氨基乙酰

Study on the Crystallization Process of Labeled GL-7-ACA Acylase CA130 Complex 7β-bromoacetyl amino cephalosporanic acid (BA-7-ACA), an analog of glutaryl-7-amino cephalosporanic acid (GL-7-ACA), can inhibit and specifically alkylate GL-7-ACA acylase (CA130) from Pseudomonas sp. 130, forming a carbon-carbon bond between BA-7-ACA and the C-2 on indole ring of Trp-β4 residue of CA130.Here we reported that BA-7-ACA labeled CA130 (BA-C130) could self-catalyze the hydrolysis of BA-7-ACA during crystallization process. The hydrolysis was confirmed to be a reaction analogous to the one of GL-7-ACA by comparative MALDI-TOF (matrix-assisted laser desorption/ionization-time of flight) spectrometry analysis.

二、GL-7-AcA酰化酶CA130标记复合物的结晶过程研究溴乙酰氨基头孢烷酸（7β-bromoacetyl amino cephalosporanic acid，BA-7-ACA）作为戊二酰-7-氨基头孢烷酸（GL-7-ACA）的类似物，不仅能够抑制GL-7-ACA酰化酶CA130的活力，而且能通过在BA-7-ACA和CA130的β亚基第四位色氨酸吲哚环二位碳原子之间形成碳-碳共价键而将CA130特异的烷基化。

The effects of above-mentionedconditions on alkylene reaction are studied to obtain the optimum reactive conditionsby orthogonal experiments having seven factors and three levels. GCLE is chosen as material to prepare 7-phenyl acetamideyl vinyl cephalkyl acidp-methoxy benyl eatsr in the experiment. The process is as follow: GCLE reacts withiodide in solvent, and produce 3-iodid, then reacts with PPh_3 to produce Witting agent,and reacts with HCHO to produce 7-phenyl acetamideyl vinyl cephalkyl acid p-methoxy benyl eatsr in alkaline conditions.

试验选用GCLE作为原料制备7-苯乙酰氨基-3-乙烯基头孢烷酸对甲氧苄酯，反应过程如下：GCLE与碘化物、PPh3在溶剂中反应生成3位膦盐，在碱性条件下生成Wittig试剂再与HCHO反应生成7-苯乙酰氨基-3-乙烯基头孢烷酸对甲氧苄酯。

NatA is one of the N-terminal acetytransferases in yeast. It is composed of two subunits, NAT1 and ARD1. Defect in one of them leads to loss of activity of NatA.

对酿酒酵母的研究揭示了 3种不同的N末端乙酰基转移酶NatA、NatB、和NatC ，它们将乙酰CoA的乙酰基团转移到蛋白质N末端残基的α氨基上。

No interference was found with conventional drugs, except vancomycin and methylprednisolone. The average concentrations of phenacetin and paracetarnol were (5.94 ± 4.79) and (8.81 ± 2.91)μg/mL in serum,(3.25 ± 1.10) and (570.45 ± 187.13)μg/mL in urine in the 13 healthy volunteers.

除万古霉素和甲泼尼龙外，其他临床常用药物对测定无干扰。13名健康受试者血清中非那西丁和总对乙酰氨基酚浓度为(5.94±4.79)和(8.81±2.91)μg/mL；尿液中非那西丁和总对乙酰氨基酚浓度为(3.25±1.10)和(570.45±187.13)μg/mL。

Naphthalene acetyl chloride was prepared firstly by the reaction betweenα-naphthylacetic acid and SOCl2 in anhydrous benzene, then reacted with potassium thiocyanate to obtainα-naphthalene acetyl isosulfocyanate, as taking an addition reaction with p-chloro benzoyl hydrazine the novel compound N-naphthalene acetyl-N'-p-chloro benzoylamino thiocarbamide was finally synthesized.

通过α-萘乙酸和SOCl2在无水苯中反应制得α-萘乙酰氯，然后与硫氰酸钾反应生成α-萘乙酸基异硫氰酸酯，再与对氯苯甲酰肼进行加成反应，生成新型化合物N-萘乙酰基－N'-对氯苯甲酰氨基硫脲。

After basal anesthesia, ilioinguinal/iliohypogastric nerve blockades was administed in nerve block group, paracetamol group received rectal paracetamol, control group had not any medication.

各组患儿行基础麻醉后，神经阻滞组行患侧髂腹股沟／髂腹下神经阻滞；对乙酰氨基酚组经肛门塞人直肠对乙酰氨基酚栓剂；对照组未予任何药物镇痛。

The yield reached 67.0% The medicinal and pesticidal activities of a part of the compounds have been measured .

在进行氨基酰化时，论文克服了该类嘧啶环上4位氨基在常规条件下不与芳香类和带有强吸电子基如三氯乙酰基酰化试剂发生反应的困难，通过采用在强碱性条件下进行酰化，得以成功。

Tris-(1-aziridinyl)- phosphine oxide and 2-[bis-(2-chloroethyl)-amino]-tetrahydro-1, 3, 2-oxazaphospholidine-2-oxide(Ⅲ, B-518) possess inhibitory action against a variety of animal tumours and have been used clinically. Recently, bis-(1-aziridinyl)-phosphinyl carbamic acid ethyl ester(Ⅱ, AB-100) was found to possess significant activity with low toxicity on experimental animal tumours.

双(2-氯乙基)氨基磷酰二氯与乙烯亚胺在脱水苯或对氧六环中并在三乙胺的存在下进行缩合，生成N，N-双(2-氯乙基)-N′，N-二乙烯基-磷酰胺；与双巯基或双氨基化合物作用，则生成相应的环状磷酰胺、磷酰胺酯以及磷酰胺硫代酯氮芥类化合物。

Results:paracetamol injection solution of 25% was produced through the study on technology.

结果：本实验通过对乙酰氨基酚的工艺研究生产出了25%的对乙酰氨基酚注射剂。

The quick results cold capsule contains have calculus bovis factitius , pedantic chlorobenzene pain namely agile , caffeine and acetophenetidin aminophenol internally , is that one kind of the people who is not that steroid is similar to analgesic-antipyretic , irritability body constitution is convinced among them to acetophenetidin aminophenol 责任编辑:admin

速效感冒胶囊内含有人工牛黄、酸氯苯即敏、咖啡因和乙酰氨基酚痛，其中对乙酰氨基酚痛是一种非类固醇类解热镇痛药，过敏体质的人服用，可致粒细胞减少，过敏性皮炎；若肾成果减退的病人服用，可致间质性肾炎，以致引起急性肾成果干涸。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。