氨基化

We investigated constituent of triterpenoid saponins ofAlbizzia, two new compounds together with two known compounds were isolated from Albizzia julibrissin Durazz. by using column chromatography (macroreticular resin, silica gel, Sephadex gel, reverse phase silica gel),preparative HPLC methods et al.On the basis of spectroscopic analysis, including IR,ESI-MS,~1H-NMR,~(13)C-NMR,HMBC,HMQC,~1H-~1HCOSY and chemical methods, the structure of two new compounds were identified as 3 - O -[β-D-xylopyranosyl(1→2)-β-D-fucopyranosyl (1→6)-β- D -2- deoxy - 2 - acetoamidoglucopyranosyl] -21-O-[(6S)-2- trans- 2,6-dimethyl - 6 - O-β- D - quinovopyranosyl -2,7- octadienoyl] - acacic acid- 28 - O-β-D-glucopyranosyl(1→3)[α-L-arabinofuranosyl(1→4)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside acacic acid 3- O -β- D- glucopyranosy(1→3)-β- D- fucopyranosl(1→6) [β-D- xylopyranosyl (1→2)]-β-D-glucopyranoside ;two known compounds were acacic acid lactone 3- O -β-D- xylopyranosyl-(1→2)-β-D-fucopyranosl (1→6)- 2-deoxy -2 -acetoamido -β-D- glucopyranoside ; acacic acid lactone 3- O-β-D-xylopyranosyl(1→2)-α-L- arabinopyranosl (1→6)- 2- deoxy - 2- acetoamido -β-D-glucopyranoside . The study lays chemical foundation and chemical reference substance for enhancing quality standard of Albizzia julibrissin Durazz.

本研究论文在综述国内外对合欢属Albizzia三萜皂苷化学成分和药理作用研究进展的基础上，利用传统植化分离手段和现代分离技术，包括大孔树脂、硅胶、葡聚糖凝胶、反相硅胶等柱色谱，制备高效液相色谱法等技术从中药合欢皮中分离得到了4个化合物，其中，2个新化合物和2个己知化合物，并进一步通过现代分析技术IR，ESI-MS，~1H-NMR，~(13C-NMR，HMBC，HMQC，~1H-~1HCOSY等和化学方法鉴定了2个新化合物的结构分别是：3-O-[β-D-吡喃木糖基(1→2)-β-D-吡喃夫糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖基]-21-O-[(6S)-2-反式-2，6-二甲基-6-O-β-D-吡喃鸡纳糖基-2，7-辛二烯酸基]-金合欢酸-28-O-α-L-呋喃阿拉伯糖基(1→4)[β-D-吡喃葡萄糖基(1→3)]-α-L-吡喃鼠李糖基(1→2)-β-D-吡喃葡萄糖苷，金合欢酸3-O-β-D-吡喃葡萄糖基(1→3)-β-D-吡喃夫糖基(1→6)[β-D-吡喃木糖基(1→2)]-β-D-吡喃葡萄糖苷；2个已知化合物结构分别是：金和欢酸内酯3-O-β-D-吡喃木糖基(1→2)-β-D-吡喃夫糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖苷，金和欢酸内酯3-O-β-D-吡喃木糖基(1→2)-α-L-吡喃阿拉伯糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖苷。

In our paper,1-hexylcarbamoyl-5-fluorouracils and1-cyclohexyl-carbamoyl-5-fluorouracils were prepared through 5-fluorouracil reacting with hexyl isocyanate or cyclohexyl isocyanate by using dimethylaminopyridine as the catalyst.

以5-氟尿嘧啶(5-FU)、正己基异氰酸酯和环己基异氰酸酯为原料，在N，N-二甲氨基吡啶的催化下，通过N-脲化反应制成1-己基氨基甲酰基-5-氟尿嘧啶及1-环己基氨基甲酰基-5-氟尿嘧啶。

The copolycondesation type polyamic acid was synthesized by using pyromellitic dianhydride and 3,3',4,4'-benzophenonetetracarboxylic dianhydride as the dianhydride monomers, 4,4'-diamino diphenylmethane and 4,4'-oxydianiline as the diamine monomers under microwave irradiation in dimethylformamide.

在N，N'-二甲基甲酰胺溶剂中，以均苯四甲酸酐和3，3'，4，4'-二苯酮羧酸二酐为二酐单体，4，4'-二氨基二苯醚和4，4'-二氨基二苯甲烷为二胺单体，采用微波辐射低温溶液共缩聚，合成了聚酰胺酸预聚体，然后亚胺化脱水、环化，生成共缩聚聚酰亚胺。

Racemic backbones 2-amino-2'-hydroxy-6,6'-dimethyl-l,l'-biphenyl la and 2-amino-2'-hydroxy-4,4',6,6'-tetramethyl-l,1'-biphenyl 1b were synthesized from o-methylaniline and 2,4-dimethylaniline via nitration, diazotation/iodination, Ullmann coupling, selective reduction, diazotation/hydrolysis and hydrogenation.

从邻甲苯胺及2，4-二甲基苯胺出发，经过硝化，重氮化-碘代，偶联，单还原，重氮化-水解及还原反应合成了消旋体骨架2-氨基-2'-羟基-6，6'-二甲基-1，1'-联苯1a和2-氨基-2'-羟基-4，4'，6，6'-四甲基-1，1'-联苯1b。

In the second section, with ketone and hydroxylamine hydrochloride as the starting materials, 3-aminopropanol is prepared via three steps including reaction of ketone and hydroxylamine hydrochloride , condensation of ketoxime and acrylonitrile, and hydrogenation cracking of condensation product.

第二是3-氨基丙醇的制备，由酮肟丙烯睛缩合物催化氢化裂解制得：即先以酮、盐酸羟胺为起始原料在碱性条件下合成酮肟，再与丙烯腈反应生成酮肟丙烯腈缩合物后经催化氢化裂解制得3-氨基丙醇。

On the basis of these principles and requirements,in this paper,a new modifier has been synthesized from pyromellitic dianhydride and thiosemicarbazide by the nucleophilic addition of anhydride,the cyclization of acyl thiosemicarbazide in alkaline solution,and the N-hydroxymethylation of the triazole-thione.

本文根据这一思路，以均苯四甲酸二酐和氨基硫脲为起始原料，通过酸酐的亲核加成反应、酰氨基硫脲的碱性环化反应、三唑硫酮环的N-羟甲基化反应合成出了一种新的N-羟甲基三唑硫酮酸改性剂。

Bezaldehyde was used as protective agent in first method.S-Epichloeohydrin was aminated and acidulated to give(2S)-1-Amino-3-chloro-propanol Salts.The acetylation of (2S)-1-Amino-3-chloro-propanol by acetic anhydride produced the intermediate-N-[2--3-chloropropyl]acetamide.And then at 20℃,in the presence of lithium tert-butoxide,benzyl 3-fluoro-4-morpholinophenyl carbamate react with-N-[2--3-chloropropyl]acetamide to give linezolid in total yield of 43.6%.

路线一采用苯甲醛作保护剂，使S-环氧氯丙烷氨解、酸化生成S-1-氨基-3-氯-2-丙醇盐酸盐，然后经乙酰化反应后，生成中间体-N-[2-乙酰氧基-3-氯丙基]乙酰胺，再用N-(3-氟-4-吗啉苯基)氨基甲酸苄酯和中间体在催化剂叔丁醇锂存在下25℃反应生成利奈唑酮，总产率达到43.6%。

Firstly, the 10-methoxy-5H-dibenzazepine is synthesized through brominating and methoxylation and hydrolyzation from 5H-dibenzb, fJazepine-5-carbonyl chloride.

首先，研究了以5-氯甲酰基亚氨基芪为原料，经溴化、甲氧基化、水解合成了10-甲氧基亚氨基芪。

Serum alt, ast, bile acid and albumin levels were measured with automatic biochemistry analysator during the procedure.

采用ccl4造模，全自动生化分析仪检测血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、胆汁酸及白蛋白水平；he染色和vg染色观察肝脏病理及纤维化面积的变化，分析黄芪对肝功能及肝纤维化形成的影响。

The kinetic approach of the substrate reaction during modification of enzyme activity has been applied to a study on the kinetics of the course of inactivation of metal enzyme by metal ion chelator and reactivation of apo-enzyme by metal ion restoration.

应用邹承鲁先生建立的底物反应动力学的理论研究了含金属锌离子的氨基酰化酶在金属螯合剂的作用下去金属失活的动力学研究和去金属失活的氨基酰化酶与金属离子重组恢复活性的动力学过程的研究中。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。