, 7-indoline compound, and products can be used to prepare several 2-dimethylamino indoline compounds with high optical activity through oxidation reaction.

以手性磷酸作为催化剂，由磺酰亚胺和4，7-二氢吲哚化合物可以高效率高对映选择性的合成2-甲氨基(4，7-二氢吲哚)化合物；产物可以经过氧化反应用于制备多种高光学活性的2-甲氨基吲哚化合化合物。

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Diamino-3,5-dinitropyridine and 2,6-diamino-3,5-dinitropyridine-1-oxide was reacted with aqueous ammonia and KMnO4 under different conditions. Substitutions in the 4 position to the nitro group were obtained with high yields: 2,4,6-triamino-3,5-dinitropyridine (81.5%) and 2,4,6-triamino-3,5-dinitropyridine-1-oxide (85.4%).

以氨水为胺化剂，KMnO4为氧化剂，在不同反应条件下实现2，6-二氨基-3，5-二硝基吡啶和2，6-二氨基-3，5-二硝基吡啶-1-氧化物4位的氧化胺化反应，目标化合物2，4，6-三氨基-3，5-二硝基吡啶和2，4，6-三氨基-3，5-二硝基吡啶-1-氧化物的收率分别达到81.5%和85.4%。

The compounds are represented by the structural Formula 1, Chemical formula should be inderted here as it appears on the abstract in paper form. a prodrug thereof, or any pharmaceutically acceptable salt, solvate, isomer or racemic mixture of the compound or said prodrug wherein R1 is heteroaryl, N-arylaminocarbonyl, N-heteroarylaminocarbonyl, benzimidazolyl or benzothiazolyl; R15 is present or not and if present is H, aryl, alkyl, arylalky or heteroarylalkyl; A is aryl, heteroaryl, cycloalkyl, cycloalkylidene, heterocycloalkylidene or heterocycloalkyl wherein said aryl, heteroaryl, cycloalkyl, cycloalkylidene, heterocycloalkylidene and heterocycloalkyl moieties may be substituted or unsubstituted; and B, L, X and R18 are defined herein.

所述化合物用结构式1表示，包括其前药或所述化合物或所述前药的任何药学上可接受的盐、溶剂合物、异构体或外消旋混合物，其中R 1 为杂芳基、N-芳基氨基羰基、N-杂芳基氨基羰基、苯并咪唑基或苯并噻唑基；R 15 存在或不存在，如果存在，则为H、芳基、烷基、芳基烷基或杂芳基烷基；A为芳基、杂芳基、环烷基、环烷叉基、杂环烷叉基或杂环烷基，其中所述芳基、杂芳基、环烷基、环烷叉基、杂环烷叉基和杂环烷基部分可被取代或未被取代；B、L、X和R 18 如说明书所定义。

The condensation of 3 carbethoxy isoquinol 4 one with carbamidine, amidine, carbamide and sulfocarbamide gave isoquinolo pyrimidine derivatives, respectively and isoquinolo quinoline derivatives were synthesized by the reaction of o aminobenzaldehyde or o aminopiperonal with isoquinol 4 one.

报道了利用 3 乙氧甲酰基异喹啉 4 酮分别与胍、脒、脲及硫脲类化合物缩合反应合成异喹啉并嘧啶衍生物，邻氨基苯甲醛、邻氨基胡椒醛分别与异喹啉 4 酮反应合成异喹啉并喹啉化合物。6个新化合物的结构通过元素分析、红外光谱、核磁共振氢谱和质谱予以证

In this method, blue-violet compound formed through reaction between amido and nihydrin hydrate can be detected at 570nm wavelength, and its content is proportional to the peak area. This method is easy to use, sensitive, and saving time. Its average recovery is 98.4%, and relative standard deviation is 1.0%.

试验主要利用氨基酸的氨基与茚三酮水合物反应可生成蓝紫色化合物，该化合物最大吸收峰在570nm波长处，且此吸收峰值的大小与氨基酸释放出的氨基成正比，因此可作为氨基酸定量分析方法。

In the first part, five new 4-acyl pyrazolone 4-ethyl-thiosemicarbazones compounds: 1-Phenyl-3-methyl-4-(4-bromo)benzal-pyrazol-5-one N(4)-ethyl-thiosemicarbazone (PM4Br BP-ETSC), 1-Phenyl-3-methyl-4-(4-methyl)benzal-pyrazol-5-one N(4)-ethyl-thiosemicarbaz -one (PM4MBP-ETSC), 1-Phenyl-3-methyl-4-benzal-pyrazol-5-one N(4)-ethyl-thiosemicarba -zone, 1,3-diphenyl-4-benzal-pyrazol-5-one N(4)-ethyl-thiosemicarbazone and 1-Phenyl-3-methyl-4-phenylacetyl-pyrazol-5-one N(4)-ethyl-thiosemi -carbazone have been synthesized and characterized by elemental analyses, IR, 1H NMR spectra and single-crystal XRD.

第一部分合成了五个4-酰基吡唑啉酮缩4-乙基-氨基硫脲化合物：1-苯基-3-甲基-4-（4-溴）苯甲酰基-5-吡唑啉酮缩4-乙基-氨基硫脲(PM4BrBP-ETSC)，1-苯基-3-甲基-4-(4-甲基)苯甲酰基-5-吡唑啉酮缩4-乙基-氨基硫脲(PM4MBP-ETSC)，1-苯基-3-甲基-4-苯甲酰基-5-吡唑啉酮缩4-乙基-氨基硫脲，1，3-二苯基-4-苯甲酰基-5-吡唑啉酮缩4-乙基-氨基硫脲和1-苯基-3-甲基-4-苯乙酰基-5-吡唑啉酮缩4-乙基-氨基硫脲，其中前四个具有光致变色性质。

Synthesis and structural characterization of novel cycioplatinated complexes with 2-aryl imidazolines 2-arylimidazoline ligands 2a-2d were synthesized from benzoyl chloride or p-methoxybenzoyl chloride with aminoethanol or valinol and 2e was synthesized from 2-phenylimidazoline.

新型2-芳基咪唑啉环铂化合物的合成与结构表征以苯甲酰氯或4-甲氧基苯甲酰氯和氨基醇(2-氨基乙醇或外消旋的缬氨基醇)为原料，合成了四种2-芳基咪唑啉配体2a-2d，以2-苯基咪唑啉为原料合成了配体2e，其中2d为新化合物。

Methods Synthesis 3-O-carbamylnoviose and 3-acetamido-7-hydroxycoumarin, compare the activity of inhibit K562 cell with novobiocin by MTT.

合成新生霉素的结构单元3-O-氨基甲酰基诺维糖（化合物2）和3-乙酰氨基-7-羟基香豆素（化合物3），MTT法测定两化合物与新生霉素抗K562细胞的活性。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。