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Alkylamine reaction with dialkyl cyanodithioiminocarbonate was catalyzed by quaternary ammonium salts at room temperature to yield 3-alkylamine-5-amino-1,2,4-triazole in good quality and high yields. After imidization and reaction with an α,β-unsaturated acid derivative, the reaction intermediate was hydrolyzed in the presence of a Lewis acid to obtain the target product.

烷基胺与氰基亚胺硫代二甲酯在季氨盐催化作用下得到质量好、收率高的3-烷氨基-5-氨基-1,2,4-三氮唑,进一步经过亚胺中间体并与α,β-不饱和酸酯作用后,中间产物在Lewis酸催化作用下水解得到三唑嘧啶酮。

Study on the Crystallization Process of Labeled GL-7-ACA Acylase CA130 Complex 7β-bromoacetyl amino cephalosporanic acid (BA-7-ACA), an analog of glutaryl-7-amino cephalosporanic acid (GL-7-ACA), can inhibit and specifically alkylate GL-7-ACA acylase (CA130) from Pseudomonas sp. 130, forming a carbon-carbon bond between BA-7-ACA and the C-2 on indole ring of Trp-β4 residue of CA130.Here we reported that BA-7-ACA labeled CA130 (BA-C130) could self-catalyze the hydrolysis of BA-7-ACA during crystallization process. The hydrolysis was confirmed to be a reaction analogous to the one of GL-7-ACA by comparative MALDI-TOF (matrix-assisted laser desorption/ionization-time of flight) spectrometry analysis.

二、GL-7-AcA酰化酶CA130标记复合物的结晶过程研究溴乙酰氨基头孢烷酸(7β-bromoacetyl amino cephalosporanic acid,BA-7-ACA)作为戊二酰-7-氨基头孢烷酸(GL-7-ACA)的类似物,不仅能够抑制GL-7-ACA酰化酶CA130的活力,而且能通过在BA-7-ACA和CA130的β亚基第四位色氨酸吲哚环二位碳原子之间形成碳-碳共价键而将CA130特异的烷基化。

The effects of above-mentionedconditions on alkylene reaction are studied to obtain the optimum reactive conditionsby orthogonal experiments having seven factors and three levels. GCLE is chosen as material to prepare 7-phenyl acetamideyl vinyl cephalkyl acidp-methoxy benyl eatsr in the experiment. The process is as follow: GCLE reacts withiodide in solvent, and produce 3-iodid, then reacts with PPh_3 to produce Witting agent,and reacts with HCHO to produce 7-phenyl acetamideyl vinyl cephalkyl acid p-methoxy benyl eatsr in alkaline conditions.

试验选用GCLE作为原料制备7-苯乙酰氨基-3-乙烯基头孢烷酸对甲氧苄酯,反应过程如下:GCLE与碘化物、PPh3在溶剂中反应生成3位膦盐,在碱性条件下生成Wittig试剂再与HCHO反应生成7-苯乙酰氨基-3-乙烯基头孢烷酸对甲氧苄酯。

The content of amidogen monomer is a major factor affecting the product's amonia standard, but the viscosity is affected by direct ratio of the three factors.

氨基硅油产品的氨值指标而言,在聚合达到平衡时,原料中氨基单体的含量是其主要影响因素;对黏度而言,则受3种因素共同影响,并且与3种因素近似呈正比关系。

Moreover, it was successfully linked with lactobionic acid through amine groups on the surface of particles, and used to recognize living liver cells successfully.(3) In order to simplify the proceeding of preparation of silica-coated qdots, a novel one-pot method using 3-mercaptopropyl-trimethoxysilane as a capping molecule was proposed for the first time. Furthermore, amine and phosphonate groups were also modified on the surface of silica-coated qdots simultaneously. This was the first time the synthesis and the surface modification of qdots were performed in the same system.

3在前一部分工作的基础上,进一步简化量子点的合成与包壳步骤,以MPS为稳定剂,制备了硅壳包被的CdTe量子点,并在硅壳外同步修饰氨基及磷酸基团,首次成功实现了量子点的合成与表面的功能化修饰在同一体系中进行,从而制得了水溶性的、表面带有氨基和磷酸基团的硅壳型CdTe量子点。

And containing aminopyrine aminopyrine drugs.

氨基比林及含氨基比林的药物。

The transfer behavior of pyrazolone derivatives, such as antipyrine, aminopyrine, 4-aminoantipyrine and analgin, across the W/NB interface was investigated. The three medicines studied can form complex with a proton and the complex formed can transfer reversely across the W/NB interface and the transfer process was controlled by diffusion. The transfer of protonated analgin was not observed within potential window because of its high transfer potential.

研究了吡唑啉酮类的安替比林、氨基比林、4-氨基安替比林和安乃近四种药物在W/NB界面的转移行为,前三种药物在一定pH值的水溶液中结合一个质子形成1∶1质子配合物,并能在W/NB界面发生可逆转移,其转移过程受扩散控制,安乃近的质子化物由于有较高的转移电位而未在电位窗内观察到其转移峰。

Synthesis of N-substituted carbametes catalyzed by ionic liquids Ionic liquids were introduced into the syntheses of N-substituted carbamates from alkyl carbamates and amines.

离子液体为催化剂合成N-取代氨基甲酸酯将离子液体引入到小分子氨基甲酸烷基酯和有机胺合成N-取代氨基甲酸酯反应。

The degradation properties of sulfide flotation collectors such as Xanthogenate, Dithiocarbamate, Dithiophophate, N,N-dialkyl-dithiocarbamatecyanoethylene and Thionocarbamate are studied in this paper.

论文研究了黄原酸盐、氨基二硫代甲酸盐、二硫代磷酸盐、氨基二硫代丙烯腈酯、氨基硫逐甲酸酯等硫化矿捕收剂的降解性能。

Amino resin or amino paint is mixed with a certain amount of polyisocyanate and xylene solvent etc is added.

氨基树脂或氨基漆与一定比例的多异氰酸酯固化剂混合,加入二甲苯等稀释剂不浑浊,用氨基漆与合适比例的多异氰酸酯固化剂可配成综合性能优异的双组分聚氨酯

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