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The results indicate that the type and number of the substituents affect the toxicity of these compounds directly. A nitro group substitution increases the toxicity of the compounds, and on the contrary, an amido group substitution decreases their toxicity. For multi-nitrobenzenes, the toxicity of the o - or p -substituted nitrobenzene is bigger than that of the m -substituted one.

苯环上取代基的类型、数目和取代位置直接影响到标题化合物的毒性大小,强吸电子基如硝基会降低 Q -NO2和 E LUMO大小,使化合物毒性增强,且邻对位硝基取代的毒性高于间位取代;相反,给电子基团氨基的存在则会使化合物的毒性降低。

We described that the nitro group is a stronger electron withdrawing and meta activating characters than the imide group, the amino and hydroxy are both electron donating groups and had ortho, para activating characters. The methyl group might have a steric hindrance effect in this reaction. Our results indicated that methyl group at the ortho position of the amino group on the benzene ring, the steric hindrance effect became stronger.

另一方面,由产率上的结果来看,可以得知硝基为强力的拉电子基团,会减少邻位和对位胺基的电子密度比间位多;而氢氧基与胺基是供电子基团,会增加邻位和对位胺基的电子密度比间位多;甲基取代对反应则只有立体障碍的影响,而且与反应的氨基成邻位存在下影响最大。

Nitrations of both hydroxyl- and acetamino-substituted porphyrins were found to take place at the adjacent position of the substituent in the very aryl ring, whereas nitro group was guided into para positions of unsubstituted phenyl ring during the nitration of nitro-substituted porphyrin.

结果表明,羟基和乙酰氨基卟啉的硝化反应发生在与该取代基处于同一芳环的meta位,而硝基卟啉进行硝化时,硝基取代于其他未取代苯环的para位。

The method for producing 4-aminodiphenylamine from nitrobenzene and aniline was an ideal method at the present.

从硝基苯和苯胺直接合成4氨基二苯胺是当前一种较为理想的方法。

In the reaction of NAE18 with nitrogen mustard aryl phosphorochloridate, 4-dimethylaminopyridine played critical catalytic action.

在合成工作中发现:在NAE18与氮芥芳基磷酰氯的反应过程中, 4-二甲氨基吡啶起着关键性的催化作用。

Cytotoxic effect was demonstrated with nitrogen mustard, nitromin, sarcolysin, thio-TEPA and myleran at concentrations of 7, 10, 25, 35, 100, and 100μg/ml respectively.

氮芥及氧化氮芥在7—10微克/毫升,溶肉瘤素和新恩必恨于25—35微克/毫升,三乙酰硫代磷酰胺和丁二醇二甲磺酸酯在100微克/毫升,都出現了显著的細胞毒作用,使細胞很快死亡溶解;但6-巯基嘌吟和氨基喋吟未表現作用。

Using extracellular recording and microiontophoretic techniques, combined with whole-field visual stimulation, we studied the effects ofγ- aminobutyric acid and its antagonists bicuculline and 2- hydroxysaclofen on neuronal firings in nBOR and nLM in pigeons.

采用细胞外记录和微量离子电泳技术,结合全屏幕视觉刺激,研究了γ-氨基丁酸及其受体拮抗剂荷苞牡丹碱和2-hydroxysaclofen对家鸽基底视束核和扁豆核神经元的作用。

In the nonpolar solvent n-hexane, the ICT dual fluorescence of p-dialkylaminobenzoic acid was observed.

在非极性溶剂正己烷中,观测到了对二烷基氨基苯甲酸的ICT双重荧光。

Gamma-aminobutyric acid, a four-carbon nonprotein amino acid, serves as a major inhibitory neurotransmitter in mammalian nervous systems. GABA has several physiological functions such as hypotensive activity, treatment of epilepsy, tranquilizing and allaying excitement, enhancing memory, controlling asthma, regulating hormone secretion, promoting reproduction and activating liver and kidney function.

氨基丁酸(γ-aminobutyric acid,简称为GABA)是一种天然存在的非蛋白质氨基酸,为哺乳动物中枢神经系统中重要的抑制性神经递质,具有降血压、治疗癫痫、镇静安神、增强记忆、控制哮喘、调节激素分泌、促进生殖、活化肝肾等多种生理功能,其制备和应用广受人们的关注与重视。

The new water-soluble reagent N―Nonyl―N'―Sodium p-Aminobenzenesulfonate Thiourea NPT was synthesized and its structure was confirmed by elemental analysis,IR, UV and1 HNMR spectra.

合成了水溶性的新试剂N―壬基―N'―氨基对苯磺酸钠硫脲NPT,经元素分析、IR、UV、1HNMR测试,确定了其结构。

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