氨基化

Hydroxy-5, 10-dihydrophenophosphazine 10-oxide (1) reacted with SOCl2, and then with MeONa in MeOH to give a methyl phosphinate (2) which can be converted to a dinitro compound 3 (62%) by nitration and the resulting dinitro compound 3 can further be converted to 2, 8-diamino-10-methoxy-5, 10-dihydrophenophosphazine 10-oxide (4, 71%) by hydrogenation over Pd/C (w = 0.05). And the effect of amount of Pd/C (w = 0.05) on the reduction was also studied.

10－羟基－5，10－二氢磷杂吖嗪－10－氧化物（1）经醯氯化、甲基化得到10－甲氧基－5， 10－二氢磷杂吖嗪－10－氧化物（2），2经硝化得到10－甲氧基－2，8－二硝基－5，10－二氢磷杂吖嗪－10－氧化物（3，62%）。3在Pd／C（w = 0.05）存在下，用氢气还原为2，8二氨基－10－甲氧基－5，10－二氢磷杂吖嗪－10－氧化物（4，71%），考察了Pd／C（w = 0.05）用量对氢化还原反应的影响。

Mehods Commercially available glycine ethyl ester hydrochloride was used as starting material to give the target compound via addition, protection with BOC, Dieckmann cyclation, reduction with NaBH4 and LiAlH4, protection, oxidation, oximation and deprotection.

以甘氨酸乙酯盐酸盐为原料，依次经加成、BOC保护氨基、Dieckmann环化、NaBH4还原羰基、LiAlH4还原氰基、BOC保护氨甲基、氧化、肟化、脱BOC保护等9步反应制得目标化合物。

METHOD Dofetilide was synthesized by steps of reaction (substitution ,reduction, methylsulfonylation and methylammoniation, etc) from p-nitrophenol and p-amino phenethyl alcohol.

以对硝基苯酚为起始原料，经取代、还原、甲磺酰化等反应制得 4甲磺酰苯胺(5 )；以对氨基苯乙醇为起始原料，经甲磺酰化、甲氨化等反应制得 4 甲磺酰苯胺(8)，再与5经取代反应制得多非利特。

Polyimide/silica (PI/SiO2) nano-hybrid films of different solid content were prepared based on pyromellitic dianhydride and 4, 4'-oxydianiline using tetraethoxysilane as the inorganic precursors.

以均苯四甲酸二酐和4，4'-二氨基二苯醚为有机单体，正硅酸乙酯为无机前驱体，制备了SiO2含量一定，PAA杂化胶液固体含量不同的PI/SiO2纳米杂化薄膜。

Synthesizc 2-methyl-5-acetamino benzene sulfochloride using p-toluidine primer reactant by aceylation and chlorosulfonation.

以对甲基苯胺为起始原料，通过乙酰化和氯磺化反应合成2-甲基－5-乙酰氨基苯磺酰氯。

The reaction can be carried out in a non-aqueous solution and 4-aminopyridine can be diazotized with this method.

这个方法表现出如下优点：1），整个重氮化与偶联反应均在非水溶剂中进行；2），改变原料不同投料比，可以分别得到含有一，二，四偶联产物为主的反应产物；3），可以合成在酸性水溶液中不易重氮化的4-氨基吡啶的偶氮化合物。

This paper reviews the kinetic mechanism of acetylcholinesterase, illustrates the principle and application of the kinetic parameters such as Michealis-Menten affinity constant Km, maximum reaction velocity Vmax, turnover number Kcat, bimolecular rate constant Ki, affinity constant of the inhibitor for the a ctive site Ka, phosphorylation or carbamylation rate constant K2, and discusses the potential practical application benefiting from the study of the kinetic analysis.

综合评述了AChE的动力学机制的发展状况，着重介绍了米氏常数Km、最大反应速率Vmax、转换率Kcat、双分子速率常数Ki、抑制剂化合物对AChE活性部位的亲和力常数Ka、磷酸化或氨基甲酸化速率常数K2，这些动力学参数的原理及其应用状况，探寻了动力学机制将带来的实际应用。

The nano-ionic liquid containing metal complex could be an effective catalyst for oxidative carbonylation of amines to carbamates and disubstituted ureas and for synthesis of unsymmetric ureas from amines and nitrobenzene, in which turn over frequencies exceeded 10000mol/mol/h.

以该系列纳米离子液体为催化剂高效的实现了胺类化合物催化氧化羰化制备氨基甲酸酯和二取代脲（转化频率＞10000mol/mol/h）以及胺与硝基苯通过一氧化碳羰化制备不对称脲的过程。

It was shown that the absorption peaks of amine and amide groups of gelatin were shifted in HDPE/PE-g-MAH/Gelatin blends because of the reaction of PE-g-MAH with gelatin. The addition of PE-g-MAH made the increase of HDPE glass transition temperature. The compatibilizing effect of PE-g-MAH was due to the crystal compatibility produced by forming the co-crystals of HDPE, PE-g-MAH and PE-g-MAH-g-gelatin. The blends of EAA and gelatin were prepared by melting process and the compatibility of the blends was also studied.

红外光谱分析结果表明：体系中明胶的氨基吸收峰、酰胺Ⅱ带吸收峰峰位发生了明显的变化；二甲苯和水抽提实验表明，在熔融共混过程中EAA与明胶发生了反应；DMA测试共混物的玻璃化转变温度发现：两组分的玻璃化转变温度差值减小；SEM的实验结果表明，共混物中明胶的表面有接枝物形成。

The blends of PE-g-MAH and gelatin were prepared by melting process and the compatibility of PE-g-MAH and gelatin in blends were characterized. The results of FTIR showed that the characteristic absorption band peaks of amine and amide groups of gelatin were shifted in PE-g-MAH/Gelatin blends, the equilibrium values of torque were higher with the increase of blending temperature, which proved that graft copolymer PE-g-MAH-g-gelatin was formed during the preparation process, and the amount of PE-g-MAH-g-gelatin was increased with increasing the amount of PE-g-MAH. SEM micrographs exhibited that there was PE-g-MAH-g-gelatin formed in surface of gelatin phase.

通过红外光谱分析、HAAKE流变分析、抽提等实验证明：共混物中明胶的氨基、酰胺基团吸收峰峰位发生了明显的变化；在熔融共混过程中，随着温度的提高，平衡扭矩增大；明胶与PE-g-MAH发生了反应形成PE-g-MAH-g-明胶接枝共聚物，而且随着PE-g-MAH用量的增加，形成接枝共聚物的量也提高；SEM的实验结果表明，在明胶的表面确有接枝物形成；通过DMA测试共混物的玻璃化转变温度，发现两组分的玻璃化转变温度差值减小，二者的相容性提高，实现了共混体系的自增容。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。