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On the other hand, the hepatic microsomal aminopyrine demethylase activity was obviously inhibited 2 hours after administration of the same dose of SY-801 and SY-640, while the content of hepatic cytochrome P-450 was not affected.

体外实验表明,SY-801和SY-640对正常小鼠、3-甲基胆蒽(3-MC)处理小鼠及苯巴比妥处理小鼠小鼠肝微粒体氨基比林脱甲基酶活性都具有明显的抑制作用,其中对3-MC处理小鼠肝微粒体氨基比林脱甲基酶活性抑制作用最显著。

In order to study the relation of cytochrome P-450 with the protective action of SY-801 and SY-640 against 〓-induced UDS and 3H-BP binding to nuclear DNA, the effects of SY-801 and SY-640 on liver microsomal cytochrome P-450 were studied in mice. The results indicated that the liver microsomal cytochrome P-450 concentration and aminopyrine demethylase activity were significantly increased in mice pretreated with SY-801 150mg/kg or SY-640 150 mg/kg once daily for three days.

本实验进而观察了SY-801对小鼠肝微粒体细胞色素P-450酶系的影响,结果表明SY-801和SY-640体内连续给药3天,可诱导小鼠肝微粒体细胞色素P-450含量明显增加,同时氨基比林脱甲基酶活性亦明显增加;给药1次2小时内二者均可抑制氨基比林脱甲基酶活性,而对肝微粒体细胞色素P-450含量则无明显影响。

Immunofluorescence confirmed that sweat glands in normal mice did not present gamma-aminobutyric acid receptor subtype GABAA andα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainic acid subtype of glutamate receptor. Mature mice with reactive sweat glands that declined more than 25% compared to baseline were defined as anhidrotic mice.

免疫组织荧光染色未发现在正常小鼠皮肤组织及汗腺的分泌细胞存在γ-氨基丁酸A型(gamma-aminobutyric acid,GABAA)受体α1亚单位、谷氨酸受体亚型α-氨基羟甲基恶唑丙酸(α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid , AMPA )GluR1/2/3/4亚单位和海人酸(kainic acid,KA)受体GluR5/6/7亚单位的表达。

Immunofluorescence confirmed that sweat glands in normal mice did not present gamma-aminobutyric acid receptor subtype GABAA andα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainic acid subtype of glutamate receptor.Mature mice with reactive sweat glands that declined more than 25% compared to baseline were defined as anhidrotic mice.

免疫组织荧光染色未发现在正常小鼠皮肤组织及汗腺的分泌细胞存在γ-氨基丁酸A型(gamma-aminobutyric acid,GABAA)受体α1亚单位、谷氨酸受体亚型α-氨基羟甲基恶唑丙酸α-amino(来源:Ad1d1BC论文网www.abclunwen.com-3-hydroxy-5-methylisoxazole-4-propionic acid , AMPA GluR1/2/3/4亚单位和海人酸(kainic acid,KA)受体GluR5/6/7亚单位的表达。

Based on the possible degradation products, Microbial degradation pathways of metsulfuron-methyl is concluded as follows: after the cleavage of the sulfonylurea bridge, 2-amino-4-methoxy-6-methyl-triazine is demethylated and the annularity reaction of sulphanilamide occurs.

甲磺隆主要降解途径首先是脲桥的断裂,然后6-甲氧基-4-甲基-2-氨基-三氮嗪进一步脱甲基,而磺酰胺类物质将进一步脱氨基环化。

In the first step of thedouble annulation route, 2-amino-3-carbamoyl-5,6-dihydro-4-pyridones 2 werecreated in high to excellent yields by a formal [5C + 1N] annulation reaction ofketene--acetals 1 with ammonia.

第一步,二硫缩烯酮1和氨源通过[5C + 1N]加成反应产率极高的得到了2-氨基-3-氨基甲酰基-5,6-二氢-4-吡啶酮2。

The adsorption isotherms of aminoantipyrine, antipyrine, pyrazolone and the competitive adsorption isotherms of aminoantipyrine and antipyrine on the imprinted stationary phase were determined using rectangular pulse frontal analysis and static method.

并利用前流分析和静态分析法研究了氨基安替比林、安替比林和吡唑酮单组分以及氨基安替比林与安替比林的竞争吸附等温线。

PVC resin, PTFE resin, fumaric acid, anthraquinone, nitroanthraquinone, paraaminophenol, melamine, cyanuric acid, sulfanilic acid, chemical inhibitor 168, azoic coupling component As, stearate, aniline, nitroaniline, pentaerythritol, chlorcosane, sodium calcium, triethylene diamine, sodium benzene sulphinate, m-phthalic acid, thiourea, aniline black dyestuffs, acid dyestuff, etc.

聚氯乙烯树脂、聚四氟乙烯树脂、反丁烯二酸、蒽醌、硝基蒽醌、对氨基苯酚、三聚氰胺、氰尿酸、对氨基苯磺酸、抗氧剂168、色酚As、硬脂酸盐、苯胺、硝基苯胺、双季戊四醇、氯???腊、甲酸钙、三乙烯二胺、苯亚磺酸钠、间苯二甲酸、二甲酯五磺酸钠、硫脲、油溶性苯胺黑染料、酸性黑染料等有机化工原料和中间体。

The compound of 2, 6-Bis (4-aminophenoxy) benzonitrile (26B4APBN) was synthesized through condensation reaction between 4-aminophenol (4AP) and 2, 6-dichlorobenzonitrile.

氨基苯酚和2, 6-二氯苯腈通过缩合反应,合成得到了2, 6-双(4-氨基苯氧基)苯甲腈(26B4APBN)。

The reaction of calcium L-threonate with hydrogen bromide in acetic acid readily yields (2S, 3S)-2, 4 -dibromo-3 -hydroxy butanoic acid which was further converted into methyl (2s, 3S)-2,4-dibromo-3-hydroxybutanoate by treatment of methanol.

在化合物12上引入氨基甲酰基可用二氯磷异氰酸酯、氯乙酰异氰酸酯或氯磺酰异氰酸酯,随之引入的二氯磷酰基、氯乙酰基或氯磺酰基可分别用碳酸氢钠、N-甲基二硫代氨基甲钠或亚硫酸钠脱去。

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